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Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes

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Abstract

The suggestions that dopamine (DA) systems are involved in “motor control” and “reward” represent the classic working hypotheses on the behavioral functions of these systems. The research generated by these hypotheses has yielded results that are far more complicated than the simplest form of either hypothesis would indicate. Pharmacological or lesion-induced interference with DA function does not suppress all aspects of movement control, nor all aspects of reward, nor all aspects of motivation. The deficits produced by interference with DA systems are selective and dissociative in nature, affecting some aspects of motor or motivational function, but leaving others basically intact. In some sense the hypotheses that DA is involved in “motor” or “reward” or “motivational” processes are partly correct, but the processes to which these terms refer are too broad to offer an accurate and detailed description of the behavioral functions of brain DA. A review of the literature on the behavioral pharmacology of DA suggests that the behaviors most easily disrupted by DA antagonists are highly activated and complex learned instrumental responses that are elicited or supported by mild conditioned stimuli, and maintained for considerable periods of time. It is proposed that DA in accumbens and striatum modulates the ability of neocortical and limbic areas involved in sensory, associative, and affective processes to influence complex aspects of motor function, and also modulates the execution of complex motor acts organized by the neocortex. Thus, interference with DA systems produces a “subcortical apraxia”, which dissociates complex stimulus processes from complex motor processes, but leaves aspects of those processes intact.

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References

  • Abercrombie EA, Jacobs BL (1985) Dopaminergic modulation of sensory responses of striatal neurons: single unit studies. Brain Res 358:27–33

    Article  PubMed  Google Scholar 

  • Abercrombie EA, Keefe KA, DiFrischia DA, Zigmond MJ (1989a) Differential effect of stress on in vivo dopamine release in striatum, nucleus accumbens and medial frontal cortex. J Neurochem 52:1655–1658

    PubMed  Google Scholar 

  • Abercrombie EA, Keefe KA, Zigmond MJ (1989b) Evidence that nerve terminal density is an important contributor to apparent differences in the activation of central dopamine systems. Behav Pharmacol 1 [suppl 1]:26

    Google Scholar 

  • Ahlenius S (1979) An analysis of behavioral effects produced by drug-induced changes in dopaminergic neurotransmission in the brain. Scand J Psychol 20:59–64

    Google Scholar 

  • Alexander GE, DeLong MR, Strick PL (1986) Parallel organizations of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357–381

    Article  PubMed  Google Scholar 

  • Anisman H, Zacharko R (1982) Stimulus change influences escape performance: Deficits induced by uncontrollable stress and by haloperidol. Pharmacol Biochem Behav 17:263–269

    Google Scholar 

  • Anisman H, Remington G, Sklar LS (1979) Effect of inescapable shock on subsequent escape performance: catecholaminergic and cholinergic mediation of response initiation and maintenance. Psychopharmacology 61:107–124

    Google Scholar 

  • Angel RW, Alston W, Higgins JR (1970) Control of movement in Parkinson's disease. Brain 93:1–14

    PubMed  Google Scholar 

  • Antleman SM, Rowland RE, Fisher AE (1976) Stress related recovery from lateral hypothalamic aphagia. Brain Res 102:346–350

    Article  PubMed  Google Scholar 

  • Asin KE, Fibiger HC (1984) Force requirements in lever-pressing and responding after haloperidol. Pharmacol Biochem Behav 20:323–326

    Google Scholar 

  • Baum WM, Rachlin HC (1969) Choice as time allocation. J Exp Anal Behav 12:861–874

    Google Scholar 

  • Beninger RJ (1982) A comparison of the effects of pimozide and nonreinforcement on discriminated operant responding in rats. Pharmacol Biochem Behav 16:667–669

    Google Scholar 

  • Beninger RJ (1983) The role of dopamine activity in locomotor activity and learning. Brain Res Rev 6:173–196

    Article  Google Scholar 

  • Beninger RJ (1991) Receptor subtype-specific dopamine agonists and antagonists and conditioned behavior. In: Willner P, Scheel-Kruger J (eds) The mesolimbic dopamine sytem: from motivation to action. Cambridge University Press, Cambridge, England, pp 273–300

    Google Scholar 

  • Beninger RJ, Phillips AG (1980) The effect of pimozide on the establishment of conditioned reinforcement. Psychopharmacology 68:147–153

    Google Scholar 

  • Beninger RJ, Maclennan AJ, Pinel JPJ (1980a) The use of conditioned defensive burying to test the effects of pimozide on associative learning. Pharmacol Biochem Behav 12:445–448

    Google Scholar 

  • Beninger BJ, Mason ST, Phillips AG, Fibiger HC (1980b) Use of conditioned suppression to evaluate the nature of neuroleptic-induced avoidance deficits. J Pharmacol Exp Ther 213:623–627

    PubMed  Google Scholar 

  • Berlyne DE (1967) Arousal and reinforcement. In: Levine D (ed) Nebraska Symposium on Motivation. University of Nebraska Press, Lincoln, Nebraska, pp 1–110

    Google Scholar 

  • Berridge KC, Venier IL, Robinson TE (1989) Taste reactivity analysis of 6-hydroxydopamine-induced aphagia: implications for arousal and anhedonia hypotheses of dopamine function. Behav Neurosci 103:36–45

    Article  PubMed  Google Scholar 

  • Bindra D (1972) Neuropsychological interpretation of the effects of drive and incentive-motivation on general and instrumental behavior. Psychol Rev 75:1–22

    Google Scholar 

  • Bindra D (1974) A motivational view of learning, performance and behavior modification. Psychol Rev 81:199–213

