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Peptide toxins and potassium channels

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References

  • Abia A, Lobaton CD, Moreno A, Garcia-Sancho J (1986) Leiurus quinquestriatus venom inhibits different kinds of Ca2+-dependent K+ channels. Biochim Biophys Acta 856:403–407

    Google Scholar 

  • Alger BE, Williamson A (1988) A transient calcium-dependent potassium component of the epileptiform burst after-hyperpolarization in rat hippocampus. J Physiol (Lond) 399:191–205

    Google Scholar 

  • Anderson AJ (1985) The effects of protease inhibitor homologues from mamba snake venoms on autonomic neurotransmission. Toxicon 23:947–954

    Google Scholar 

  • Anderson AJ, Harvey AL (1988) Effects of the potassium channel blocking dendrotoxins on acetylcholine release and motor nerve terminal activity. Br J Pharmacol 93:215–221

    Google Scholar 

  • Anderson CS, MacKinnon R, Smith C, Miller C (1988) Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength. J Gen Physiol 91:317–333

    Google Scholar 

  • Banks BEC, Brown C, Burgess GM, Burnstock G, Claret M, Cocks TM, Jenkinson DH (1979) Apamin blocks certain neurotransmitter-induced increases in potassium permeability. Nature 282:415–417

    Google Scholar 

  • Barrett JC, Harvey AL (1979) Effects of the venom of the green mamba, Dendroaspis angusticeps on skeletal muscle and neuromuscular transmission. Br J Pharmacol 67:199–205

    Google Scholar 

  • Baumann A, Grupe A, Ackermann A, Pongs O (1988) Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous system. EMBO J 7:2457–2463

    Google Scholar 

  • Benishin CG, Sorensen RG, Brown WE, Krueger BK, Blaustein MP (1988) Four polypeptide components of green mamba venom selectively block certain potassium channels in rat brain synaptosomes. Mol Pharmacol 34:152–159

    Google Scholar 

  • Benoit E, Dubois J-M (1986) Toxin I from the snake Dendroaspis polylepis polylepis: a highly specific blocker of one type of potassium channel in myelinated nerve fiber. Brain Res 377:374–377

    Google Scholar 

  • Bidard J-N, Gandolfo G, Mourre C, Gottesmann C, Lazdunski M (1987a) The brain response to the bee venom peptide MCD. Activation and desensitization of a hippocampal target. Brain Res 418:235–244

    Google Scholar 

  • Bidard J-N, Mourre C, Lazdunski M (1987b) Two potent central convulsant peptides, a bee venom toxin, the MCD peptide, and a snake venom toxin, dendrotoxin I, known to block K+ channels, have interacting receptor sites. Biochem Biophys Res Commun 143:383–389

    Google Scholar 

  • Black AR, Dolly JO (1986) Two acceptor sub-types for dendrotoxin in chick synpatic membranes distinguishable by β-bungarotoxin. Eur J Biochem 156:609–617

    Google Scholar 

  • Black AR, Breeze AL, Othman IB, Dolly JO (1986) Involvement of neuronal acceptors for dendrotoxin in its convulsive action in rat brain. Biochem J 237:397–404

    Google Scholar 

  • Black AR, Donegan CM, Denny BJ, Dolly JO (1988) Solubilization and physical characterization of acceptors for dendrotoxin and β-bungarotoxin from synaptic membranes of rat brain. Biochemistry 27:6814–6820

    Google Scholar 

  • Blatz AL, Magleby KL (1986) Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle. Nature 323:718–720

    Google Scholar 

  • Bondy CA, Russel JT (1988) Dendrotoxin and 4-aminopyridine potentiate neurohypophysial hormone secretion during low frequency electrical stimulation. Brain Res 453:397–400

    Google Scholar 

  • Bourque CW (1988) Transient calcium-dependent potassium current in magnocellular neurosecretory cells of the rat supraoptic nucleus. J Physiol (Lond) 397:331–347

    Google Scholar 

  • Bourque CW, Brown DA (1987) Apamin and d-tubocurarine block the afterhyperpolarization of rat supraoptic neurosecretory neurons. Neurosci Lett 82:185–190

    Google Scholar 

  • Bräu ME, Dreyer F, Jonas P, Repp H, Vogel W (1990) A K+ channel in Xenopus nerve fibres selectively blocked by bee and snake toxins: binding and voltage-clamp experiments. J Physiol (Lond) 420:365–385

    Google Scholar 

  • Breithaupt H, Habermann E (1968) Mastzelldegranulierendes Peptid (MCD-Peptid) aus Bienengift: Isolierung, biochemische und pharmakologische Eigenschaften. Naunyn-Schmiedeberg's Arch Pharmacol 261:252–270

