Abstract.
Apoptosis is likely to be the main form of beta-cell death in immune-mediated diabetes mellitus in rodents and possibly in humans. Clarification of the regulation of beta-cell death could indicate novel sites for therapeutic intervention in Type I (insulin-dependent) diabetes mellitus. We review the molecular effectors and signal transduction of immune-mediated beta-cell apoptosis.
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Received: 18 June 2001 and in revised form: 6 August 2001
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Eizirik, D., Mandrup-Poulsen, T. A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 44, 2115–2133 (2001). https://doi.org/10.1007/s001250100021
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DOI: https://doi.org/10.1007/s001250100021