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Quantification of [123I]PE2I binding to dopamine transporters with SPET

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract.

The iodinated cocaine derivative [123I]PE2I is a new selective ligand for in vivo studies of the dopamine transporter (DAT) with single-photon emission tomography (SPET). The aim of the present study was to describe a method for accurate quantification of binding data following a bolus injection of [123I]PE2I. Six healthy subjects (age 51±24 years) underwent xenon-133 SPET for quantification of regional CBF and [123I]PE2I SPET for quantification of DAT binding. rCBFs were within normal limits in all subjects. Fitting data to a two-tissue compartment model resulted in striatal K1 values of 0.39±0.08 ml ml–1 min–1, equal to a first-pass extraction fraction of 0.72±0.13. Distribution volumes (DVs) were calculated using compartment analysis, area under the curve analysis and Logan analysis. Logan analysis is preferred since stable DV values were already obtained 120 min after [123I]PE2I injection. Mean striatal DV was 37.9±9.6 ml ml–1 and mean occipital cortex DV was 5.5±0.7 ml ml–1. In the absence of local pathology in a reference tissue, Logan analysis without blood sampling is an attractive method for accurate quantification of striatal [123I]PE2I binding. The distribution volume ratio (DVR) (6.6±1.4) was in good agreement with the DVR calculated with blood (6.7±1.4).

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Received 8 July and in revised form 2 December 2001

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Pinborg, L.H., Videbæk, C., Svarer, C. et al. Quantification of [123I]PE2I binding to dopamine transporters with SPET. Eur J Nucl Med 29, 623–631 (2002). https://doi.org/10.1007/s00259-001-0742-9

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  • DOI: https://doi.org/10.1007/s00259-001-0742-9

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