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Sympathomimetic inhibition of noradrenaline release: Mediated by prostaglandins?

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Summary

In isolated perfused rabbit hearts, the effec of oxymetazoline and phentolamine on the stimulation-induced overflow of noradrenaline was tested after the synthesis of prostaglandins had been blocked by indomethacin. Indomethacin changed neither the decrease of overflow caused by oxymetazoline nor the increase caused by phentolamine. It is concluded that prostaglandins are not involved to any major degree in the modulation of noradrenaline release by drugs with affinity to α-receptors, or in the feed-back inhibition of transmitter release mediated by the effect of liberated noradrenaline on α-receptive sites.

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Authors and Affiliations

  1. Pharmakologisches Institut, Klinikum der Universität Essen, Germany

    K. Starke & H. Montel

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  1. K. Starke
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  2. H. Montel
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Starke, K., Montel, H. Sympathomimetic inhibition of noradrenaline release: Mediated by prostaglandins?. Naunyn-Schmiedeberg's Arch. Pharmacol. 278, 111–116 (1973). https://doi.org/10.1007/BF00501869

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  • DOI: https://doi.org/10.1007/BF00501869

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