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Hypothermia induced by m-trifluoromethylphenylpiperazine or m-chlorophenylpiperazine: an effect mediated by 5-HT1B receptors?

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Summary

In the present study we examined the effect of different drugs on the m-trifluoromethylphenylpiperazine (TFMPP)- and m-chlorophenylpiperazine (m-CPP)-induced hypothermia in mice. Both the hypothermias studied are blocked or reversed by pindolol, cyanopindolol and compound 21-009, but not by atenolol. Neither hypothermia is antagonized by 5-HT1A antagonists (ipsapirone, spiperone), a 5-HT1C antagonist (mesulergine), 5-HT2 antagonists (cyproheptadine, mianserin, methysergide), 5-HT3 antagonists (ICS 205930, metoclopramide). The examined hypothermias are not antagonized by other antihypothermic agents (pimozide, idazoxan, atropine). The 8-OH-DPAT-induced hypothermia is not affected by cyanopindolol or compound 21009. The obtained results indicate that the TFMPP- and m-CPP-induced hypothermias in mice are mediated by 5-HT1B. These hypothermias may be a good screening test for evaluation of the 5-HT1B-agonistic and 5-HT1B-antagonistic activity.

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  1. J. Maj

    Present address: Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland

Authors and Affiliations

  1. Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland

    E. Chojnacka-Wójcik, A. Kłodzińska, A. Dereń & E. Moryl

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  2. E. Chojnacka-Wójcik
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  3. A. Kłodzińska
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  4. A. Dereń
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Maj, J., Chojnacka-Wójcik, E., Kłodzińska, A. et al. Hypothermia induced by m-trifluoromethylphenylpiperazine or m-chlorophenylpiperazine: an effect mediated by 5-HT1B receptors?. J. Neural Transmission 73, 43–55 (1988). https://doi.org/10.1007/BF01244621

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  • DOI: https://doi.org/10.1007/BF01244621

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