Summary
A double-blind cross-over comparison of a newβ 2-sympathomimetic bronchodilator, clenbuterol, with salbutamol and placebo has been made during a 24 day period of out-patient treatment of 19 adults with moderately severe asthma. Oral clenbuterol (10 µg 3 times a day) and salbutamol (4 mg 3 times a day) were equally and significantly (p<0.001) more effective than placebo, when daily records of peak expiratory flow or use of isoprenaline inhalations were the criteria of activity. Daily records of symptoms according to a questionnaire also suggested relief of the subjective effects of asthma during treatment with both active drugs (p<0.01).
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Salorinne, Y., Stenius, B., Tukiainen, P. et al. Double-blind cross-over comparison of clenbuterol and salbutamol tablets in asthmatic out-patients. Eur J Clin Pharmacol 8, 189–195 (1975). https://doi.org/10.1007/BF00567113
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DOI: https://doi.org/10.1007/BF00567113