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Gastric inhibitory polypeptide (GIP)

Intestinal distribution and stimulation by amino acids and medium-chain triglycerides

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Abstract

Radioimmunoassayable gastric inhibitory polypeptide was measured in extracts of canine antrum, duodenum, jejunum, and ileum. The highest GIP concentrations were found in the duodenum (347±53 ng/g) and jejunum (300±68 ng/g). An immunochemical similarity was demonstrable between porcine GIP and canine GIP. Dogs prepared with Mann-Bollman fistulae were given an amino acid (AA) mixture or medium-chain triglycerides (MTC) by intraduodenal perfusion. With AA, a peak mean serum concentration of 672±106 pg/ml was reached 15 min after starting the perfusion. MCT resulted in a peak mean serum GIP concentration of 504±55 pg/ml 30 min after beginning the perfusion. When compared to results previously reported from this laboratory, AA and MCT are not as potent as corn oil (long-chain triglyceride) or glucose in stimulating GIP release. We conclude: (1) Immunoassayable GIP concentrations are highest in the canine proximal small intestine. (2) AA and MCT are weak stimulants of GIP release in the dog.

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This study was supported in part by the Bremer Foundation, 521532-7308, the National Institute of Arthritis and Metabolic Disease 5T01-AM05118-19, and General Clinical Research Center Program, National Institutes of Health RR-34, and National Cancer Institute 5F22-CA00776-02.

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O'Dorisio, T.M., Cataland, S., Stevenson, M. et al. Gastric inhibitory polypeptide (GIP). Digest Dis Sci 21, 761–765 (1976). https://doi.org/10.1007/BF01073027

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  • DOI: https://doi.org/10.1007/BF01073027

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