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Activation by S-adenosylhomocysteine of norepinephrine and serotonin in vitro uptake in synaptosomal preparations from rat brain

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Summary

S-Adenosylhomocysteine (10−7−10−5 M) activated norepinephrine (NE) and serotonin (5HT) in vitro uptake in synaptosomal preparations from rat brain, but did not affect dopamine (DA) uptake. When administered to rats (7 mg/kg i.p.), it had the same effect on in vitro NE and 5HT uptake. It did not affect NE and 5HT release.

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Work achieved within the frame of the research contract institut Mérieux., Institut National des Sciences Appliquées.

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Fonlupt, P., Roche, M., Cronenberger, L. et al. Activation by S-adenosylhomocysteine of norepinephrine and serotonin in vitro uptake in synaptosomal preparations from rat brain. Experientia 35, 1089–1090 (1979). https://doi.org/10.1007/BF01949959

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