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Pulmonary and systemic vascular response to promethazine in conscious lambs

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Summary

Promethazine is an antihistamine commonly used for sedation in clinical pediatric medicine. We studied the cardiovascular effects of promethazine in normoxic, conscious, chronically instrumented neonatal lambs. Eight lambs received 1.3 mg/kg of promethazine intravenously (i.v.) while at rest. In all lambs, promethazine led to elevations of pulmonary vascular resistance, mean pulmonary arterial pressure, mean transpulmonary pressure, mean left atrial pressure, and the ratio of pulmonary-to-systemic vascular resistance. In addition, five (63%) of the lambs demonstrated an increase in mean systemic arterial pressure and systemic vascular resistance to promethazine. A subgroup of three lambs, which tended to be younger, failed to demonstrate the systemic vascular response to promethazine. Promethazine given i.v. has important cardiovascular effects. We hypothesize that promethazine used for sedation before cardiac catheterization in children may alter subsequent hemodynamic observations.

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Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine, Gainesville

    Robert F. Covert & Willa H. Drummond

  2. Division of Neonatology, Humana Hospital, Brandon

    Iva B. Webb

  3. Division of Biostatistics, Department of Statistics, University of Florida, Gainesville, Florida, USA

    Phyllis A. Gimotty

Authors
  1. Robert F. Covert
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  2. Willa H. Drummond
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  3. Iva B. Webb
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  4. Phyllis A. Gimotty
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Additional information

Dr. Gimotty is now located at Michigan Cancer Foundation, 110 East Warren Avenue, Detroit, Michigan, USA.

This research was performed at the University of Florida.

A portion of this research was presented at the Southern Society for Pediatric Research in New Orleans, Louisiana, USA, January 1981.

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Covert, R.F., Drummond, W.H., Webb, I.B. et al. Pulmonary and systemic vascular response to promethazine in conscious lambs. Pediatr Cardiol 9, 137–141 (1988). https://doi.org/10.1007/BF02080553

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