    Google Scholar 

  • Brown PD, Sepúlveda FV (1985) Potassium movements associated with amino acid and sugar transport in enterocytes from rabbit jejunum. J Physiol (Lond) 363:271–285

    Google Scholar 

  • Burgess GM, Claret M, Jenkinson DH (1981) Effects of quinine and apamin on the calcium-dependent potassium permeability of mammalian hepatocytes and red cells. J Physiol (Lond) 317:67–90

    Google Scholar 

  • Carbone E, Wanke E, Prestipino G, Possani LD, Maelicke A (1982) Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin. Nature 296:90–91

    Google Scholar 

  • Carbone E, Prestipino G, Spadavecchia L, Franciolini F, Possani LD (1987) Blocking of the squid axon K+ channel by noxiustoxin: a toxin from the venom of the scorpion Centruroides noxius. Pflügers Arch 408:423–431

    Google Scholar 

  • Castle NA, Strong PN (1986) Identification of two toxins from scorpion (Leiurus quinquestriatus) venom which block distinct classes of calcium-activated potassium channel. FEBS Lett 209:117–121

    Google Scholar 

  • Castle NA, Haylett DG, Jenkinson DH (1989) Toxins in the characterization of potassium channels. Trends Neurosci 12:59–65

    Google Scholar 

  • Chang CC (1979) The action of snake venoms on nerve and muscle. In: Lee CY (ed) Snake venoms, chap 10. Springer, Berlin Heidelberg New York, pp 309–376 (Handbook of experimental pharmacology, vol 52)

    Google Scholar 

  • Chang CC, Su MJ (1980) Mutual potentiation, at nerve terminals, between toxins from snake venoms which contain phospholipase A activity: β-bungarotoxin, crotoxin, taipoxin. Toxicon 18:641–648

    Google Scholar 

  • Cherubini E, Ben Ari Y, Gho M, Bidard JN, Lazdunski M (1987) Long-term potentiation of synaptic transmission in the hippocampus induced by a bee venom peptide. Nature 328:70–73

    Google Scholar 

  • Cherubini E, Neuman R, Rovira C, Ben Ari Y (1988) Epileptogenic properties of the mast cell degranulating peptide in CA3 hippocampal neurones. Brain Res 445:91–100

    Google Scholar 

  • Chesnut TJ, Carpenter DO, Strichartz GR (1987) Effects of venom from Conus striatus on the delayed rectifier potassium current of molluscan neurons. Toxicon 25:267–278

    Google Scholar 

  • Chicchi GG, Gimenez-Gallego G, Ber E, Garcia ML, Winquist R, Cascieri MA (1988) Purification and characterization of a unique, potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom. J Biol Chem 263:10 192–10 197

    Google Scholar 

  • Cognard C, Traoré F, Potreau D, Raymond G (1984) Effects of apamin on the outward potassium current of isolated frog skeletal muscle fibres. Pflügers Arch 402:222–224

    Google Scholar 

  • Cook NS (1988) The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol Sci 9:21–28

    Google Scholar 

  • Cook NS, Haylett DG (1985) Effects of apamin, quinine and neuromuscular blockers on calcium-activated potassium channels in guinea-pig hepatocytes. J Physiol (Lond) 358:373–394

    Google Scholar 

  • Cook NS, Haylett DG, Strong PN (1983) High affinity binding of [125I]monoiodoapamin to isolated guinea-pig hepatocytes. FEBS Lett 152:265–269

    Google Scholar 

  • Costa M, Furness JB, Humphreys CMS (1986) Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal tract. Naunyn-Schmiedeberg's Arch Pharmacol 332:79–88

    Google Scholar 

  • Cruz LJ, Gray WR, Yoshikami D, Olivera BM (1985) Conus venoms: a rich source of neuroactive peptides. J Toxicol-Toxin Rev 4:107–132

    Google Scholar 

  • Den Hertog A (1981) Calcium and the alpha-action of catecholamines on guinea-pig taenia caeci. J Physiol (Lond) 316:109–125

    Google Scholar 

  • Dolly JO, Halliwell JV, Black JD, Williams RS, Pelchen-Matthews A, Breeze AL, Mahraban F, Othman IB, Black AR (1984) Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release. J Physiol (Paris) 79:280–303

    Google Scholar 

  • Dreyer F, Penner R (1987) The actions of presynaptic snake toxins on membrane currents of mouse motor nerve terminals. J Physiol (Lond) 386:455–463

    Google Scholar 

  • Dubois J-M (1981) Evidence for the existence of three types of potassium channels in the frog Ranvier node membrane. J Physiol (Lond) 318:297–316

    Google Scholar 

  • Dubois JM (1982) Capsaicin blocks one class of K+ channels in the frog node of Ranvier. Brain Res. 245:372–375

    Google Scholar 

  • Dufton MJ (1985) Proteinase inhibitors and dendrotoxins. Sequence classification, structural prediction and structure/activity. Eur J Biochem 153:647–654

