Summary
A convenient procedure for the extraction and determination of three organophosphate insecticides, their active oxygen analogs, and their inactive metabolites in biological tissues is described. The utility of this technique is demonstrated by measurement of thein vitro biotransformation of both parathion and chlorpyrifos by mouse hepatic microsomes.
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References
S. D. Murphy, in Toxicology, the Basic Science of Poisons. John Doull, Curtis Klassen, and Mary Amdur, eds. Macmillan Publishing Co. Inc., New York, 1980, second edition, pp. 357–408.
T. Abe, Y. Fujimoto, T. Tatsuro, J. Fukami, Bull. Environm. Contam. Toxicol.22, 791 (1979).
J. Sherma, G. Zweig, Anal. Chem.53, 77R (1981).
J. F. Lawrence, D. Turton, J. Chromatogr.159, 207 (1978).
M. T. Shafik, D. Bradway, H. F. Enos, J. Agr. Food Chem.19, 885 (1971).
P. F. Blanchet, J. Agric. Food Chem.27, 204 (1979).
N. E. Skelly, P. J. Jensen, P. K. Anderson, J. Ass. Off. Anal. Chem.64, 628 (1981).
E. M. Lores, D. E. Bradway, J. Agric. Food Chem.25, 75 (1977).
S. N. Lin, C. Y. Chen, S. D. Murphy, R. M. Caprioli, J. Agric. Food Chem.28, 85 (1980).
R. A. Neal, Biochem. J.103, 183 (1966).
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Sultatos, L.G., Costa, L.G. & Murphy, S.D. Determination of organophosphorus insecticides, their oxygen analogs and metabolites by high pressure liquid chromatography. Chromatographia 15, 669–671 (1982). https://doi.org/10.1007/BF02279499
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DOI: https://doi.org/10.1007/BF02279499