    PubMed  Google Scholar 

  • Bindra D (1978) How adaptive behavior is produced: A perceptual-motivational alternative to response-reinforcement. Behav Brain Sci 1:41–91

    Google Scholar 

  • Blackburn JR, Phillips AG, Jakubovic A, Fibiger HC (1986) Increased dopamine metabolism in nucleus accumbens and striatum following consumption of a nutritive meal but not a palatable non-nutritive sacharin solution. Pharmacol Biochem Behav 25:1095–1100

    Google Scholar 

  • Blackburn JR, Phillips AG, Fibiger HC (1987) Dopamine and preparatory behavior: I. Effects of pimozide. Behav Neurosci 101:352–360

    Google Scholar 

  • Blackburn JR, Phillips AG, Jakubovic A, Fibiger HC (1989a) Dopamine and preparatory behavior: II. A neurochemical analysis. Behav Neurosci 103:15–23

    Google Scholar 

  • Blackburn JR, Phillips AG, Jakubovic A, Fibiger HC (1989b) Dopamine and preparatory behavior. III: A neurochemical analysis. Behav Neurosci 103:15–23

    Google Scholar 

  • Bolles RC (1972) Reinforcement, expectancy and learning. Psychol Rev 79:349–409

    Google Scholar 

  • Bowers W, Hamilton M, Zacharcho RM, Anisman H (1985) Differential effects of pimozide on response-rate and choice accuracy in a self-stimulation paradigm in mice. Pharmacol Biochem Behav 22:521–526

    Google Scholar 

  • Bozarth MA, Wise RA (1981a) Involvement of the ventral tegmental dopamine system in opioid and psychomotor stimulant reinforcement. Life Sci 28:551–555

    Article  PubMed  Google Scholar 

  • Bozarth MA, Wise RA (1981b) Heroin reward is dependent on a dopaminergic substrate. Life Sci 29:1881–1886

    Article  PubMed  Google Scholar 

  • Bozarth MA, Wise RA (1986) Involvement of the ventral tegmental dopamine system in opioid and psychomotor stimulant reinforcement. NIDA Res Monogr Ser 67:190–196

    Google Scholar 

  • Broekkamp CL, van Dongen PA, van Rossum (1977) Neostriatal involvement in reinforcement and motivation. In: Cools AR, Lohman AM, van den Berken JH (eds) Psychobiology of the striatum. Elsevier Holland, Amsterdam

    Google Scholar 

  • Brozoski TJ, Brown RM, Rosvold HE, Goldman PS (1979) Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 205:929–932

    PubMed  Google Scholar 

  • Buchwald NA, Hull CD, Levine MS, Villablanca J (1975) The basal ganglia and the regulation of response and cognitive sets. In: Brazier MA (ed) Growth and development of the brain. Raven Press, New York, pp 171–189

    Google Scholar 

  • Cabanac M (1971) Physiological role of pleasure. Science 173:1103–1107

    PubMed  Google Scholar 

  • Cador M, Robbins TW, Everitt BJ (1989) Involvement of the amygdala in stimulus-reward associations: interactions with the ventral striatum. Neuroscience 30:77–86

    Article  PubMed  Google Scholar 

  • Campbell BA, Sheffield FD (1953) Relation of random activity to food deprivation. J Comp Physiol Psychol 46:320–322

    PubMed  Google Scholar 

  • Carli M, Evenden JL, Robbins TW (1985) Depletion of unilateral striatal dopamine impairs initiation of contralateral actions but not sensory attention. Nature 313:279–282

    Article  Google Scholar 

  • Carli M, Jones GH, Robbins TW (1989) Effects of unilateral dorsal and ventral striatal dopamine depletion on visual neglect in the rat: A neural and behavioral analysis. Neuroscience 29:309–327

    Article  PubMed  Google Scholar 

  • Chen J, Paredes W, Li J, Smith D, Lowison J, Gardner EL (1990) tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis. Psychopharmacology 102:156–162

    Google Scholar 

  • Chiodo LA, Berger TW (1986) Interactions between dopamine and amino acid-induced excitations and inhibition in the striatum. Brain Res 375:198–203

    Article  PubMed  Google Scholar 

  • Church WH, Justice JB, Neill DB (1987) Detecting behaviorally relevant changes in extracellular dopamine with microdialysis. Brain Res 412:397–399

    Article  PubMed  Google Scholar 

  • Clody DE, Carlton PL (1980) Stimulus efficacy, chlorpromazine, and schizophrenia. Psychopharmacology 69:127–131

    Google Scholar 

  • Cofer CN (1972) Motivation and emotion. Scott, Foresman, Glenview, IL

    Google Scholar 

  • Cofer CN, Appley MH (1964) Motivation: theory and research. Wiley, New York

    Google Scholar 

  • Colwill RM, Rescorla RA (1986) Associative structures in instrumental learning. In: Bower GH (ed) The psychology of learning and motivation. Academic Press, New York, pp 55–104

    Google Scholar 

  • Cools AR (1980) Role of neostriatal dopaminergic activity in sequencing and selecting behavioural strategies: facilitation of processes involved in selecting the best strategy in a stressful situation. Behav Brain Res 1:361–378

    Google Scholar 

  • Corradini A, Tombaugh T, Anisman H (1984) Effects of pimozide on escape and discrimination performance in a water-escape task. Behav Neurosci 98:96–106

    Google Scholar 

  • D'Angio MD, Serrano A, Rivy JP, Scatton B (1987) Tail-pinch stress increases extracellular DOPAC levels (as measured by in vivo voltammetry) in rat nucleus accumbens but not frontal cortex: antagonism by diazepam and zolpidem. Brain Res 409:169–174