    Google Scholar 

  • Field A, Jenkinson DH (1987) The effect of noradrenaline on the ion permeability of isolated mammalian hepatocytes, studied by intracellular recording. J Physiol (Lond) 392:493–512

    Google Scholar 

  • Fosset M, Schmid-Antomarchi H, Hugues M, Romey G, Lazdunski M (1984) The presence in pig brain of an endogenous equivalent of apamin, the bee venom peptide that specifically blocks Ca2+-dependent K+ channels. Proc Natl Acad Sci USA 81:7228–7232

    Google Scholar 

  • Galvan M, Behrends J (1985) Apamin blocks calcium-dependent spike after-hyperpolarization in rat sympathetic neurones. Pflügers Arch 403:R50

    Google Scholar 

  • Gater PR, Haylett DG, Jenkinson DH (1985) Neuromuscular blocking agents inhibit receptor-mediated increases in the potassium permeability of intestinal smooth muscle. Br J Pharmacol 86:861–868

    Google Scholar 

  • Gimenez-Gallego G, Navia MA, Reuben JP, Katz GM, Kaczorowski GJ, Garcia ML (1988) Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels. Proc Natl Acad Sci USA 85:3329–3333

    Google Scholar 

  • Goedert M, Hunter JC, Ninkovic M (1984) Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum. Nature 311:59–62

    Google Scholar 

  • Goh JW, Pennefather PS (1987) Pharmacological and physiological properties of the after-hyperpolarization current of bullfrog ganglion neurones. J Physiol (Lond) 394:315–330

    Google Scholar 

  • Gray WR, Olivera BM, Cruz LJ (1988) Peptide toxins from venomous Conus snails. Ann Rev Biochem 57:665–700

    Google Scholar 

  • Guggino SE, Guggino WB, Green N, Sacktor B (1987) Blocking agents of Ca2+-activated K+ channels in cultured medullary thick ascending limb cells. Am J Physiol 252:C128–C137

    Google Scholar 

  • Habermann E (1968) Biochemie, Pharmakologie und Toxikologie der Inhaltsstoffe von Hymenopterengiften. Rev Physiol Biochem Exp Pharmacol 60:220–325

    Google Scholar 

  • Habermann E (1972) Bee and wasp venoms. Science 177:314–322

    Google Scholar 

  • Habermann E (1977) Neurotoxicity of apamin and MCD peptide upon central application. Naunyn-Schmiedeberg's Arch Pharmacol 300:189–191

    Google Scholar 

  • Habermann E (1984) Apamin. Pharmacol Ther 25:255–270

    Google Scholar 

  • Habermann E, Fischer K (1979) Bee venom neurotoxin (apamin): iodine labeling and characterization of binding sites. Eur J Biochem 94:355–364

    Google Scholar 

  • Habermann E, Horvath E (1980) Localization and effects of apamin after application to the central nervous system. Toxicon 18:549–560

    Google Scholar 

  • Habermann E, Reiz K-G (1965) Ein neues Verfahren zur Gewinnung der Komponenten von Bienengift, insbesondere des zentralwirksamen Peptids Apamin. Biochem Z 341:451–466

    Google Scholar 

  • Halliwell JV, Othman IB, Pelchen-Matthews A, Dolly JO (1986) Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors. Proc Natl Acad Sci USA 83:493–497

    Google Scholar 

  • Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85–100

    Google Scholar 

  • Harris JB (1985) Phospholipases in snake venoms and their effects on nerve and muscle. Pharmacol Ther 31:79–102

    Google Scholar 

  • Harvey AL, Anderson AJ (1985) Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. Pharmacol Ther 31:33–55

    Google Scholar 

  • Harvey AL, Gage PW (1981) Increase of evoked release of acetylcholine at the neuromuscular junction by a fraction from the venom of the eastern green mamba snake (Dendroaspis angusticeps). Toxicon 19:373–381

    Google Scholar 

  • Harvey AL, Karlsson E (1980) Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps. A neurotoxin that enhances acetylcholine release of neuromuscular junctions. Naunyn-Schmiedeberg's Arch Pharmacol 312:1–6

    Google Scholar 

  • Harvey AL, Karlsson E (1982) Protease inhibitor homologues from mamba venoms: facilitation of acetylcholine release and interactions with prejunctional blocking toxins. Br J Pharmacol 77:153–161

    Google Scholar 

  • Harvey AL, Anderson AJ, Karlsson E (1984a) Facilitation of transmitter release by neurotoxins from snake venoms. J Physiol (Paris) 79:222–227

    Google Scholar 

  • Harvey AL, Anderson AJ, Mbugua PM, Karlsson E (1984b) Toxins from mamba venoms that facilitate neuromuscular transmission. J Toxicol Toxin Rev 3:91–137

