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Hyperpolarization-activated cation channels: A multi-gene family

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Book cover Reviews of Physiology, Biochemistry and Pharmacology, Volume 136

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 136))

Abstract

Since the first discovery of an Ih current in heart pacemaker cells about twenty years ago our knowledge on this ion channel class has increased substantially. Studies from a variety of groups have clearly demonstrated that Ih is not only required for cardiac pacemaking but also is a key regulator of several neuronal functions. The long-sought molecular cloning of the genes underlying Ih has now provided the basis to achieve a deeper understanding of the molecular function and physiological regulation of these channels. In addition, the powerful approaches of mouse genetics will enable us to study the physiological roles of the channels in significantly more detail than it was possible up to now.

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Authors and Affiliations

  1. Institut für Pharmakologie und Toxikologie der Technischen Universität München, Biedersteiner Straße 29, D-80802, München, Germany

    M. Biel, A. Ludwig, X. Zong & F. Hofmann

Authors
  1. M. Biel
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  2. A. Ludwig
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  3. X. Zong
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  4. F. Hofmann
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© 1999 Springer-Verlag

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Biel, M., Ludwig, A., Zong, X., Hofmann, F. (1999). Hyperpolarization-activated cation channels: A multi-gene family. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 136. Reviews of Physiology, Biochemistry and Pharmacology, vol 136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0032324

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  • DOI: https://doi.org/10.1007/BFb0032324

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65151-2

  • Online ISBN: 978-3-540-49542-0

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