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Gastric protection by misoprostol against 1300 mg of aspirin

An endoscopic study

  • Prostaglandins in the Upper Gastrointestinal Tract: Focus on Misoprostol
  • Cytoprotective Effect of Misoprostol (Clinical Studies)
  • Published:
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Abstract

Misoprostol, a synthetic prostaglandin E1 analog is being evaluated in the treatment of peptic ulcer. It has been reported to have both antisecretory and cytoprotective properties. In this placebo-controlled, double-blind study, pretreatment with 200-μg doses of misoprostol was evaluated in the prevention of gastric injury caused by aspirin. Five oral doses of misoprostol or placebo were administered over 24 hr followed by a single oral 1296-mg dose of aspirin 30 min after the fifth dose of test agent. Two hours later the gastric mucosa was examined with a small-caliber fiberendoscope. Protection was defined as no more than 10 petechiae and no more than two hemorrhagic streaks in the gastric mucosa. Twenty of 30 (67%) subjects who received misoprostol was protected, whereas only one of 30 (3%) subjects receiving placebo was protected. The difference between the effects of misoprostol and placebo was highly significant (P<0.001). We concluded that five 200-μg doses of misoprostol given over 24 hr protects the gastric mucosa from the injurious effect of a single dose of aspirin.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, University of Washington, 98195, Seattle, Washington

    Fred E. Silverstein MD, Michael B. Kimmey MD, David R. Saunders MD & Douglas S. Levine MD

Authors
  1. Fred E. Silverstein MD
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  2. Michael B. Kimmey MD
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  3. David R. Saunders MD
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  4. Douglas S. Levine MD
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Additional information

Financial support was provided by G. D. Searle & Co., NIH Training Grant 5 T32 AMO 7113-11, NIH Program Project Grant P01 AM32971, and Fujinon Instrument Company.

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Silverstein, F.E., Kimmey, M.B., Saunders, D.R. et al. Gastric protection by misoprostol against 1300 mg of aspirin. Digest Dis Sci 31 (Suppl 2), 137S–141S (1986). https://doi.org/10.1007/BF01309339

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