    Google Scholar 

  • Hermann A, Erxleben C (1987) Charybdotoxin selectively blocks small Ca-activated K channels in Aplysia neurons. J Gen Physiol 90:27–47

    Google Scholar 

  • Hermann A, Hartung K (1983) Ca2+ activated K+ conductance in molluscan neurones. Cell Calcium 4:387–405

    Google Scholar 

  • Hille B (ed) (1984) Ionic channels of excitable membranes. Sinauer, Sunderland MA

    Google Scholar 

  • Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (Lond) 117:500–544

    Google Scholar 

  • Hoshi T, Aldrich RW (1988) Voltage-dependent K+ currents and underlying single K+ channels in pheochromocytoma cells. J Gen Physiol 91:73–106

    Google Scholar 

  • Howard BD, Gundersen CB (1980) Effects and mechanisms of polypeptide neurotoxins that act presynaptically. Ann Rev Pharmacol Toxicol 20:307–336

    Google Scholar 

  • Hugues M, Duval D, Kitabgi P, Lazdunski M, Vincent JP (1982a) Preparation of a pure monoiodo derivative of the bee venom neurotoxin apamin and its binding properties to rat brain synaptosomes. J. Biol Chem 257:2762–2769

    Google Scholar 

  • Hugues M, Duval D, Schmid H, Kitabgi P, Lazdunski M, Vincent JP (1982b) Specific binding and pharmacological interactions of apamin, the neurotoxin from bee venom, with guinea-pig colon. Life Sci 31:437–443

    Google Scholar 

  • Hugues M, Romey G, Duval D, Vincent JP, Lazdunski M (1982c) Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: Voltage-clamp and biochemical characterization of the toxin receptor. Proc Natl Acad Sci USA 79:1308–1312

    Google Scholar 

  • Hugues M, Schmid H, Lazdunski M (1982d) Identification of a protein component of the Ca2+-dependent K+ channel by affinity labelling with apamin. Biochem Biophys Res Commun 107:1577–1582

    Google Scholar 

  • Hugues M, Schmid H, Romey G, Duval D, Frelin C, Lazdunski M (1982e) The Ca2+-dependent slow K+ conductance in cultured rat muscle cells: characterization with apamin. EMBO J 1:1039–1042

    Google Scholar 

  • Janicki PK, Horvath E, Seibold G, Habermann E (1984) Quantitative autoradiography of [125I]apamin binding sites in the central nervous system. Biomed Biochim Acta 43:1371–1375

    Google Scholar 

  • Jenkinson DH, Haylett DG, Cook NS (1983) Calcium-activated potassium channels in liver cells. Cell Calcium 4:429–437

    Google Scholar 

  • Jonas P, Bräu ME, Hermsteiner M, Vogel W (1989) Single-channel recording in myelinated nerve fibres reveals one type of Na channel but different K channels. Proc Natl Acad Sci USA 86:17238–17243

    Google Scholar 

  • Joubert FJ, Taljaard N (1980) The amino acid sequences of two proteinase inhibitor homologues from Dendroaspis angusticeps venom. Hoppe-Seylers Z Physiol Chem 361:661–674

    Google Scholar 

  • Karlsson E (1979) Chemistry of protein toxins in snake venoms. In: Lee CA (ed) Snake venoms, chap 5. Springer, Berlin Heidelberg New York, pp 159–212 (Handbook of experimental pharmacology, vol 52)

    Google Scholar 

  • Kawai T, Watanabe M (1986) Blockade of Ca-activated K conductance by apamin in rat sympathetic neurones. Br J Pharmacol 87:225–232

    Google Scholar 

  • Kitabgi P, Vincent J-P (1981) Neurotensin is a potent inhibitor of guinea-pig colon contractile activity. Eur J Pharmacol 74:311–318

    Google Scholar 

  • Koppenhöfer E, Schmidt H (1968) Die Wirkung von Skorpiongift auf die Ionenströme des Ranvierschen Schnürrings. I. Die Permeabilitäten PNa und PK. Pflügers Arch 303:133–149

    Google Scholar 

  • Lancaster B, Nicoll RA (1987) Properties of two calcium-activated hyperpolarizations in rat hippocampal neurones. J Physiol (Lond) 389:187–203

    Google Scholar 

  • Lebrun P, Atwater I, Claret M, Malaisse WJ, Herchuelz A (1983) Resistance to apamin of the Ca2+-activated K+ permeability in pancreatic B-cells. FEBS Lett 161:40–44

    Google Scholar 

  • Lewis RS, Cahalan MD (1988) Subset-specific expression of potassium channels in developing murine T lymphocytes. Science 239:771–775

    Google Scholar 

  • Maas AJJ, Den Hertog A (1979) The effect of apamin on the smooth muscle cells of the guinea-pig taenia coli. Eur J Pharmacol 58:151–156

