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Biochemical and functional evidence for a marked dopamine releasing action of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (NMPTP) in mouse brain

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Summary

The acute effects of N-methyl-4-phenyl-l, 2, 3, 6-tetrahydropyridine (NMPTP) on mouse central monoaminergic neurons were investigated. In striatum, two hours after the injection of NMPTP (50 mg/kg s.c.) there was a seven-fold increase in 3-methoxytyramine that coincided with a 55 % decrease in dopamine. In addition, the same dose of NMPTP caused an acute increase in mouse motor activity; this effect was antagonized by haloperidol or by pretreatment with reserpine.

These data indicate that NMPTP initially causes a pronounced release of dopamine into the extraneuronal space.

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Pileblad, E., Nissbrandt, H. & Carlsson, A. Biochemical and functional evidence for a marked dopamine releasing action of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (NMPTP) in mouse brain. J. Neural Transmission 60, 199–203 (1984). https://doi.org/10.1007/BF01249093

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  • DOI: https://doi.org/10.1007/BF01249093

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