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Quantitative trait loci for ethanol sensitivity in the LS X SS recombinant inbred strains: Interval mapping

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Abstract

We are mapping the genes (quantitative trait loci or QTLs) that are responsible for individual differences in ethanol sensitivity, measured as the duration of loss of righting reflex (LORR) and blood ethanol concentrations upon recovery of the righting reflex (BEC). The Long-Sleep (LS) and Short-Sleep (SS) selected lines of mice manifest an 18-fold difference in LORR and serve as a rodent model for ethanol sensitivity. The LS x SS recombinant inbred (RI) series, developed from LS and SS lines, are an important resource for QTL mapping of ethanol-related responses. The current report summarizes the initial QTL analysis of LORR and BEC in the LS x SS strains and compares the results of correlational analysis with an interval-mapping approach. The data provide strong evidence for QTLs that influence ethanol sensitivity on mouse chromosomes 1 and 2 and possible QTLs on chromosomes 1, 3, 4, 5, 6, 7, 12, 13, 16, and 18. These results are compared to those from an F2 cross which confirms QTLs on chromsomes 1, 2, 4, and 18.

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Authors and Affiliations

  1. Institute for Behavioral Genetics, University of Colorado, Campus Box 447, 80309-0447, Boulder, Colorado

    Paul D. Markel, David W. Fulker, Beth Bennett, Robin P. Corley, John C. DeFries, V. Gene Erwin & Thomas E. Johnson

  2. Department of Psychology, University of Colorado, 80309, Boulder, Colorado

    Paul D. Markel, David W. Fulker, John C. DeFries & Thomas E. Johnson

  3. School of Pharmacy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box C238, 80262, Denver, Colorado

    Paul D. Markel & V. Gene Erwin

  4. Department of Veterans Affairs Alcohol Research Center, 80220, Denver, Colorado

    Beth Bennett & Thomas E. Johnson

Authors
  1. Paul D. Markel
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  2. David W. Fulker
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  3. Beth Bennett
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  4. Robin P. Corley
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  5. John C. DeFries
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  6. V. Gene Erwin
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  7. Thomas E. Johnson
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Correspondence to Paul D. Markel.

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Markel, P.D., Fulker, D.W., Bennett, B. et al. Quantitative trait loci for ethanol sensitivity in the LS X SS recombinant inbred strains: Interval mapping. Behav Genet 26, 447–458 (1996). https://doi.org/10.1007/BF02359489

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  • DOI: https://doi.org/10.1007/BF02359489

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