Abstract
γ-Hydroxybutyrate uptake by rat brain striatal slices was studied. The uptake was saturable with aK m of 702±107.10−6M. γ-Hydroxybutyrate uptake was sodium dependent and inhibited by the omission of potassium. In addition, the effect of ouabain suggests that the transport is dependent on a cation gradient. Several analogues of γ-hydroxybutyrate inhibit the transport system. GABA has no significant effect. This energy and cation dependent transport system is in favor of a transmitter or modulator role of γ-hydroxybutyrate in the rat brain striatum.
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Hechler, V., Bourguignon, J.J., Wermuth, C.G. et al. γ-Hydroxybutyrate uptake by rat brain striatal slices. Neurochem Res 10, 387–396 (1985). https://doi.org/10.1007/BF00964607
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DOI: https://doi.org/10.1007/BF00964607