    Google Scholar 

  • Maas AJJ, Den Hertog A, Ras R, Van den Akker J (1980) The action of apamin on guinea-pig taenia caeci. Eur J Pharmacol 67:265–274

    Google Scholar 

  • MacKinnon R, Miller C (1988) Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel. J Gen Physiol 91:335–349

    Google Scholar 

  • MacKinnon R, Reinhart PH, White MM (1988) Charybdotoxin block of Saker K+ channels suggests that different types of K+ channels share common structural features. Neuron 1:997–1001

    Google Scholar 

  • Mallart A (1985) Electric current flow inside perineural sheaths of mouse motor nerves. J Physiol (Lond) 368:565–575

    Google Scholar 

  • Marqueze B, Seagar M, Couraud F (1987) Photoaffinity labeling of the K+ channel-associated apamin-binding molecule in smooth muscle, liver and heart membranes. Eur J Biochem 169:295–298

    Google Scholar 

  • Mehraban F, Breeze AL, Dolly JO (1984) Identification by cross-linking of a neuronal acceptor protein for dendrotoxin, a convulsant polypeptide. FEBS Lett 174:116–122

    Google Scholar 

  • Mehraban F, Black AR, Breeze AL, Green DG, Dolly JO (1985) A functional membranous acceptor for dendrotoxin in rat brain: solubilization of the binding component. Biochem Soc Trans 13:507–508

    Google Scholar 

  • Miller C (1988) Competition for block of a Ca2+-activated K+ channel by charybdotoxin and tetraethylammonium. Neuron 1:1003–1006

    Google Scholar 

  • Miller C, Moczydlowski E, Latorre R, Philipps M (1985) Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature 313:316–318

    Google Scholar 

  • Moczydlowski E, Lucchesi K, Ravindran A (1988) An emerging pharmacology of peptide toxins targeted against potassium channels. J Membrane Biol 105:95–111

    Google Scholar 

  • Mourre C, Schmid-Antomarchi H, Hugues M, Lazdunski M (1984) Autoradiographic localization of apamin-sensitive Ca2+-dependent K+ channels in rat brain. Eur J Pharmacol 100:135–136

    Google Scholar 

  • Mourre C, Hugues M, Lazdunski M (1986) Quantitative autoradiographic mapping in rat brain of the receptor of apamin, a polypeptide toxin specific for one class of Ca2+-dependent K+ channels. Brain Res 382:239–249

    Google Scholar 

  • Mourre C, Cervera P, Lazdunski M (1987) Autoradiographic analysis in rat brain of the postnatal ontogeny of voltage-dependent Na+ channels, Ca2+-dependent K+ channels and slow Ca2+ channels identified as receptors for tetrodotoxin, apamin and (−)desmethoxyverapamil. Brain Res 417:21–32

    Google Scholar 

  • Mourre C, Bidard J-N, Lazdunski M (1988) High affinity receptors for the bee venom MCD peptide. Quantitative autoradiographic localization at different stages of brain development and relationship with MCD neurotoxicity. Brain Res 446:106–112

    Google Scholar 

  • Nanberg E, Connolly E, Nedergaard J (1985) Presence of Ca2+-dependent K+ channel in brown adipocytes. Possible role in maintenance of α1-adrenergic stimulation. Biochim Biophys Acta 844:42–49

    Google Scholar 

  • Naraghashi T, Shapiro BI, Deguchi T, Scuka M, Wang CM (1972) Effects of scorpion venom on squid axon membranes. Am J Physiol 222:850–857

    Google Scholar 

  • Oberg SG, Kelly RB (1976) Saturable binding to cell membranes of the presynaptic neurotoxin, β-bungarotoxin. Biochim Biophys Acta 433:662–673

    Google Scholar 

  • Olivera BM, Gray WR, Zeikus R, McIntosh JM, Varga J, Rivier J, de Santos V, Cruz LJ (1985) Peptide neurotoxins from fish-hunting cone snails. Science 230:1338–1343

    Google Scholar 

  • Othman IB, Spokes JW, Dolly JO (1982) Preparation of neurotoxic [3H]-β-bungarotoxin: demonstration of saturable binding to brain synapses and its inhibition by toxin I. Eur J Biochem 128:267–276

    Google Scholar 

  • Othman IB, Wilkin GP, Dolly JO (1983) Synaptic binding sites in brain for 3H-β-bungarotoxin — a specific probe that perturbs transmitter release. Neurochem Int 5:487–496

    Google Scholar 

  • Pappone PA, Cahalan MD (1987) Pandinus imperator scorpion venom blocks voltage-gated potassium channels in nerve fibers. J Neurosci 7:3300–3305

