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Acute myocardial infarction enhances the portal venous histamine level in dogs

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Objective and Design: The aim of our experiments was to determine the plasma histamine level in the portal venous (VP) blood during acute coronary occlusion and reperfusion.¶Subjects: 27 adult mongrel dogs of either sex were randomized for three groups: sham-operated controls, occlusion group (group O) and reperfusion group (group R).¶Treatment: The left circumflex coronary artery (LCx) was proximally occluded and the occlusion was maintained during 6 h (group O), or after a 60-min occlusion the LCx was reperfused (group R). The portal vein was cannulated to take blood samples for hormone measurements.¶Methods: The plasma histamine concentrations were measured with the radioenzymatic method.¶Results: The VP plasma histamine level was significantly increased 60 min after the LCx occlusion in groups O (99.9 ± 40.2 vs. 252.9 ± 100 pg/ml, mean ± SD) and R (101.2 ± 55.1 vs. 179.8 ± 96 pg/ml), and remained high in group O (240.4 ± 81 pg/ml), while 2 h after LCx reperfusion it had decreased to the basic level. There was no correlation between the hemodynamic parameters and the portal vein plasma histamine levels.¶Conclusions: Histamine is released into the gastrointestinal tract during acute myocardial ischemia and reperfusion, but the release of the vasoactive drug has no effect on systemic hemodynamics.

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Received 1 October 1996; returned for revision 17 December 1996; accepted by W. Lorenz 17 April 1997

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Gyöngyösi, M., Kaszaki, J., Wolfárd, A. et al. Acute myocardial infarction enhances the portal venous histamine level in dogs. Inflamm. res. 46, 253–259 (1997). https://doi.org/10.1007/s000110050183

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  • DOI: https://doi.org/10.1007/s000110050183

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