Summary
Recent evidence suggests that the induction of bronchoconstriction in aspirin-sensitive patients by analgesics is due to the inhibiton of PG biosynthesis in their respiratory tract. PGEs might play the main defensive role in the bronchi of aspirin-sensitive asthmatics. Removal of this potent bronchodilator by PG synthetase inhibitors leaves the effects of spasmogens unopposed, and possibly promotes the release of histamine from its stores.
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References
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Szczeklik, A., Gryglewski, R.J. & Czerniawska-Mysik, G. Participation of prostaglandins in pathogenesis of aspirin-sensitive asthma. Naunyn-Schmiedeberg's Arch. Pharmacol. 297 (Suppl 1), S99–S101 (1977). https://doi.org/10.1007/BF00587792
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DOI: https://doi.org/10.1007/BF00587792