    Google Scholar 

  • Pappone PA, Lucero MT (1988) Pandinus imperator scorpion venom blocks voltage-gated potassium channels in GH3 cells. J Gen Physiol 91:817–833

    Google Scholar 

  • Pelchen-Matthews A, Dolly JO (1988) Distribution of acceptors for β-bungarotoxin in the central nervous system of the rat. Brain Res 441:127–138

    Google Scholar 

  • Pennefather P, Lancaster B, Adams PR, Nicoll RA (1985) Two distinct Ca-dependent K currents in bullfrog sympathetic ganglion cells. Proc Natl Acad Sci USA 82:3040–3044

    Google Scholar 

  • Penner R, Dreyer F (1986) Two different presynaptic calcium currents in mouse motor nerve terminals. Pflügers Arch 406:190–197

    Google Scholar 

  • Penner R, Petersen M, Pierau Fr-K, Dreyer F (1986) Dendrotoxin: a selective blocker of a non-inactivating potassium current in guinea-pig dorsal root ganglion neurones. Pflügers Arch 407:365–369

    Google Scholar 

  • Petersen M, Penner R, Pierau Fr-K, Dreyer F (1986) β-Bungarotoxin inhibits a non-inactivating potassium current in guinea pig dorsal root ganglion neurones. Neurosci Lett 68:141–145

    Google Scholar 

  • Possani LD, Martin BM, Svendsen IB (1982) The primary structure of noxiustoxin: a K+ channel blocking peptide, purified from the venom of the scorpion Centruroides Noxius Hoffmann. Carlsberg Res Commun 47:285–289

    Google Scholar 

  • Rehm H, Betz H (1982) Binding of β-bungarotoxin to synaptic membrane fractions of chick brain. J Biol Chem 257:10015–10022

    Google Scholar 

  • Rehm H, Betz H (1983) Identification by crosslinking of a β-bungarotoxin binding polypeptide in chick brain menbranes. EMBO J:1119–1122

    Google Scholar 

  • Rehm H, Betz H (1984) Solubilization and characterization of the β-bungarotoxin-binding protein of chick brain membranes. J Biol Chem 259:6865–6869

    Google Scholar 

  • Rehm H, Lazdunski M (1988a) Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I. Proc Natl Acad Sci USA 85:4919–4923

    Google Scholar 

  • Rehm H, Lazdunski M (1988b) Existence of different populations of the dendrotoxin I binding protein associated with neuronal K+ channels. Biochem Biophys Res Commun 153:231–240

    Google Scholar 

  • Rehm H, Bidard J-N, Schweitz H, Lazdunski M (1988) The receptor site for the bee venom mast cell degranulating peptide. Affinity labeling and evidence for a common molecular target for mast cell degranulating peptide and dendrotoxin I, a snake toxin active on K+ channels. Biochemistry 27:1827–1832

    Google Scholar 

  • Renaud J-F, Desnuelle C, Schmid-Antomarchi H, Hugues M, Serratrice G, Lazdunski M (1986) Expression of apamin receptor in muscles of patients with myotonic muscular dystrophy. Nature 319:678–680

    Google Scholar 

  • Ritchie AK (1987) Two distinct calcium-activated potassium currents in a rat anterior pituitary cell line. J Physiol (Lond) 385:591–609

    Google Scholar 

  • Rogawski MA (1985) The A-current: how ubiquitous a feature of excitable cells is it? Trends Neurosci 83:214–219

    Google Scholar 

  • Romey G, Lazdunski M (1984) The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions. Biochem Biophys Res Commun 118:669–674

    Google Scholar 

  • Romey G, Chicheportiche R, Lazdunski M (1975) Scorpion neurotoxin, a presynaptic toxin which affects both Na+ and K+ channels in axons. Biochem Biophys Res Commun 64:115–121

    Google Scholar 

  • Romey G, Hugues M, Schmid-Antomarchi H, Lazdunski M (1984) Apamin: a specific toxin to study a class of Ca2+-dependent K+ channels. J Physiol (Paris) 79:259–264

    Google Scholar 

  • Rosario LM (1985) Differential effects of the K+ channel blockers apamin and quinine on glucose-induced electrical activity in pancreatic beta-cells from a strain of OB/OB (obese) mice. FEBS Lett 188:302–306

    Google Scholar 

  • Rowan EG, Harvey AL (1988) Potassium channel blocking actions of β-bungarotoxin and related toxins on mouse and frog motor nerve terminals. Br J Pharmacol 94:839–847

    Google Scholar 

  • Rudy B (1988) Diversity and ubiquity of K channels. Neuroscience 25:729–749

    Google Scholar 

  • Schauf CL (1987) Dendrotoxin blocks potassium channels and slows sodium inactivation in Myxicola giant axons. J Pharmacol Exp Ther 241:793–796