    Article  PubMed  Google Scholar 

  • Di Chiara G, Imperato A (1986) Preferential stimulation of dopamine release in the nucleus accumbens by opiates, alcohol and barbiturates: studies with transcerebral dialysis in freely moving rats. Ann NY Acad Sci 473:367–381

    PubMed  Google Scholar 

  • Di Scala G, Sander G (1989) Conditioned place aversion produced by FG 7142 is attenuated by haloperidol. Psychoparmacology 99:176–180

    Article  Google Scholar 

  • Divac I (1972) Neostriatum and functions of prefrontal cortex. Acta Neurobiol Exp 32:461–477

    Google Scholar 

  • Duffy E (1963) Activation and behavior. Wiley, New York

    Google Scholar 

  • Dunnett SB, Iversen SD (1982) Sensorimotor impairments following localized kainic acid and 6-hydroxydopamine lesions of the neostriatum. Brain Res 248:121–127

    Article  PubMed  Google Scholar 

  • Edmonds PE, Gallistel CR (1974) Parametric analysis of brain stimulation reward in the rat: effect of performance variables on the reward summation function. J Comp Physiol Psychol 87:876–883

    PubMed  Google Scholar 

  • Ellinwood EH, Kilbey MM (1975) Amphetamine stereotypy — influence of environmental factors and prepotent behavior patterns on its topography. Biol Psychiatry 10:3–16

    PubMed  Google Scholar 

  • Ettenberg A (1989) Dopamine, neuroleptics and reinforced behavior. Neurosci Biobehav Rev 13:105–111

    PubMed  Google Scholar 

  • Ettenberg A, Koob GF, Bloom F (1981) Response artifact in the measurement of neuroleptic-induced anhedonia. Science 209:357–359

    Google Scholar 

  • Ettenberg A, Carlisle HJ (1985) Neuroleptic-induced deficits in operant responding for temperature reinforcement. Pharmacol Biochem Behav 22:761–767

    Google Scholar 

  • Evenden JL, Robbins TW (1983a) Dissociable effects ofd-amphetamine, chlordiazepoxide and alpha-flupenthixol on choice and rate measures of reinforcement in the rat. Psychopharmacology 79:180–186

    Google Scholar 

  • Evenden JL, Robbins TW (1983b) Increased response switching, perseveration and perseverative switching followingd-amphetamine in the rat. Psychopharmacology 80:67–73

    Google Scholar 

  • Evenden JL, Robbins TW (1984) Effects of unilateral 6-hydroxydopamine lesions of the caudate-putamen on skilled forepaw use in the rat. Behav Brain Res 14:61–68

    Google Scholar 

  • Everitt BJ (1990) Sexual motivation: a neural and behavioral analysis of the mechanisms underlying appetitive and copulatory responses of male rats. Neurosci Biobehav Rev 14:217–232

    Google Scholar 

  • Everitt BJ, Cador M, Robbins TW (1989) Interactions between the amygdala and ventral striatum in stimulus-reward associations: studies using a second-order schedule of sexual reinforcement. Neuroscience 30:63–75

    Article  PubMed  Google Scholar 

  • Fada F, Argiolas A, Melis MR, Tissari AH, Onali PC, Gessa GL (1978) Stress-induced increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the cerebral cortex and in nucleus accumbens: reversal by diazepam. Life Sci 23:2219–2224

    Article  Google Scholar 

  • Fairley PC, Marshall JF (1987) Dopamine in the lateral caudate-putamen of the rat is essential for somatosensory orientation. Behav Neurosci 100:652–663

    Google Scholar 

  • Faustman WO, Fowler SC (1981) Use of operant response duration to distinguish effects of haloperidol form non-reward. Pharmacol Biochem Behav 15:327–329

    Google Scholar 

  • Faustman WO, Fowler SC (1982) An examination of methodological refinements, clozapine and fluphenazine in the anhedonia paradigm. Pharmacol Biochem Behav 17:987–993

    Google Scholar 

  • Fibiger HC, Carter DA, Phillips AG (1976) Decreased intracranial self-stimulation after neuroleptics or 6-hydroxydopamine: evidence for mediation by motor deficits rather than by reduced reward. Psychopharmacology 47:21–27

    Google Scholar 

  • Flynn FW, Grill HJ (1983) Insulin elicits injestion in decerebrate rats. Science 221:188–190

    Google Scholar 

  • Fouriezos G, Bielajew C, Pagotto W (1990) Task difficulty increases threshold of rewarding brain stimulation. Behav Brain Res 37:1–7

    Google Scholar 

  • Fowler SC (1990) Neuroleptics produce within-session decrements: facts and theories. Drug Dev Res

  • Fowler SC, Gramling SE, Liao RM (1986a) Effects of primozide on emitted force, duration and rate of operant response maintained at low and high levels of required force. Pharmacol Biochem Behav 25:615–622

    Google Scholar 

  • Fowler SC, LaCerra MM, Ettenberg A (1986b) Effects of haloperidol on the biophysical characteristics of operant responding: implications for motor and reinforcement processes. Pharmacol Biochem Behav 25:791–796

    Google Scholar 

  • Frank R, Williams H (1985) Both response effort and current intensity affect self-stimulation train duration thresholds. Pharmacol Biochem Behav 22:527–530

    Google Scholar 

  • Franklin KBT, McCoy SH (1979) Pimozide-induced extinction in rats: stimulus control of responding rules out motor deficit. Pharmacol Biochem Behav 11:71–75

    Article  PubMed  Google Scholar 

  • Gaddy JR, Neill DB (1977) Differential behavioral changes following intrastiatal applications of 6-hydroxydopamine. Brain Res 119:439–446

