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Do you need a pharmacokinetic model, and, if so, which one?

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References

  1. L. Z. Benet. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.J. Pharm. Sci. 61:536–541 (1972).

    Article  CAS  PubMed  Google Scholar 

  2. L. Michaelis and M. L. Menten. Die Kinetik der Invertinwirkung.Biochem. Z. 49:333–369 (1913).

    CAS  Google Scholar 

  3. A. R. DiSanto and J. G. Wagner. Pharmacokinetics of highly ionized drugs. III. Methylene blue-blood levels in the dog and tissue levels in the rat following intravenous injection.J. Pharm. Sci. 61:1090–1094 (1972).

    Article  CAS  PubMed  Google Scholar 

  4. J. G. Wagner.Biopharmaceutics and Relevant Pharmocokinetics, Drug Intelligence Publications, 1st ed., Hamilton, Ill., 1971, pp. 302–317.

    Google Scholar 

  5. A. J. Sedman and J. G. Wagner. Quantitative pooling of Michaelis-Menten equations with parallel metabolite formation paths.J. Pharmacokin. Biopharm. 2:149–160 (1974).

    Article  CAS  Google Scholar 

  6. K. B. Bischoff, R. L. Dedrick, D. S. Zaharko, and J. A. Longstreth. Methotrexate pharmacokinetics.J. Pharm. Sci. 60:1128–1133 (1971).

    Article  CAS  PubMed  Google Scholar 

  7. J. C. K. Loo and S. Riegelman. A new method for calculating intrinsic absorption rates of drugs.J. Pharm. Sci. 57:918–928 (1968).

    Article  CAS  PubMed  Google Scholar 

  8. J. G. Wagner. Application of the Loo-Riegelman absorption method.J. Pharmacokin. Biopharm. 3:51–67 (1975).

    Article  CAS  Google Scholar 

  9. J. G. Wagner and E. Nelson. Percent absorbed time plots derived from blood level and/or urinary excretion data.J. Pharm. Sci. 52:610–611 (1963).

    Article  CAS  PubMed  Google Scholar 

  10. J. G. Wagner. Application for the Wagner-Nelson absorption method to the two compartment open model.J. Pharmacokin. Biopharm. 2:469–486 (1974).

    Article  CAS  Google Scholar 

  11. K. S. Albert, A. J. Sedman, and J. G. Wagner. Pharmacokinetics of orally administered acetaminophen in man.J. Pharmacokin. Biopharm. 2:381–393 (1974).

    Article  CAS  Google Scholar 

  12. M. Rowland. Influence of route of administration on drug bioavailability.J. Pharm. Sci. 67:70–74 (1972).

    Article  Google Scholar 

  13. K. S. Albert, M. R. Hallmark, E. Sakmar, D. J. Weidler, and J. G. Wagner. Pharmacokinetics of diphenhydramine in man.J. Pharmacokin. Biopharm. 3:159–170 (1975).

    Article  CAS  Google Scholar 

  14. J. G. Wagner. Method of estimating relative absorption of a drug in a series of clinical studies in which blood levels are measured after single and/or multiple doses.J. Pharm. Sci. 56:652–653 (1967).

    Article  CAS  PubMed  Google Scholar 

  15. A. Rescigno and G. Segre.Drug and Tracer Kinetics, Blaisdell, Waltham, Mass., 1966, p. 102.

    Google Scholar 

  16. L. Z. Benet and C.-W. N. Chiang. The use of deconvolution methods in pharmacokinetics. InAbstracts of Papers presented at the 13thNational Meeting of the APhA Academy of Pharmaceutical Sciences, Chicago, November 5–9, 1972, Vol. 2, No. 2, pp. 169–171.

  17. J. Fried and S. Zeitz. Curve fitting by spline and Akima methods: Possibility of interpolation errors and its suppression.Phys. Biol. Med. 18:550–558 (1973).

    Article  CAS  Google Scholar 

  18. AUTOAN, a Time-Sharing Digital Computer Program, available from Publication Distribution Service, 615 East University Avenue, Ann Arbor, Mich. 48106.

  19. E. Krüger-Thiemer. Formal theory of drug dosage regimens. I.J. Theor. Biol. 13:212 (1966).

    Article  Google Scholar 

  20. W. J. Jusko, S. J. Szefler, and A. L. Goldfarb. Pharmacokinetic design of digoxin dosage regimens in relation to renal function.J. Clin. Pharmacol. 14:525–535 (1974).

    Article  CAS  PubMed  Google Scholar 

  21. J. G. Wagner, J. I. Northam, G. D. Alway, and O. S. Carpenter. Blood levels of drug at the equilibrium state after multiple dosing.Nature 207:1301–1302 (1965).

    Article  CAS  PubMed  Google Scholar 

  22. J. G. Wagner. Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics.J. Pharmacokin. Biopharm. 1:103–121 (1973).

    Article  CAS  Google Scholar 

  23. C. A. M. Van Ginneken, J. M. Van Rossum, and H. L. J. M. Fleuren. Linear and nonlinear kinetics of drug elimination. I. Kinetics on the basis of a single capacity-limited pathway of elimination with and without simultaneous supply-limited elimination.J. Pharmacokin. Biopharm. 2:395–415 (1974).

    Article  Google Scholar 

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Wagner, J.G. Do you need a pharmacokinetic model, and, if so, which one?. Journal of Pharmacokinetics and Biopharmaceutics 3, 457–478 (1975). https://doi.org/10.1007/BF01059477

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