    Google Scholar 

  • Schmid-Antomarchi H, Hugues M, Norman R, Ellory C, Borsotto M, Lazdunski M (1984) Molecular properties of the apamin-binding component of the Ca2+-dependent K+ channel. Radiation-inactivation, affinity labelling and solubilization. Eur J Biochem 142:1–6

    Google Scholar 

  • Schmid-Antomarchi H, Renaud J-F, Romey G, Hugues M, Schmid A, Lazdunski M (1985) The all-or-none role of innervation in expression of apamin receptor and of apamin-sensitive Ca2+-activated K+ channel in mammalian skeletal muscle. Proc Natl Acad Sci USA 82:2188–2191

    Google Scholar 

  • Schmid-Antomarchi H, Hugues M, Lazdunski M (1986) Properties of the apamin-sensitive Ca2+-activated K+ channel in PC12 pheochromocytoma cells which hyperproduce the apamin receptor. J Biol Chem 261:8633–8637

    Google Scholar 

  • Schmidt RR, Betz H (1988) The β-bungarotoxin-binding protein from chick brain: binding sites for different neuronal K+ channel ligands co-fractionate upon partial purification. FEBS Lett 240:65–70

    Google Scholar 

  • Schmidt RR, Betz H, Rehm H (1988) Inhibition of β-bungarotoxin binding to brain membranes by mast cell degranulating peptide, toxin I and ethylene glycol bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid. Biochemistry 27:963–967

    Google Scholar 

  • Schweitz H, Stansfeld CE, Bidard J-N, Fagni L, Maes P, Lazdunski M (1989) Charybdotoxin blocks dendrotoxin-sensitive voltage-activated K+ channels. FEBS Lett 250:519–522

    Google Scholar 

  • Seagar MJ, Granier C, Couraud F (1984) Interactions of the neurotoxin apamin with a Ca2+-activated K+ channel in primary neuronal cultures. J Biol Chem 259:1491–1495

    Google Scholar 

  • Seagar MJ, Labbé-Jullié C, Granier C, van Rietschoten J, Couraud F (1985) Photoaffinity labeling of components of the apamin-sensitive K+ channel in neuronal membranes. J Biol Chem 260:3895–3898

    Google Scholar 

  • Seagar MJ, Labbé-Jullié C, Granier C, Goll A, Glossmann H, van Rietschoten J, Couraud F (1986) Molecular structure of rat brain apamin receptor: differential photoaffinity labelling of putative K+ channel subunits and target size analysis. Biochemistry 25:4051–4057

    Google Scholar 

  • Seagar MJ, Deprez P, Martin-Moutot N, Couraud F (1987a) Detection and photoaffinity labeling of the Ca2+-activated K+ channel-associated apamin receptor in cultured astrocytes from rat brain. Brain Res 411:226–230

    Google Scholar 

  • Seagar MJ, Marqueze B, Couraud F (1987b) Solubilization of the apamin receptor associated with a calcium-activated potassium channel from rat brain. J Neurosci 7:565–570

    Google Scholar 

  • Shuba MF, Vladimirova IA (1980) Effect of apamin on the electrical responses of smooth muscle to adenosine 5′-triphosphate and to non-adrenergic, non-cholinergic nerve stimulation. Neuroscience 5:853–859

    Google Scholar 

  • Silveira R, Barbeito L, Dajas F (1988) Behavioral and neurochemical effects of intraperitoneally injected dendrotoxin. Toxicon 26:287–292

    Google Scholar 

  • Sitges M, Possani LD, Bayon A (1986) Noxiustoxin, a shortchain toxin from the Mexican scorpion Centruroides noxius, induces transmitter release by blocking K+ permeability. J Neurosci 6:1570–1574

    Google Scholar 

  • Smith C, Phillips M, Miller C (1986) Purification of charybdotoxin, a specific inhibitor of the high-conductance Ca2+-activated K+ channel. J Biol Chem 261:14607–14613

    Google Scholar 

  • Solc CK, Zagotta WN, Aldrich RW (1987) Single-channel and genetic analysis reveal two distinct A-type potassium channels in Drosophila. Science 236:1094–1098

    Google Scholar 

  • Stanfield PR (1983) Tetraethylammonium ions and the potassium permeability of excitable cells. Rev Physiol Biochem Pharmacol 97:1–67

    Google Scholar 

  • Stansfeld CE, Feltz A (1988) Dendrotoxin-sensitive K+ channels in dorsal root ganglion cells. Neurosci Lett 93:49–55

    Google Scholar 

  • Stansfeld CE, Marsh SJ, Halliwell JV, Brown DA (1986) 4-Aminopyridine and dendrotoxin induce repetitive firing in rat visceral sensory neurones by blocking a slowly inactivating outward current. Neurosci Lett 64:299–304