    Article  PubMed  Google Scholar 

  • Garcia-Rill E (1986) The basal ganglia and the locomotor regions. Brain Res Rev 11:47–63

    Article  Google Scholar 

  • Glickman SE, Schiff BB (1967) A biological theory of reinforcement. Psychol Rev 74:81–109

    PubMed  Google Scholar 

  • Grabiel AM (1990) Neurotransmitters and neuromodulators in the basal ganglia. TINS 13:244–254

    PubMed  Google Scholar 

  • Gramling SE, Fowler SC (1985) Effects of neuroleptics on rate and duration of operant versus reflexive licking in rats. Pharmacol Biochem Behav 22:541–545

    Google Scholar 

  • Gramling SE, Fowler SC, Collins KR (1984) Some effects of pimozide on nondeprived rats licking sucrose solutions in an anhedonia paradigm. Pharmacol Biochem Behav 21:617–624

    Google Scholar 

  • Gray T, Wise RA (1980) Effects of pimozide on lever-pressing behavior maintained on an intermittent reinforcement schedule. Pharmacol Biochem Behav 12:931–935

    Google Scholar 

  • Hernandez L, Hoebel BG (1988) Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. Life Sci 42:1705–1712

    Article  PubMed  Google Scholar 

  • Herrnstein RJ (1974) Formal properties of the matching law. J Exp Anal Behav 21:159–164

    Google Scholar 

  • Heyman GM (1983) A parametric evaluation of hedonic and motoric effects of drugs: pimozide and amphetamine. J Exp Anal Behav 40:113–122

    Google Scholar 

  • Heyman GM, Monaghan MM (1987) Effects of changes in response requirement and deprivation on the parameters of the matching law equation: new data and review. J Exp Psychol [Anim Behav] 13:384–394

    Google Scholar 

  • Heyman GM, Kinzie DL, Seiden LS (1986) Chlorpromazine and pimozide alter reinforcement efficacy and motor performance. Psychopharmacology 88:346–353

    Google Scholar 

  • Hilgard ER, Marquis DG (1940) Conditioning and learning. Appleton Century, New York

    Google Scholar 

  • Hirata K, Yim CY, Mogenson GJ (1984) Excitatory input from sensory motor cortex to neostriatum and its modification by conditioning stimulation of the substantia nigra. Brain Res 321:1–8

    Article  PubMed  Google Scholar 

  • Hoebel BG, Monaco AP, Hernandez L, Aulisi EF, Stanley BG, Leonard L (1983) Self-injection of amphetamine directly into the brain. Psychopharmacology 81:158–163

    Google Scholar 

  • Hornykiewicz O (1972) Dopamine and its physiological significance in brain function. In: Browne GH (ed) The structure and function of nervous tissue. Academic Press, New York

    Google Scholar 

  • Horvitz JC, Ettenberg A (1989) Haloperidol blocks the response-reinstating effects of food reward: a methodology for separating neuroleptic effects on reinforcement and motor processes. Pharmacol Biochem Behav 31:861–865

    Google Scholar 

  • Hursh SR, Raslear TG, Shurtleff D, Bauman R, Simmons L (1988) A cost-benefit analysis of demand for food. J Exp Anal Behav 50:419–440

    Google Scholar 

  • Imperato A, Di Chiara G (1986) Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol. J Psychol Exp Ther 239:219–228

    Google Scholar 

  • Janssen PA, Niemegeers CJF, Schellekens KHL (1965) Is it possible to predict the clinical effects of neuroleptic drugs (major tranquilizers) from animal data? Arzneimittelforschung 15:104–117

    PubMed  Google Scholar 

  • Jicha GA, Salamone JD (1991) Vacuous jaw movements and feeding deficits in rats with ventrolateral striatal dopamine depletion: Possible relation to Parkinsonian symptoms. J Neurosci 11:3822–3829

    PubMed  Google Scholar 

  • Kaufman LW (1980) Foraging costs and meal patterns in ferrets. Physiol Behav 25:139–141

    Google Scholar 

  • Keefe KA, Salamone JD, Zigmond MJ, Stricker EM (1989) Paradoxical kinesia in Parkinsonism is not caused by dopamine release: studies in an animal model. Arch Neurol 46:1070–1075

    PubMed  Google Scholar 

  • Keehn JD, Riusech R (1977) Schedule-induced water and saccharin polydipsia under haloperidol. Bull Psychonom Soc 9:413–415

    Google Scholar 

  • Kelley AE, Domesick VB (1982) The distribution of the projection from the hippocampal formation to the nucleus accumbens of the rat: an anterograde- and retrograde-horseradish peroxidase study. Neuroscience 7:2321–2335

    Article  PubMed  Google Scholar 

  • Kelley AE, Stinus L (1985) Disappearance of hoarding behavior after 6-hydroxydopamine lesions of the mesolimbic dopamine neurons and its reinstatement with L-dopa. Behav Neurosci 99:531–543

    Article  PubMed  Google Scholar 

  • Kelley AE, Domesick VB, Nauta WJH (1982) The amygdalostriatal projection in the rat- an anatomical study by anterograde and retrograde tracing methods. Neuroscience 7:615–630

    Article  PubMed  Google Scholar 

  • Kelley AE, Winnock M, Stinus L (1986) Amphetamine, apomorphine and investigatory behavior in the rat: Analysis of the structure and pattern of responses. Psychopharmacology 88:66–74

    Article  PubMed  Google Scholar 

  • Kelley AE, Lang CG, Gauthier AM (1988) Induction of oral stereotypy following amphetamine microinjection into a discrete subregion of the striatum. Psychopharmacology 95:556–559

