Abstract
After several months of treatment, Cebus apella, Cebus albifrons, and Saimiri sciurea monkeys maintained on haloperidol, in doses of 0.5 or 1.0 mg/kg orally 5 days per week, began to display severe movement disorders, typically 1–6 h post-drug. Cebus monkeys exhibited violent, uncontrolled movements that flung the animals about the cage. Such episodes usually lasted only a few minutes, recurring several times during the period following drug ingestion. Writhing and bizarre postures dominated the response in S. sciurea. Cessation of drug treatment produced no distinctive after-effects. When tested as long as 508 days after the last administration, however, Cebus monkeys responded to haloperidol with several episodes of hyperkinesis, even at challenge doses considerably lower than those in the original treatment.
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Crane, G. E.: Clinical psychopharmacology in its 20th year. Science 181, 124–128 (1973)
Crane, G., Garner, R. Jr. (eds.): Psychotropic drugs and dysfunctions of the basal ganglia, a multidisciplinary workshop. Washington, D.C.: U. S. Government Printing Office 1969
Deneau, G. A., Crane, G. E.: Dyskinesia in rhesus monkeys tested with high doses of chlorpromazine. In: Psychotropic drugs and dysfunctions of the basal ganglia, a multidisciplinary workshop, G. E. Crane, R. Gardner Jr., eds., pp. 12–14. Washington, D.C.: U.S. Government Printing Office 1969
Deuel, R. K.: Neurological examination of rhesus monkeys treated with high doses of chlorpromazine. In: Psychotropic drugs and dysfunctions of the basal ganglia, a multidisciplinary workshop, G. E., Crane, R. Gardner, Jr., eds., pp. 15–18. Washington, D.C.: U.S. Government Printing Office 1969
DiMascio, A. Shader, R. S. (eds.): Butyrophenones in psychiatry. New York: Raven Press 1972
Eibergen, R. D., Carlson, K. R.: Dyskinesias in monkeys: Interaction of methamphetamine with prior methadone treatment. Pharmac. Biochem. Behav. 5, 175–187 (1976)
Freedman, D. X.: Neurological syndrome associated with antipsychotic drug use: A special editorial report. Arch. gen. Psychiat. 28, 463–467 (1973)
Garman, R. H., Weiss, B., Evans, H. L.: Alkylmercurial encephalopathy in the monkey. Acta Neuropathologica 32, 61–74 (1975)
Grabowski, S. W.: Haloperidol for control of severe emotional reactions in mentally retarded patients. Dis. nerv. Syst. 34, 315–317 (1973)
Gunne, L.-M., Bárány, S.: Haloperidol-induced tardive dyskinesia in monkeys. Psychopharmacology 50, 237–240 (1976)
Jacobson, G., Baldessarini, R. J., Manschreck, T.: Tardive and withdrawal dyskinesia associated with haloperidol. Amer. J. Psychiat. 131, 910–913 (1974)
Man, P. L.: Long-term effects of haloperidol. Dis. nerv. Syst. 34, 113–118 (1973)
Ordy, J. M., Samorajsky, T., Schroeder, D. M.: Haloperidol and electric shock interaction effects on tremors and on catecholamine concentrations in the caudate nucleus of the squirrel monkey. Brain Research 12, 427–436 (1969)
Paulson, G. W.: Dyskinesia in monkeys. In: Advances in neurology, vol. I, A. Barbeau, T. N. Chase, G. W. Paulson, eds., pp. 647–650. New York: Raven Press 1973
Sassin, J. F.: Drug-induced dyskinesia in monkeys. In: Advances in neurology, vol. 10, B. S. Meldrum and C. D. Marsden, eds., pp. 47–54. New York: Raven Press 1975
Shader, R. I.: Extrapyramidal and cardiovascular side effects of butyrophenones. In: Butyrophenones in psychiatry, A. DiMascio and R. I. Shader, eds., pp. 97–114 (Ch. 7). New York: Raven Press 1972
Weiss, B.: Long-term behavioral consequences of exposure to drugs and pollutants. In: Alcohol, drugs and brain damage, J. G. Rankin, ed., pp. 71–79. Toronto: Addiction Research Foundation of Ontario 1975
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Weiss, B., Santelli, S. & Lusink, G. Movement disorders induced in monkeys by chronic haloperidol treatment. Psychopharmacology 53, 289–293 (1977). https://doi.org/10.1007/BF00492366
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DOI: https://doi.org/10.1007/BF00492366