Summary
An adenoma in the antropyloric mucosa of a patient with recurrent duodenal ulcers was identified by immunofluorescence as a gastrinoma. Resected pancreatic tissue showed greatly increased numbers of islets and ducts. Insulin and glucagon cells were revealed by immunofluorescence not only in the islets but also in the duct epithelium. Signs suggesting neoformation of islets from the duct epithelium were observed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ballard, H. S., Frame, B., Hartsock, R.: Familial multiple endocrine adenoma-peptic ulcer complex. Medicine (Baltimore) 43, 481–516 (1964)
Bloodworth, J. M. B., Elliott, D. W.: The histochemistry of pancreatic islet cell lesions. J. Amer. med. Ass. 183, 1011–1015 (1963)
Creutzfeldt, W., Arnold, R., Creutzfeldt, C., Feurle, G., Ketterer, H.: Gastrin and G-cells in the antral mucosa of patients with pernicious anemia, acromegaly and hyperparathyroidism and in a Zollinger-Ellison tumour of the pancreas. Europ. J. clin. Invest. 1, 461–479 (1971)
Creutzfeldt, W., Creutzfeldt, C., Perings, E.: Light and electron microscopic findings in three clinical cases of the Zollinger-Ellison syndrome. In: Non-insulin producing tumours of the pancreas (L. Demling and R. Ottenjann, eds.) p. 86–89. Stuttgart: Thieme 1969
Greider, M. H., McGuigan, J. E.: Cellular localization of gastrin in the human pancreas. Diabetes 20, 389–396 (1971)
Grimelius, L.: A silver nitrate stain for α2 cells in human pancreatic islets. Acta Soc. Med. upsalien. 73, 243–270 (1968)
Guida, P. M., Todd, J. E., Moore, S. W., Beal, J. M.: Zollinger-Ellison syndrome with interesting variations. Amer. J. Surg. 112, 807–817 (1966)
Hellerström, C., Hellman, B.: Some aspects of silver impregnation of the islets of Langerhans in the rat. Acta endocr. (Kbh.) 35, 518–532 (1960)
Holst, J. J., Aasted, B.: In preparation (1973)
Jennings, B. M.: Aldehyde-fuchsin staining applied to frozen sections for demonstrating pituitary and pancreatic beta cells. J. Histochem. Cytochem 13, 328–333 (1965)
Lomsky, R., Langr, F., Vortel, V.: Immunohistochemical demonstration of gastrin in mammalian islets of Langerhans. Nature (Lond.) 223, 618–619 (1969)
McGuigan, J. E., Greider, M. H.: Correlative immunochemical and light microscopic studies of the gastrin cell of the antral mucosa. Gastroenterology 60, 223–236 (1971a)
McGuigan, J. E., Greider, M. H.: On the gastrin cell. Gastroenterology 61, 795–796 (1971b)
McGuigan, J. E., Greider, M. H., Grawe, L.: Staining characteristics of the gastrin cell. Gastroenterology 62, 959–969 (1972)
Mitschke, H.: Vergleichende immunhistologische und cytochemische Untersuchungen der Gastrinzellen beim Menschen. Virchows Arch. Abt. A 353, 347–359 (1971)
Mitschke, H., Becker, M.: Zur Cytopathologie der disseminierter endokrinen Zellen des Magens bei Gastritis, Ulcus und Magencarcinom. Virchows Arch. Abt. A 358, 81–98 (1973)
Pearse, A. G. E., Bussolati, G.: The identification of gastrin cells as G cells. Virchows Arch. Abt. A 355, 99–104 (1972)
Polak, J. M., Stagg, B., Pearse, A. G. E.: Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states. Gut 13, 501–512 (1972)
Puchtler, H., Sweat, F., Levine, M.: On the binding of Congo red by amyloid. J. Histochem. Cytochem. 10, 355–364 (1962)
Rehfeld, J., Stadil, F., Rubin, B.: Production and evaluation of antibodies for the radioimmunoassay of gastrin. Scand. J. clin. Lab. Invest. 30, 221–232 (1972)
Robb, P.: The development of the islets of Langerhans in the human foetus. Quart. J. exp. Physiol. 46, 335–343 (1961)
Royston, C. M. S., Brew, D. St. J., Garnham, J. R., Stagg, B. H., Polak, J.: The Zollinger-Ellison syndrome due to an infiltrating tumour of the stomach. Gut 13, 638–642 (1972)
Singh, I.: A modification of the Masson-Hamperl method for staining of argentaffin cells. Anat. Anz. 115, 81–82 (1964)
Solcia, E.: The gastrin cell and the secretin cell. Rendic. R. Gastroenterol. 4, 22–30 (1972)
Solcia, E., Capella, C., Vassallo, G.: Lead-haematoxylin as a stain for endocrine cells. Histochemie 20, 116–126 (1969a)
Solcia, E., Capella, C., Vassallo, G.: Endocrine cells of the stomach and pancreas in states of gastric hypersecretion. Rendic. R. Gastroenterol. 2, 147–158 (1970)
Solcia, E., Capella, C. Vassallo, G.: On the staining of the gastrin cell. Gastroenterology 61, 794–795 (1971)
Solcia, E., Vassallo, G., Capella, C.: Selective staining of endocrine cells by basic dyes after acid hydrolysis. Stain Technol. 43, 257–263 (1968)
Solcia, E., Vassallo, G., Capella, C.: Studies on the G cells of the pyloric mucosa, the probable site of gastrin secretion. Gut 10, 379–388 (1969b)
Vance, J. E., Stoll, R. W., Kitabchi, A. E., Buchanan, K. D., Hollander, D., Williams, R. H.: Familial nesidioblastosis as the predominant manifestation of multiple endocrine adenomatosis. Amer. J. Med. 52, 211–227 (1972)
Vassallo, G., Solcia, E., Bussolati, G., Polak, J. M., Pearse, A. G. E.: Non-G cell-producing tumours of the pancreas. Virchows Arch. Abt. B 11, 66–79 (1972)
Weichert, R., Reed, R., Creech, O.: Carcinoid-islet cell tumours of the duodenum. Ann. Surg. 165, 660–669 (1967)
Weichert, R., Roth, L. M., Harkin, J. C.: Carcinoid-islet cell tumour of the duodenum and associated multiple carcinoid tumours of the ileum. An electron microscopic study. Cancer (Philad.) 27, 910–918 (1971)
Yang, Y. H., Hunter, W. C.: The relation of the pancreatic ducts to the islets of Langerhans. Arch. Path. 67, 505–514 (1959)
Zollinger, R. M., Ellison, E. H.: Primary peptic ulcerations of the jejunum associated with islet cell tumours of the pancreas. Ann. Surg. 142, 709–728 (1955)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Larsson, L.I., Ljungberg, O., Sundler, F. et al. Antro-pyloric gastrinoma associated with pancreatic nesidioblastosis and proliferation of islets. Virchows Arch. Abt. A Path. Anat. 360, 305–314 (1973). https://doi.org/10.1007/BF00548351
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00548351