    Google Scholar 

  • Kelly PH, Seviour PW, Iversen SD (1975) Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res 94:507–522

    Article  PubMed  Google Scholar 

  • Killeen P (1975) On the temporal control of behavior. Psychol Rev 82:89–115

    Google Scholar 

  • Killeen P (1981) Incentive theory. In: Bernstein D (ed) Response structure and organization. University of Nebraska Press, Lincoln, Nebraska

    Google Scholar 

  • Kirkpatrick MA, Fowler SC (1989) Force-proportional reinforcement: Pimozide does not reduce rats' emmission of higher forces for sweeter rewards. Pharmacol Biochem Behav 32:499–504

    Google Scholar 

  • Kolb B, Whishaw IQ (1990) Fundamentals of human neuropsychology. W.H. Freeman, New York

    Google Scholar 

  • Koob GF, Riley SJ, Smith SC, Robbins TW (1978) Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat. J Comp Physiol Psychol 92:917–927

    PubMed  Google Scholar 

  • Krebs JR (1978) Optimal foraging: Decision rules for predators. In: Krebs JR, Davies WB (eds) Behavioral ecology. Sinauer Sunderland, MA, pp 23–63

    Google Scholar 

  • Liao RM, Fowler SC (1990) Haloperidol produces within-session increments in operant response duration in rats. Pharmacol Biochem Behav 36:199–201

    Google Scholar 

  • Lidsky TI, Buchwald NA, Manetto C, Schneider JS (1985) A consideration of sensory factors involved in the motor functions of the basal ganglia. Brain Res Rev 9:133–146

    Article  Google Scholar 

  • Ljungberg T (1987) Blockade by neuroleptics of water intake and operant responding in the rat: anhedonia, motor deficit or both? Pharmacol Biochem Behav 27:341–350

    Google Scholar 

  • Ljungberg T (1988) Scopolamine reverses haloperidol-attenuated lever pressing for water but not haloperidol-attenuated water intake in the rat. Pharmacol Biochem Behav 29:205–208

    Google Scholar 

  • Ljungberg T (1989) Effects of the dopamine D-1 antagonist SCH 23390 on water intake, water-rewarded operant responding and apomorphine induced decrease of water in rats. Pharmacol Biochem Behav 33:709–712

    Google Scholar 

  • Ljungberg T (1990) Differential attenuation of water intake and water-rewarded operant responding by repeated administration of haloperidol and SCH 23390 in the rat. Pharmacol Biochem Behav 35:111–115

    Google Scholar 

  • Logan FA (1960) Incentive: How the conditions of reinforcement affect the performance of rats. Yale University Press, New Haven

    Google Scholar 

  • Logan FA, Wagner AR (1965) Reward and punishment. Allyn and Bacon, Boston

    Google Scholar 

  • Lyon M, Randrup A (1972) Dose-response effect of amphetamine upon avoidance behavior in rats seen as a function of increasing stereotypy. Psychopharmacology 23:334

    Google Scholar 

  • Lyon M, Robbins TW (1975) The action of central nervous system stimulant drugs. Curr Dev Psychopharmacol 2:79–163

    Google Scholar 

  • Lynch MR, Carey RJ (1987) Environmental stimulation promotes recovery from haloperidol-induced extinction of open field behavior in rats. Psychopharmacology 92:206–209

    Google Scholar 

  • Mackintosch NJ (1974) The psychology of animal learning. Academic Press, London

    Google Scholar 

  • Mackintosh NJ (1978) Limits on reinterpreting instrumental conditioning in terms of classical conditioning. Behav Brain Sci 1:67

    Google Scholar 

  • Marsden CD (1982) The mysterious motor function of the basal ganglia: the Robert Wartenberg lecture. Neurology 32:514–539

    PubMed  Google Scholar 

  • Marshall JF, Levitan D, Stricker EM (1976) Activation-induced restoration of sensorimotor functions in rats with dopamine-depleting brain lesions. J Comp Physiol Psychol 90:536–546

    PubMed  Google Scholar 

  • Martin-Iverson MT, Wilke D, Fibiger HC (1987) Effect of haloperidol andd-amphetamine on perceived quantitiy of food and tones. Psychopharmacology 93:374–381

    Google Scholar 

  • Mason ST, Beninger RJ, Fibiger HC, Phillips AG (1980) Pimozide-induced suppression of responding: evidence against a block of food reward. Pharmacol Biochem Behav 12:917–923

    Google Scholar 

  • McCullough LD, Singer D, Salamone JD (1990) Periodic food presentation increases extracellular dopamine and metabolites in nucleus accumbens dialysis perfusates. Soc Neurosci Abstr 16:438

    Google Scholar 

  • McDowell JJ, Kessell R (1979) A multivariate rate equation for variable-interval performance. J Exp Anal Behav 31:267–283

    Google Scholar 

  • Meehl PE (1950) On the circularity of the law of effect. Psychol Bull 47:52–75

    Google Scholar 

  • Mekarski JE (1989) Main effects of current and pimozide on prepared and learned self-stimulation behaviors are on performance not reward. Pharmacol Biochem Behav 31:845–853

    Google Scholar 

  • Mittleman G, Whishaw IQ, Jones GH, Koch M, Robbins TW (1990) Cortical, hippocampal, and striatal mediation of schedule-induced behaviors. Behav Neurosci 104:399–409

    Google Scholar 

  • Mogenson G, Jones D, Yim CY (1980) From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 14:69–97

