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Contrast-enhanced 3D MRI of lung perfusion in children with cystic fibrosis—initial results

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Abstract

This paper is a feasibility study of magnetic resonance imaging (MRI) of lung perfusion in children with cystic fibrosis (CF) using contrast-enhanced 3D MRI. Correlation assessment of perfusion changes with structural abnormalities. Eleven CF patients (9 f, 2 m; median age 16 years) were examined at 1.5 T. Morphology: HASTE coronal, transversal (TR/TE/α/ST: 600 ms/28 ms/180°/6 mm), breath-hold 18 s. Perfusion: Time-resolved 3D GRE pulse sequence (FLASH, TE/TR/α: 0.8/1.9 ms/40°), parallel imaging (GRAPPA, PAT 2). Twenty-five data sets were acquired after intravenous injection of 0.1 mmol/kg body weight of gadodiamide, 3–5 ml/s. A total of 198 lung segments were analyzed by two radiologists in consensus and scored for morphological and perfusion changes. Statistical analysis was performed by Mantel-Haenszel chi-square test. Results showed that perfusion defects were observed in all patients and present in 80% of upper, and 39% of lower lobes. Normal lung parenchyma showed homogeneous perfusion (86%, P<0.0001). Severe morphological changes led to perfusion defects (97%, P<0.0001). Segments with moderate morphological changes showed normal (53%) or impaired perfusion (47%). In conclusion, pulmonary perfusion is easy to judge in segments with normal parenchyma or severe changes. In moderately damaged segments, MRI of lung perfusion may help to better assess actual functional impairment. Contrast-enhanced 3D MRI of lung perfusion has the potential for early vascular functional assessment and therapy control in CF patients.

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Acknowledgement

This study was supported by Forschungsgemeinschaft Mukoviszidose (Mukoviszidose e.V.): S06/04.

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Authors and Affiliations

  1. Department of Radiology (E010), Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Monika Eichinger, Michael Puderbach, Sebastian Ley, Ivan Zuna & Hans-Ulrich Kauczor

  2. Department of Radiology, Institut für Klinische Radiologie, Klinikum der LMU Großhadern, Marchioninistr. 15, 81377, München, Germany

    Christian Fink

  3. Department of Pediatric Pulmonology, Cystic Fibrosis Centre and Infectious Diseases, Universitätskinderklinik III Heidelberg, Im Neuenheimer Feld 153, 69120, Heidelberg, Germany

    Julie Gahr & Frank-Michael Müller

  4. Department of Pediatric Radiology, Universitätskinderklinik Heidelberg, Im Neuenheimer Feld 153, 69120, Heidelberg, Germany

    Sebastian Ley

  5. Department of Diagnostic Radiology, Eberhard-Karls University, Hoppe-Syler 3, 72076, Tuebingen, Germany

    Christian Plathow

  6. Department of Radiology, Thoraxklinik am Universitätsklinikum Heidelberg, Amalienstr. 5, 69126, Heidelberg, Germany

    Siegfried Tuengerthal

Authors
  1. Monika Eichinger
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  2. Michael Puderbach
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  3. Christian Fink
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  4. Julie Gahr
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  5. Sebastian Ley
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  6. Christian Plathow
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  7. Siegfried Tuengerthal
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  8. Ivan Zuna
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  9. Frank-Michael Müller
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  10. Hans-Ulrich Kauczor
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Corresponding author

Correspondence to Monika Eichinger.

Additional information

Monika Eichinger and Michael Puderbach contributed equally to this work.

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Eichinger, M., Puderbach, M., Fink, C. et al. Contrast-enhanced 3D MRI of lung perfusion in children with cystic fibrosis—initial results. Eur Radiol 16, 2147–2152 (2006). https://doi.org/10.1007/s00330-006-0257-7

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  • DOI: https://doi.org/10.1007/s00330-006-0257-7

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