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Abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis

  • Motility, Nerve-Gut Interactions, Hormones, And Receptors
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Abstract

Gastric myoelectrical activity modulates gastric motor activity. Abnormalities in gastric myoelectrical activity may be associated with gastric motility disorders. The aim of this study was to investigate the correlation of gastric myoelectrical activity with gastric emptying in symptomatic patients with and without gastroparesis. Ninety-seven patients with symptoms suggestive of gastroparesis participated in the study. Gastric myoelectrical activity was recorded using surface electrogastrography. The electrogastrogram (EGG) was recorded for 30 min in the fasting state and for 120 min after a solid test meal. Gastric emptying of the solid meal was simultaneously monitored for 120 min. Patients with delayed gastric emptying showed a significantly lower percentage of normal gastric slow waves (P<0.03) and a significantly reduced increase of the dominant power in the postprandial EGG (P<0.02). Postprandial EGG parameters were found to be able to predict delayed emptying of the stomach. Postprandial gastric dysrhythmia predicts delayed gastric emptying with an accuracy of 78%, while the abnormality in postprandial EGG power predicts delayed gastric emptying with an accuracy of 75%. All patients with abnormalities in both the rhythmicity and the power had delayed gastric emptying. Patients with delayed gastric emptying have a lower percentage of normal gastric slow waves in the EGG and a lower postprandial increase in the dominant power. Abnormalities in the postprandial EGG seem to be able to predict delayed emptying of the stomach. However, a normal EGG does not seem to guarantee normal emptying of the stomach.

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Author notes

  1. J. D. Z. Chen PhD

    Present address: Thomas N. Institute for Healthcare Research, Integris Baptist Medical Center of Oklahoma, 3300 Northwest Expressway, 73112, Oklahoma City, Oklahoma

Authors and Affiliations

  1. Department of Medicine, From the University of Virginia Health Science Center, Charlottesville, Virginia

    J. D. Z. Chen PhD, Zhiyue Lin MS, Jie Pan MD & Richard W. McCallum MD

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  1. J. D. Z. Chen PhD
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  2. Zhiyue Lin MS
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  3. Jie Pan MD
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  4. Richard W. McCallum MD
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Chen, J.D.Z., Lin, Z., Pan, J. et al. Abnormal gastric myoelectrical activity and delayed gastric emptying in patients with symptoms suggestive of gastroparesis. Digest Dis Sci 41, 1538–1545 (1996). https://doi.org/10.1007/BF02087897

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  • DOI: https://doi.org/10.1007/BF02087897

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