    Article  PubMed  Google Scholar 

  • Mogenson GJ, Yang CR, Yim CY (1988) Influence of dopamine limbic inputs to the nucleus accumbens. Ann NY Acad Sci 537:86–100

    PubMed  Google Scholar 

  • Montgomery KC (1954) The role of the exploratory drive in learning. J Comp Physiol Psychol 44:582–589

    Google Scholar 

  • Morley MJ, Bradshaw CM, Szabadi E (1984) The effect of pimozide on variable-interval performance: a test of the ‘anhedonia’ hypothesis of the mode of neuroleptic action. Psychopharmacology 84:531–536

    Google Scholar 

  • Neafsy EJ, Hull CD, Buchwald NA (1978) Preparation for movement in the cat. II. Unit activity in the basal ganglia and thalamus. Electroencephalogr Clin Neurophysiol 44:714–723

    Google Scholar 

  • Neill DB (1982) Problems of concept and vocabulary in the anhedonia hypothesis. Behav Brain Sci 5:70

    Google Scholar 

  • Neill DB, Justice JB (1981) An hypothesis for a behavioral function of dopaminergic transmission in nucleus accumbens. In: Chronister RB, Defrance JF (eds) The neurobiology of the nucleus accumbens. Huer Institute, Brunswick

    Google Scholar 

  • Niemegeers CJE, Verbruggen FJ, Janssen PAJ (1969) The influence of various neuroleptic drugs on shock avoidance responding in rats. Psychopharmacology 16:161–174

    Google Scholar 

  • Niemegeers CJE, Verbruggen FJ, Janssen PAJ (1970) The influence of various neuroleptic drugs on shock avoidance responding in rats. Psychopharmacology 17:151–159

    Google Scholar 

  • Nishino H, Ono T, Muramoto K, Fukuda M, Sasaki K (1987) Neuronal activity in the ventral tegmental area (VTA) during motivated bar press feeding in the monkey. Brain Res 413:302–313

    Article  PubMed  Google Scholar 

  • Ogden JA, Growden JH, Corkin S (1990) Deficits of visuospatial tests involving forward planning in high-functioning Parkinsonian. Neuropsychiat Neuropsychol Behav Neurol 3:125–139

    Google Scholar 

  • Packard MG, White NM (1991) Dissociation of hippocampus and caudate nucleus memory systems by posttraining intracerebral injection of dopamine agonists. Behav Neurosci 105:295–306

    Google Scholar 

  • Phillips AG, Fibiger HC (1979) Decreased resistance to extinction after haloperidol: Implications for the role of dopamine in reinforcement. Pharmacol Biochem Behav 10:751–761

    Google Scholar 

  • Pisa M (1988a) Motor somatotopy in the striatum of rat: manipulation, biting and gait. Behav Brain Res 27:21–35

    Google Scholar 

  • Pisa M (1988b) Motor functions of the striatum in the rat: critical role of the lateral region in tongue and forelimb reaching. Neuroscience 24:453–463

    Article  PubMed  Google Scholar 

  • Posluns D (1962) An analysis of chlorpromazine-induced suppression of the avoidance response. Psychopharmacology 3:361–373

    Article  Google Scholar 

  • Premack D (1959) Toward empirical behavior laws. I: Positive reinforcement. Psychol Rev 66:219–233

    PubMed  Google Scholar 

  • Rachlin H (1981) Absolute and relative consumption space. In: Bernstein D (ed) Response structure and organization. University of Nebraska Press, Lincoln

    Google Scholar 

  • Redgrave P, Dean P, Donohue TP, Pope SP (1980) Superior colliculus lesions selectively attenuate apomorphine-induced oral stereotypy: a possible role for the nigrotectal pathway. Brain Res 196:541–546

    Article  PubMed  Google Scholar 

  • Rescorla RA (1990) The role of information about the response-outcome relation in instrumental learning. J Exp Psychol [Anim Behav] 16:262–270

    Article  Google Scholar 

  • Robbins TW (1975) The potentiation of conditioned reinforcement by psychomotor stimulant drugs: a test of Hill's hypothesis. Psychopharmacology 45:103–114

    Google Scholar 

  • Robbins TW (1978) The acquisition of responding with conditioned reinforcement: Effects of pipradrol, methylphenidate,d-amphetamine and nomifensine. Psychopharmacology 58:79–87

    Article  Google Scholar 

  • Robbins TW, Everitt BJ (1982) Functional studies of central catecholamines. Int Rev Neurobiol 23:303–364

    PubMed  Google Scholar 

  • Robbins TW, Koob GF (1980) Selective disruption of displacement behaviour by lesions of the mesolimbic dopamine system. Nature 285:409–412

    Article  PubMed  Google Scholar 

  • Rolls ET, Rolls BJ, Kelly PH, Shaw SG, Wood RJ, Dale R (1974) The relative attenuation of self-stimulation, eating and drinking produced by dopamine-receptor blockade. Psychopharmacology 38:219–230

    Google Scholar 

  • Rolls ET, Thorpe SJ, Boytim M, Szabo I, Perret DI (1984) Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness. Neuroscience 12:1201–1212

    Article  PubMed  Google Scholar 

  • Rosenblatt WH, Hutchins K, Sinnamon HM (1979) Pimozide's effects on ICSS depend upon the interaction of reward and effort. Soc Neurosci Abstr 5:350

    Google Scholar 

  • Rowland N, Engle DJ (1977) Feeding and drinking interaction after acute butyrophenone administration. Pharmacol Biochem Behav 7:295–301

    Google Scholar 

  • Sabol KE, Neill DB, Wages SA, Church WH, Justice JB (1985) Dopamine depletion in a striatal subregion disrupts performance of a skilled motor task in the rat. Brain Res 335:33–43

