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Involvement of purine compounds in the inotropic action of milrinone

  • Congestive Heart Failure
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Summary

In spontaneously beating atria from reserpinetreated guinea pigs, milrinone (1–100 μg/ml) induced a positive inotropic and chronotropic effect but was ineffective in preparations preincubated with adenosine deaminase (1 U/ml). Both in spontaneously beating and in electrically driven atria, ATP and adenosine evoked a dual effect: a first negative phase characterized by a reduction in contractile force, followed by a positive phase of increased inotropism. In these preparations milrinone inhibited the early negative influence exerted by purine compounds and amplified the following positive phase. These data suggest that the positive inotropic and chronotropic effect of milrinone may originate from its interference with endogenous purines.

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Authors and Affiliations

  1. Department of Pharmacology, University of Padua, Largo E. Menethetti 2, 35131, Padova, Italy

    P. Dorigo, R. M. Gaion & I. Maragno

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  1. P. Dorigo
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  2. R. M. Gaion
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  3. I. Maragno
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Dorigo, P., Gaion, R.M. & Maragno, I. Involvement of purine compounds in the inotropic action of milrinone. Cardiovasc Drug Ther 4, 509–513 (1990). https://doi.org/10.1007/BF01857762

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