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New insights into tumor-host interactions in lymphoma metastasis

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Abstract

The metastatic process is characterized by a complex series of sequential steps involving constant interactions (mutual “cross-talks”) of metastasized tumor cells with their microenvironment (lymphocyte, macrophages, endothelial cells, etc.) in target organs. These interactions determine the outcome of metastasis (either the eradication of metastatic cells or their increased proliferation and invasion). Recently developed methods of tumor and host cell analysis at the molecular level allow better elucidation of molecular mechanisms of metastasis and of immune mechanisms involved in antitumor responses. Direct modulation of these processes will probably increase the success of clinical cancer treatment. Here we review data (a) on the expression of some costimulatory (MHC class II, CD80, sialoadhesin) and adhesion (LFA1, ICAM-1, VLA-4) molecules on both metastasized tumor cells and host cells and (b) on the production of a cytotoxic molecule, nitric oxide, by in situ activated Kupffer and endothelial cells in the process of liver metastasis. This study was performed with well-characterized murine ESbL T lymphoma cells transduced with the bacterial lacZ gene, which allows detection and quantification of metastases at the single cell level throughout lymphoma growth and metastasis. Experimental results are discussed in the context of recent literature.

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Abbreviations

APC :

Antigen-presenting cells

hCRP :

Human C-reactive protein

ICAM :

Intercellular adhesion molecule

IFN :

Interferon

IL :

Interleukin

iNOS :

Inducible NO synthase

LFA :

Leukocyte function associated antigen

SER :

Sheep erythrocyte receptor

TA :

Tumor-associated rejection antigens

TNF :

Tumor necrosis factor

VCAM :

Vascular cell adhesion molecule

VLA :

Very late activated antigen

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  1. Tumor Immunology Program, Division of Cellular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany

    V. Umansky, V. Schirrmacher & M. Rocha

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  1. V. Umansky
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Umansky, V., Schirrmacher, V. & Rocha, M. New insights into tumor-host interactions in lymphoma metastasis. J Mol Med 74, 353–363 (1996). https://doi.org/10.1007/BF00210630

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  • DOI: https://doi.org/10.1007/BF00210630

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