    Article  PubMed  Google Scholar 

  • Sahakian BJ, Sarna GS, Kantameneni BD, Jackson A, Hutson PH, Curzon G (1985) Association between learning and cortical catecholamines in non-drug-treated rats. Psychopharmacology 86:339–343

    Google Scholar 

  • Salamone JD (1986) Different effects of haloperidol and extinction on instrumental behaviors. Psychopharmacology 88:18–23

    Google Scholar 

  • Salamone JD (1987) The actions of neuroleptic drugs on appetitive instrumental behaviors. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology. Plenum Press, New York pp 575–608

    Google Scholar 

  • Salamone JD (1988) Dopaminergic involvement in activational aspects of motivation: effects of haloperidol on schedule-induced activity, feeding and foraging in rats. Psychobiology 16:196–206

    Google Scholar 

  • Salamone JD (1991) Behavioral pharmacology of dopamine systems: a new synthesis. In: Willner P, Scheel-Kruger J (eds) The mesolimbic dopamine system: from motivation to action. Cambridge University Press, Cambridge, England, pp 599–613

    Google Scholar 

  • Salamone JD, Keller RW, Zigmond MJ, Stricker EM (1989) Behavioral activation in rats increases striatal dopamine metabolism measured by dialysis perfusion. Brain Res 487:215–224

    Article  PubMed  Google Scholar 

  • Salamone JD, Johnson CJ, McCullough LD, Steinpreis RE (1990a) Lateral striatal cholinergic mechanisms involved in oral motor activities in the rat. Psychopharmacology 102:529–534

    Google Scholar 

  • Salamone JD, Zigmond MJ, Stricker EM (1990b) Characterization of the impaired feeding behavior in rats given haloperidol or dopamine-depleting brain lesions. Neuroscience 39:17–24

    Article  PubMed  Google Scholar 

  • Salamone JD, Steinpreis RE, McCullough LD, Smith P, Grebel D, Mahan K (1991) Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food-choice procedure. Psychopharmacology 104:515–521

    Google Scholar 

  • Sanders B (1976) Sensitivity to low doses of ethanol and pentobarbital in mice selected for sensitivity to hypnotic doses of ethanol. J Comp Physiol Psychol 90:394–398

    PubMed  Google Scholar 

  • Sanders B, Sharpless SK, Collins AC, McClearn GE, Flanagan C (1978) Activating and anesthetic properties of general depressants. Psychopharmacology 56:185–189

    Google Scholar 

  • Sanger DJ (1986) Response decrement patterns after neuroleptic and non-neuroleptic drugs. Psychopharmacology 89:98–104

    Google Scholar 

  • Scatton B, D'Angio M, Driscoll P, Serrano A (1988) An in vivo voltammetric study of the response of mesocortical and mesoaccumbens dopaminergic neurons to environmental stimuli in strains of rats with differeing levels of emotionality. Ann NY Acad Sci 537:124–137

    PubMed  Google Scholar 

  • Schacter S (1964) The interaction of cognitive and physiological determinants of emotional state. In: Berkowitz L (ed) Advances in experimental social psychology. Academic Press, New York, pp 49–80

    Google Scholar 

  • Schacter S, Singer JE (1962) Cognitive, social and physiological determinants of the emotional state. Psychol Rev 69:379–399

    PubMed  Google Scholar 

  • Schneirla TC (1959) An evolutionary and developmental theory of biphasic processes underlying approach and withdrawal. In: Jones MR (ed) Nebraska Symposium on Motivation. University of Nebraska Press, Lincoln, pp 1–42

    Google Scholar 

  • Schwab RS, Zieper I (1965) Effects of mood, motivation, stress and alertness on the performance in Parkinson's disease. Psychiat Neurol 150:345–357

    Google Scholar 

  • Schwab RS, Chaftez ME, Walker S (1954) Control of two simultaneous motor acts in normals and parkinsonism. Arch Neurol 72:591–598

    Google Scholar 

  • Simon H, Le Moal M (1988) Mesencephalic dopaminergic neurons: role in the general economy of the brain. Ann NY Acad Sci 537:235–253

    PubMed  Google Scholar 

  • Simon H, Scatton B, Le Moal M (1980) Dopaminergic A10 neurons are involved in cognitive function. Nature 286:150–151

    Article  PubMed  Google Scholar 

  • Sinnamon HM (1982) The reward-effort model: an economic framework for examining the mechanism of neuroleptic action. Behav Brain Sci 5:73–75

    Article  Google Scholar 

  • Spence KW (1956) Behavior theory and conditioning. Yale University Press, New Haven

    Google Scholar 

  • Spivak KJ, Amit Z (1986) Effects of pimozide on appetitive behavior and locomotor activity: dissimilarity of effects when compared to extinction. Physiol Behav 36:457–463

    Google Scholar 

  • Spyraki C, Fibiger HC (1988) A role for the mesolimbic dopamine system in the reinforcing properties of diazepam. Psychopharmacology 94:133–137

    Article  PubMed  Google Scholar 

  • Spryaki C, Fibiger HC, Phillips AG (1982) Attenuation by haloperidol of place preference conditioning using food reinforcement. Psychopharmacology 77:379–382

    Article  PubMed  Google Scholar 

  • Spryaki C, Fibiger HC, Phillips AG (1983) Attenuation of heroin reward in rats by disruption of mesocorticolimbic dopamine system. Psychopharmacology 79:278–283

    Article  PubMed  Google Scholar 

  • Staddon JE (1979) Operant behavior as adaptation to constraint. J Exp Psychol Gen 108:48–67

