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Powerful hepatoprotective and hepatotoxic plant oligostilbenes, isolated from the Oriental medicinal plantVitis coignetiae (Vitaceae)

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Abstract

The methanol extract of the Oriental medicinal plantVitis coignetiae (Vitaceae) showed hepatoprotective activity in the in vitro assay method using primary cultured rat hepatocytes. Activity-guided fractionation of the extract afforded ɛ-viniferin as an active principle. The protective effect of ɛ-viniferin against mice carbon tetrachloride-induced hepatic injury in mice was shown by serum enzyme assay as well as by pathological examination. In addition to ɛ-viniferin, plant oligostilbenes, ampelopsins A, C, F and the mixture of vitisin A andcis-vitisin A were also present in the extract. Among them, ampelopsin C and the mixture of vitisin A andcis-vitisin A were found to be powerful hepatotoxins.

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Authors and Affiliations

  1. Department of Pharmaceutical Molecular Biology, Pharmaceutical Institute, Tohoku University, Aoba, Aoba-ku, 980, Sendai, Japan

    Y. Oshima, K. Namao, A. Kamijou, S. Matsuoka & Y. Ohizumi

  2. Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 280, Shingai, Chiba, Japan

    M. Nakano & K. Terao

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  1. Y. Oshima
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  2. K. Namao
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  3. A. Kamijou
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  4. S. Matsuoka
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  5. M. Nakano
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  6. K. Terao
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  7. Y. Ohizumi
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Oshima, Y., Namao, K., Kamijou, A. et al. Powerful hepatoprotective and hepatotoxic plant oligostilbenes, isolated from the Oriental medicinal plantVitis coignetiae (Vitaceae). Experientia 51, 63–66 (1995). https://doi.org/10.1007/BF01964921

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  • DOI: https://doi.org/10.1007/BF01964921

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