Skip to main content
Log in

Accumulation of blood platelets in carrageenin rat paw oedema. Possible role in the inflammatory process

  • Immunosuppression and Inflammation
  • Published:
Agents and Actions Aims and scope Submit manuscript

Abstract

The accumulation of blood platelets in the carrageenin-induced paw oedema in rats was studied, using51Cr-labeled platelets. A maximum in the accumulation was seen after 4 hours, followed by a decline after 5–6 hours. During the first 6 hours of the oedema formation, changes in blood volume were small. A comparison was made with the accumulation of both125J-albumin as a measure of extravasation and125J-fibrinogen as an indication of blood clotting. When platelet aggregation was measured during the first 6 hours of the oedema formation, the lag time between the addition of collagen and the beginning of the aggregation was increased. No change in platelet serotonin was seen. These data support the idea that platelets participate in the inflammatory process.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M.J. Silver, J.B. Smith andC.M. Ingerman,Blood Platelets and the Inflammatory Process, Agents and Actions4, 233–239 (1974).

    PubMed  Google Scholar 

  2. M.J.H. Smith, J.B. Walker, A.W. Ford-Hutchinson andD.S. Denington,Platelets, Prostaglandins and Inflammation. Agents and Actions6, 701–704 (1976).

    PubMed  Google Scholar 

  3. J.E. Vincent, I.L. Bonta andF.J. Zijlstra,Platelets and Mediators in the Carrageenin Rat Paw Oedema. Agents and Actions, Suppl 2, 41 (1977).

    Google Scholar 

  4. S.R. Turner, J.A. Turner andW.S. Lynn,Biogenesis of Chemotactic Molecules by the Arachidonate Lipoxygenase System of Platelets, Nature, Lond.257, 680–681 (1975).

    Google Scholar 

  5. A. J. Collins, D. Crook, R. Chan andP.A. Beacon,Prostaglandin-Synthetase Activity in Synovial Tissue from Patients with Rheumatoid Arthritis After Therapy with Aspirin-like Drugs, in:The Role of Prostaglandins in Inflammation (Hans Huber, Vienna, 1976), pp. 138–147.

    Google Scholar 

  6. D.R. Swinson, A. Bennet andR.B.D. Hamilton,Synovial Prostaglandins in Joint Disease, in:The Role of Prostaglandins in Inflammation (Hans Huber, Vienna, 1976), pp. 41–46.

    Google Scholar 

  7. I.L. Bonta, H. Chrispijn, J. Noordhoek andJ.E. Vincent,Reduction of Prostaglandin-Phase in Hind-Paw Inflammation and Partial Failure of Indomethacin to Exert Anti-Inflammatory Effect in Rats on Essential Fatty Acid Deficient Diet, Prostaglandins5, 495–503 (1974).

    PubMed  Google Scholar 

  8. J.E. Vincent, F.J. Zijlstra andI.L. Bonta,The Effect of Non-Steroid Anti-Inflammatory Drugs, Dibutyryl Cyclic 3 o,5 o -Adenosine Monophosphate and Phosphodiesterase Inhibitors on Platelet Aggregation and the Platelet Release Reaction in Normal and Essential Fatty Acid Deficient Rats, Prostaglandins10, 899–911 (1975).

    Article  PubMed  Google Scholar 

  9. G.H.R. Rao, J.G. White, A.A. Jachimowicz andC.J. Witkop,An Improved Method for the Extraction of Endogenous Platelet Serotonin, J. Lab. Clin. Med.87, 129–137 (1976).

    PubMed  Google Scholar 

  10. M. Hamberg, J. Svensson andB. Samuelsson,Thromboxanes: A New Group of Biologically Active Compounds Derived from Prostaglandin Endoperoxides, Proc. Nat. Acad. U.S.A.72, 2994 (1975).

    Google Scholar 

  11. R.J. Perper, M. Sanda, G. Chinea andA.L. Oronsky Leucocyte Chemotaxis in vivo. I. Description of a Model of Cell Accumulation using Adoptively Transferred 51 Cr-labeled Cells. J. Lab. Clin. Med.84, 378–393 (1974).

    PubMed  Google Scholar 

  12. B.B. Vargaftig,Carrageenan and Thrombin Trigger Prostaglandin Synthetase-Independent Aggregation of Rabbit Platelets: Inhibition by Phospholipase A 2 Inhibitors, J. Pharm. Pharmac.29, 222–228 (1977).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vincent, J.E., Bonta, I.L. & Zijlstra, F.J. Accumulation of blood platelets in carrageenin rat paw oedema. Possible role in the inflammatory process. Agents and Actions 8, 291–295 (1978). https://doi.org/10.1007/BF01966617

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01966617

Keywords

Navigation