    Google Scholar 

  • Stansfeld CE, Marsh SJ, Parcej DN, Dolly JO, Brown DA (1987) Mast cell degranulating peptide and dendrotoxin selectively inhibit a fast-activating potassium current and bind to common neuronal proteins. Neurosci 23:893–902

    Google Scholar 

  • Storm JF (1987) Action potential repolarization and a fast after-hyperpolarization in rat hippocampal pyramidal cells. J Physiol (Lond) 385:733–759

    Google Scholar 

  • Strydom DJ (1973) Protease inhibitors as snake venom toxins. Nature (New Biol) 243:88–89

    Google Scholar 

  • Stühmer W, Stocker M, Sakmann B, Seeburg P, Baumann A, Grupe A, Pongs O (1988) Potassium channels expressed from rat bain cDNA have delayed rectifier properties. FEBS Lett 242:199–206

    Google Scholar 

  • Szente MB, Baranyi A, Woody CD (1988) Intracellular injection of apamin reduces a slow potassium current mediating afterhyperpolarizations and IPSPs in neocortical neurons of cats. Brain Res 461:64–74

    Google Scholar 

  • Tabti N, Bourret C, Mallart A (1989) Three potassium currents in mouse motor nerve terminals. Pflügers Arch 413:395–400

    Google Scholar 

  • Tanaka K, Minota S, Kuba K, Koyano K, Abe T (1986) Differential effects of apamin on Ca2+-dependent K+ currents in bullfrog sympathetic ganglion cells. Neurosci Lett 69:233–238

    Google Scholar 

  • Tas PWL, Kress HG, Koschel K (1988) Presence of a charybodtoxin sensitive Ca2+-activated K+ channel in rat glioma C6 cells. Neurosci Lett 94:279–284

    Google Scholar 

  • Taylor JW, Bidard J-N, Lazdunski M (1984) The characterization of high-affinity binding sites in rat brain for the mast cell-degranulating peptide from the bee venom using the purified monoiodinated peptide. J Biol Chem 259:13957–13967

    Google Scholar 

  • Timpe LC, Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY (1988) Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes. Nature 331:143–145

    Google Scholar 

  • Traoré, Cognard C, Potreau D, Raymond G (1986) The apamin-sensitive potassium current in frog skeletal muscle: its dependence on the extracellular calcium and sensitivity to calcium channel blockers. Pflügers Arch 407:199–203

    Google Scholar 

  • Tzeng M-C, Hseu MJ, Yang JH, Guillory RJ (1986) Specific binding of three neurotoxins with phospholipase A2 activity to synaptosomal membrane preparations from the guinea pig brain. J Protein Chem 5:221–228

    Google Scholar 

  • Valdivia HH, Smith JS, Martin BM, Coronado R, Possani LD (1988) Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+(Ca2+) channel. FEBS Lett 226:280–284

    Google Scholar 

  • Velluti JC, Caputi A, Macadar O (1987) Limbic epilepsy induced in the rat by dendrotoxin, a polypeptide isolated from the green mamba (Dendroaspis angusticeps) venom. Toxicon 25:649–657

    Google Scholar 

  • Vladimirova AI, Shuba MF (1978) Effect of strychnine, hydrastine and apamin on synaptic transmission in smooth muscle cells. Neurophysiology 10:213–217

    Google Scholar 

  • Weir SW, Weston AH (1986) Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea-pig taenia caeci. Br J Pharmacol 88:113–120

    Google Scholar 

  • Weller U, Bernhardt U, Siemen D, Dreyer F, Vogel W, Habermann E (1985) Electrophysiological and neurobiochemical evidence for the blockade of a potassium channel by dendrotoxin. Naunyn-Schmiedeberg's Arch Pharmacol 330:77–83

    Google Scholar 

  • Wolff D, Cecchi X, Spalvins A, Canessa M (1988) Charybdotoxin blocks with high affinity the Ca-activated K+ channel of Hb A and Hb S red cells: individual differences in the number of channels. J Membrane Biol 106:243–252

    Google Scholar 

  • Wu K, Carlin R, Sachs L, Siekevitz P (1985) Existence of a Ca2+-dependent K+ channel in synaptic membrane and postsynaptic density fractions isolated from canine cerebral cortex and cerebellum, as determined by apamin binding. Brain Res 360:183–194

    Google Scholar 

  • Zhang L, Krnjevic K (1987) Apamin depresses selectively the after-hyperpolarization of cat spinal mononeurons. Neurosci Lett 74:58–62

    Google Scholar 

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  1. Rudolf-Buchheim-Institut für Pharmakologie, Justus-Liebig Universität, Frankfurter Str. 107, D-6300, Gießen, FRG

    Florian Dreyer

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© 1990 Springer-Verlag

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Dreyer, F. (1990). Peptide toxins and potassium channels. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 115. Reviews of Physiology, Biochemistry and Pharmacology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0033953

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