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γ-Hydroxybutyric acid binding sites: Interaction with the GABA-benzodiazepine-picrotoxin receptor complex

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Abstract

The effect of three compounds known to allosterically modulate binding to the GABA/benzodiazepine/picrotoxin receptor complex on 4-hydroxy-2,3 [3H]butyric acid (GHB) binding was investigated. Pentobarbital, pentylenetetrazole, and picrotoxin enhanced [3H]GHB binding in a dose dependent fashion. Pentobarbital enhanced 4-hydroxy-2,3 [3H]butyric acid binding was associated with an increase in Bmax while pentylenetetrazole and picrotoxin altered the affinity of GHB for its binding site producing a decrease in Kd. These findings suggest that the GHB and GABA receptor complex may share certain moieties in common.

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Authors and Affiliations

  1. Division of Neurology Childrens Hospital Los Angeles and Department of Neurology University of Southern California School of Medicine Los Angeles, 4650 Sunset Blvd, No. 42, 90027, Los Angeles, California

    O. Carter Snead III & Chun Che Liu

  2. University of Texas Medical Branch, Galveston, Texas

    A. C. Nichols

Authors
  1. O. Carter Snead III
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  2. A. C. Nichols
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  3. Chun Che Liu
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Carter Snead, O., Nichols, A.C. & Liu, C.C. γ-Hydroxybutyric acid binding sites: Interaction with the GABA-benzodiazepine-picrotoxin receptor complex. Neurochem Res 17, 201–204 (1992). https://doi.org/10.1007/BF00966800

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