    Article  Google Scholar 

  • Staddon JE, Simmelhag VL (1971) The superstition experiment: a re-examination of its implications for the principles of adaptive behavior. Psycho Rev 78:3–43

    Google Scholar 

  • Steinfels GF, Heym J, Strecker RE, Jacobs BL (1983) Behavioral correlates of dopaminergic unit activity in freely moving cats. Brain Res 258:217–228

    Article  PubMed  Google Scholar 

  • Stokes PD, Balsam PD (1991) Effects of reinforcing preselected approximations on the topography of the rat's bar press. J Exp Anal Behav 55:213–231

    Google Scholar 

  • Stricker EM, Zigmond MJ (1976) Recovery of function after damage to central catecholamine-containing neurons: a neurochemical model for the lateral hypothalamic syndrome. In: Sprague JM (ed) Progress in psychobiology and physiological psychology. Academic Press, New York, pp 121–173

    Google Scholar 

  • Stricker EM, Zigmond MJ (1984) Brain catecholamines and the central control of food intake. Int J Obesity 8 [suppl 1]:39–50

    Google Scholar 

  • Swanson LW, Mogenson GJ, Gerfen CR, Robinson P (1984) Evidence for a projection from the lateral preoptic area and substantia innominata to the “mesencephalic locomotor region”. Brain Res 295:161–178

    Article  PubMed  Google Scholar 

  • Taha EB, Dean P, Redgrave P (1982) Oral behavior induced by intranigral muscimol is unaffected by haloperidol but abolished by large lesions of superior colliculus. Psychopharmacology 77:272–278

    Google Scholar 

  • Taylor JR, Robbins TW (1984) Enhanced behavioral control by conditioned reinforcers following microinjections of D-amphetamine into the nucleus accumbens. Psychopharmacology 84:405–412

    Article  Google Scholar 

  • Taylor JR, Robbins TW (1986) 6-Hydroxydopamine lesions of the nucleus accumbens but not the caudate nucleus attenuate responding with reward-related stimului produced by intra-accumbens D-amphetamine. Psychopharmacology 90:390–397

    Google Scholar 

  • Teuber H-L, Proctor F (1964) Some effects of basal ganglia lesions in subhuman primates and man. Neuropsychology 2:85–93

    Article  Google Scholar 

  • Thierry AM, Tassin JP, Blanc G, Glowinski J (1976) Selective activation of mesocortical dopaminergic system by stress. Nature 263:242–244

    Article  PubMed  Google Scholar 

  • Thorndike EL (1911) Animal intelligence. MacMillan, New York

    Google Scholar 

  • Timberlake W, Allison J (1974) Response deprivation: an empirical approach to instrumental performance. Psychol Rev 81:146–164

    Google Scholar 

  • Tombaugh TN, Anisman H, Tombaugh J (1980) Extinction and dopamine receptor blockade after intermittent reinforcement training: failure to observe functional equivalence. Psychopharmacology 70:19–28

    Google Scholar 

  • Tombaugh TN, Szostak C, Mills P (1983) Failure of pimozide to disrupt acquisition of light-dark and spatial discrimination problems. Psychopharmacology 79:161–168

    Google Scholar 

  • Ungerstedt U (1971) Aphagia and adipsia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand 82 [suppl 367]:95–122

    Google Scholar 

  • Ungerstedt U, Ljungberg T (1974) Central dopamine neurons and sensory processing. J Psychiatr Res 55:149–150

    Article  Google Scholar 

  • Vaccarino FJ, Franklin KBJ, Prupas D (1985a) Opposite locomotor asymmetries elicited from the medial and lateral substantia nigra: Role of superior colliculus. Physiol Behav 35:741–747

    Google Scholar 

  • Vaccarino FJ, Franklin KBJ, Prupas D (1985b) The role of the midbrain reticular formation in the expression of two opposing nigral denervation syndromes. Physiol Behav 35:749–752

    Google Scholar 

  • Vives F, Mogenson GJ (1986) Electrophysiological study of the effects of D1 and D2 dopamine antagonists on the interaction of converging inputs from the sensory motor cortex and substantia nigra neurons in the rat. Neuroscience 17:349–359

    Article  PubMed  Google Scholar 

  • Weiner I (1990) Neural substrates of latent inhibition: the switching model. Psychol Bull 108:442–461

    Article  PubMed  Google Scholar 

  • Weiner I, Feldon J, Katz Y (1987) Facilitation of the expression but not the acquisition of latent inhibition by haloperidol in rats. Pharmacol Biochem Behav 26:241–246

    Google Scholar 

  • Whishaw IQ, O'Connor WT, Dunnet SB (1986) The contributions of motor cortex, nigrostriatal dopamine and caudate-putamen to skilled forelimb use in the rat. Brain 109:805–843

    PubMed  Google Scholar 

  • White NM (1986) Control of sensorimotor functions by dopaminergic nigrostriatal neurons: influence on eating and drinking. Neurosci Biobehav Rev 10:15–36

    Article  PubMed  Google Scholar 

  • White NM (1988) Effect of nigrostriatal dopamine depletion on the post-training, memory-improving action of amphetamine. Life Sci 43:7–12

    Article  PubMed  Google Scholar 

  • Willner P (1985) Depression: a psychobiological synthesis. Wiley, New York

    Google Scholar 

  • Willner P, Chawala K, Sampson D, Sophokleus S, Muscat R (1988) Tests

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Salamone, J.D. Complex motor and sensorimotor functions of striatal and accumbens dopamine: involvement in instrumental behavior processes. Psychopharmacology 107, 160–174 (1992). https://doi.org/10.1007/BF02245133

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