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Salvage chemotherapy of refractory non-Hodgkin's lymphoma with aclacinomycin, behenoyl ara-C, etoposide, and prednisolone

  • Aclacinomycin Combination Therapy, Refractory Non-Hodgkin's Lymphoma
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Summary

A total of 40 patients with recurrent non-Hodgkin's lymphoma were treated with ABEP combination chemotherapy (aclarubicin,N 4-behenoyl-1-β-d-arabinofuranosylcytosine, etoposide, and prednisolone). A complete remission (CR) was achieved in 37.5% of the patients and partial remission, in 15.0%. The ABEP regimen proved to be effective in T-cell as well as B-cell lymphoma. It appears that the ABEP regimen may be partially non-cross-resistant with front-line doxorubicin-containing combinations. Survival for 39 months was achieved in 42.0% of the CR responders compared with 6.7% of partial responders (PRs) and nonresponders (NRs) (P<0.01). Diesease-free survival for 45 months was seen in 66% of the CR patients. The ABEP regimen was effective in the treatment of patients with recurrent or refractory lymphoma, enabling hope for long-term survival in the majority of CR cases.

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Authors and Affiliations

  1. The Third Department of Internal Medicine, Kanazawa University School of Medicine, 13-1 Takaramachi, 920, Kanazawa, Japan

    Takashi Yoshida, Shinobu Nakamura, Shigeki Ohtake, Kazumi Kobayashi, Masatoshi Kanno & Tamotsu Matsuda

  2. Wakamatsu National Hospital, Wakamatsu, Japan

    Sadaya Matano & Kunio Kondo

  3. Fukui Saiseikai Hospital, Fukui, Japan

    Kazuhiro Okafuji

  4. Tonami General Hospital, Tonami, Japan

    Masanobu Kanai & Rippo Sugimoto

  5. The First Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan

    Koichiro Egami & Hideyo Natori

Authors
  1. Takashi Yoshida
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  2. Shinobu Nakamura
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  3. Shigeki Ohtake
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  4. Kazumi Kobayashi
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  5. Masatoshi Kanno
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  6. Tamotsu Matsuda
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  7. Sadaya Matano
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  8. Kunio Kondo
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  9. Kazuhiro Okafuji
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  10. Masanobu Kanai
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  11. Rippo Sugimoto
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  12. Koichiro Egami
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  13. Hideyo Natori
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Yoshida, T., Nakamura, S., Ohtake, S. et al. Salvage chemotherapy of refractory non-Hodgkin's lymphoma with aclacinomycin, behenoyl ara-C, etoposide, and prednisolone. Cancer Chemother. Pharmacol. 25, 135–138 (1989). https://doi.org/10.1007/BF00692354

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  • DOI: https://doi.org/10.1007/BF00692354

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