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Diclofenac sodium and spasmolytic drugs in the treatment of ureteral colic: A comparative study

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Abstract

Forty-nine patients with ureteral colic were included in this prospective double-blind study investigating the analgesic efficacy and side effects of a prostaglandin synthetase inhibitor Diclofenac sodium (Voltaren®) versus a spasmolytic drug Tropenzilium bromide (Palerol®). The analgesic efficacy and side effects of the calcium antagonist Nifedipine (Nidilat®) applied sublingually in ureteral colic were also investigated.

It was concluded that diclofenac sodium was more efficient for relieving pain due to acute ureteral obstruction and had fewer side effects than spasmolytic drugs. Nifedipine proved to have an analgesic effect equivalent to that of Tropenziilium bromide.

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References

  1. Nishikawa, N., Morrison, A., Needleman, P.: Exaggerated prostaglandin biosynthesis and its influence on renal resistance in the isolated hydronephrotic rabbit kidney.J. Clin. Invest., 59, 1143 (1977).

    Article  PubMed  CAS  Google Scholar 

  2. Allen, J. T., Vaughan, E. D., Gillenwater, J. Y.: The effect of indomethacin on renal blood flow and ureteral pressure in unilateral ureteral obstruction in awake dogs.Invest. Urol., 15, 324 (1978).

    PubMed  CAS  Google Scholar 

  3. Al-Ugaily, L., Thulesius, O., Angelo-Khattar, M.: New evidence for prostaglandin induced motility of the ureter.Scand. J. Urol. Nephrol., 20, 225 (1986).

    PubMed  CAS  Google Scholar 

  4. Kantor, T. G.: Use of Diclofenac in analgesia.Am. J. Med., 80, 64 (1986).

    Article  PubMed  CAS  Google Scholar 

  5. Carol, W.: Nifedipine and ureteral colic.Ann. Int. Med., 102, 864 (1985).

    Google Scholar 

  6. Bortolotti, M., Trisolino, G., Barbara, L.: Nifedipine in biliary and renal colic.JAMA, 258, 3516 (1987).

    Article  PubMed  CAS  Google Scholar 

  7. Viskin, S., Kaver, I., Greenstein, A., Hassner, A.: Nifedipine and ureteral colic.Ann. Int. Med., 105, 142 (1986).

    PubMed  CAS  Google Scholar 

  8. Lundstam, S. O. A., Leissner, K. H., Waohlander, L. A., Kral, J. G.: Prostaglandin synthetase inhibition with Diclofenac sodium in treatment of renal colic: Comparison with use of a narcotic analgesic.Lancet, 1, 1096 (1982).

    Article  PubMed  CAS  Google Scholar 

  9. Hetherington, J. W.: Diclofenac sodium versus pethidine in acute renal colic.Br. Med. J., 292, 237 (1986).

    Article  CAS  Google Scholar 

  10. Khalifa, S. K., Sharkawi, M. A.: Treatment of pain owing to acute ureteral obstruction with prostaglandin synthetase inhibitor. A prospective randomised study.J. Urol., 136, 393 (1986).

    PubMed  CAS  Google Scholar 

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Başar, I., Bircan, K., Taşar, Ç. et al. Diclofenac sodium and spasmolytic drugs in the treatment of ureteral colic: A comparative study. International Urology and Nephrology 23, 227–230 (1991). https://doi.org/10.1007/BF02550416

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  • DOI: https://doi.org/10.1007/BF02550416

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