Abstract
T acts as a vasodilator in vitro and in vivo. Supplemental T therapy in humans with angina improves symptoms and reduces objective measures of ischemia. In left anterior descending coronary arteries taken from adult male Wistar rats, T abolishes 100±4.2% of calcium-dependent contraction induced by potassium chloride, 82.3±6.1% of the mostly calcium-dependent contraction induced by prostaglandin-F-2-α, but only 45.3+_3.4% of the contraction induced by phorbol-12,13-dibutyrate (PDBu) in the presence of extracellular calcium, and 54.5±4.5% of the contraction induced by PDBu in the absence of extracellular calcium. These findings suggest that T is primarily inhibiting the calcium-dependent elements of vascular contraction.
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English, K.M., Jones, R.D., Jones, T.H. et al. Testosterone acts as a coronary vasodilator by a calcium antagonistic action. J Endocrinol Invest 25, 455–458 (2002). https://doi.org/10.1007/BF03344037
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DOI: https://doi.org/10.1007/BF03344037