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The effect of immunomodulating drugs on adjuvant-induced arthritis in Lewis rats

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Abstract

The purpose of this study was to investigate the effects of cyclosporine A (CSA) and methotrexate (MTX) as potential immunomodulators in a nonestablished adjuvant arthritis (AA) model. Non-injected hind paw volumes were reduced when AA rats were treated for 18 dayswith CSA (100% at 10 mg/kg) or MTX (100% at 0.1 mg/kg). Body weights of drug treated AA rats were increased above untreated AA rats and were similar to non-arthritic controls. AA rats show elevated T helper (W3/25+)/T suppressor (OX 8+) cell ratios (2.0 vs. 3.1,p<0.01). The immunomodulators tested all returned these elevated ratios to control non-arthritic levels. Similarly, these drugs returned the reduced mitogen responses and elevated blood granulocyte numbers toward normal non-arthritic control values.

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Authors and Affiliations

  1. Medical Products Department, Experimental Station, E. I. Du Pont de Nemours & Co., Box 80400, 19880-0400, Wilmington, DE, USA

    B. D. Jaffee, J. S. Kerr, E. A. Jones, J. V. Giannaras, M. McGowan & N. R. Ackerman

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  1. B. D. Jaffee
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  2. J. S. Kerr
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  3. E. A. Jones
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  4. J. V. Giannaras
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  5. M. McGowan
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  6. N. R. Ackerman
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Jaffee, B.D., Kerr, J.S., Jones, E.A. et al. The effect of immunomodulating drugs on adjuvant-induced arthritis in Lewis rats. Agents and Actions 27, 344–346 (1989). https://doi.org/10.1007/BF01972818

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  • DOI: https://doi.org/10.1007/BF01972818

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