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Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers

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Summary

The pharmacokinetics of tranexamic acid has been investigated in two healthy volunteers. The behaviour of the drug can be described in terms of a two compartment open model; the disposition (biological) half-life was 2.7 h and 1.9 h, respectively. In five normal volunteers the mean total recovery in urine 48 h after dosing was 94.8%. The renal clearance in the two subjects, adjusted to 1.73 m2 body surface area, was 135 and 132 ml/min/1.73 m2, respectively, indicating that tranexamic acid is eliminated by glomerular filtration and that neither tubular excretion nor absorption takes place.

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Eriksson, O., Kjellman, H., Pilbrant, Å. et al. Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers. Eur J Clin Pharmacol 7, 375–380 (1974). https://doi.org/10.1007/BF00558210

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  • DOI: https://doi.org/10.1007/BF00558210

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