Abstract
The ATP-sensitive potassium channel (KATP) has been shown to serve an endogenous cardioprotective role in a number of experimental models of myocardial stunning and infarction. More importantly, a majority of evidence has also been obtained which suggests that the KATP channel may be intimately involved in both triggering and maintaining the cardioprotection afforded by the phenomenon of ischemic preconditioning particularly in large animal models such as dogs and pigs. Although the evidence for an involvement of KATP in ischemic pre-conditioning is equivocal in smaller animal species such as rabbits and rats, activation of this channel by KATP channel openers produces cardioprotection in all species studied. Whether this channel is an important mediator of ischemic preconditioning in all animal species including man and the mechanism by which this cardio-protective effect is obtained await further experimental studies. Nevertheless, the use of selective potassium channel openers to mimic preconditioning in selected clinical settings may be a desirable future therapeutic goal.
This is a preview of subscription content, log in via an institution to check access.
References
Ashford MLJ, Bond CT, Blair TA, Adelman JP (1994) Cloning and functional expression of a rat heart KATP channel. Nature 370: 456–459
Auchampach JA, Grover GJ, Gross GJ (1992) Blockade of ischemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate. Cardiovas Res 26: 1054–1062
Gross GJ, Auchampach JA (1992) Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 70: 223–233
Grover GJ, Sleph PG, Dzwonczyk S (1992) Role of myocardial ATP-sensitive potassium channels in mediating preconditioning in the dog heart and their possible interaction with A1-receptors. Circulation 86: 1310–1316
Haessler R, Kuzume K, Chien GL, Wolff RA, Davis RF, Van Winkle DM (1994) Anaesthetics alter the magnitude of infarct limitation by ischaemic preconditioning. Cardiovasc Res 28: 1574–1580
Kingma Jr JG, Hazenberg M, Simard D, Rouleau JR (1994) Interactions between adenosine and ATP-sensitive potassium channels during ischemic preconditioning. J Mol Cell Cardiol 26: 6 (abstract)
Kitakaze M, Kamamura K, Chujo M, Mori H, Hori M (1994) Role of ectosolic 5′ nucldotidase activation in the infarct size-limiting effect mediated by the opening of K+ channels: implication for ischemic preconditioning. Circulation 90: 574 (abstract)
Liu GS, Thornton J, Van Winkle DM, Stanley AWH, Olsson RA, Downey JM (1991) Protection against infarction afforded by preconditioning is mediated via A1 adenosine receptors in rabbit heart. Circulation 84: 350–356
Liu Y, Downey JM (1992) Ischemic preconditioning protects against infarction in rat hearts. Am J Physiol 263: H1107–H1112
Liu Y, Ytrehus K, Downey JM (1994) Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium. J Mol Cell Cardiol 26: 661–668
Mizumura T, Nithipatikom K, Gross GJ (1995) Effects of nicorandil and nitroglycerin on infarct size, adenosine release and neutrophil infiltration in dogs. Cardiovasc Res (In Press)
Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a dely of lethal cell injury in ischemic myocardium. Circulation 74: 1124–1136
Parratt JR, Kane KA (1994) KATP channels in ischaemic preconditioning. Cardiovasc Res 28: 783–787
Quian YZ, Levasseur J, Yoshida JK, Jesse RL, Hess ML, Kukreja RC (1994) Acetylcholine partially preconditions rat hearts by glibenclamide sensitive mechanism. FASEB J 8: 747 (abstract)
Richard V, Blanc T, Tron C, Thuillez C (1994) Acetylcholine limits infarct size through muscarinic receptor stimulation and production of nitric oxide but does not contribute to preconditioning in rats. Circulation 90: 577 (abstract)
Rohmann SM, Weygandt H, Schelling P, Lues I (1992) ATP-sensitive potassium channel (KATP) opener bimakalim mimics preconditioning in swine. Circulation 86: I-555 (abstract)
Schulz R, Rose J, Heusch G (1994) Involvement of activation of ATP-dependent potassium channels in ischemic preconditioning in swine. Am J Physiol 267: H1341–H1352
Thornton JD, Thornton CS, Sterling DL, Downey JM (1993) Blockade of ATP-sensitive potassium channels increases infarct size but does not prevent preconditioning in rabbit hearts. Circ Res 72: 44–49
Tomai F, Crea F, Caspardone A, Versaci F, DePaulis R, Penta de Peppo A, Chiariello L, Gioffre' PA (1994) Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker. Circulation 90: 700–705
Toombs CF, Moore TL, Shebuski RJ (1993) Limitation of infarct size in the rabbit by ischaemic preconditioning is reversible with glibenclamide. Cardiovasc Res 27: 617–622
Toombs CF, McGee DS, Johnston WE, Vinten-Johansen J (1993) Protection from ischaemic-reperfusion injury with adenosine pretreatment is reversed by inhibition of ATP-sensitive potassium channels. Cardiovasc Res 27: 623–629
Wall T, Sheehy R, Hartman JC (1994) Role of bradykinin in myocardial preconditioning. J Pharmacol Exp Ther 270: 681–689, 1994
Yao Z, Gross GJ (1993) Acetylcholine mimics ischemic preconditioning via a glibenclamide-sensitive mechanism. Am J Physiol 264: H2221–H2225
Yao Z, Mizumura T, Mei DA, Gross GJ (1994) Activation of KATP channels may play a role in the “memory” of ischemic preconditioning in anesthetized dogs. Circulation 90: 573 (abstract)
Yao Z, Gross GJ (1994) The ATP-dependent potassium channel: an endogenous cardioprotective mechanism. J Cardiovasc Pharmacol 24: S28-S34
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gross, G.J. ATP-sensitive potassium channels and myocardial preconditioning. Basic Res Cardiol 90, 85–88 (1995). https://doi.org/10.1007/BF00789438
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00789438