Skip to main content
Log in

Effects of dopamine uptake inhibitors on schedule-controlled behavior in the squirrel monkey

  • Short Reports
  • Published:
Psychopharmacology Aims and scope Submit manuscript

Abstract

Squirrel monkeys responded under a multiple fixedinterval (FI) fixed-ratio (FR) schedule of stimulus-shock termination. Benztropine mesylate (0.03–1.7 mg/kg), bupropion HCl (0.3–5.6 mg/kg), mazindol (0.01–0.3 mg/kg), and nomifensine maleate (0.1–1.0 mg/kg) markedly increased responding under the FI schedule, but not under the RR schedule. Mazindol was about three-times more potent than nomifensine and ten-times more potent than bupropion. Benztropine and mazindol were about equal in potency. The order and relative magnitude of potency differences for mazindol, nomifensine, and bupropion are similar to those reported by others for in vitro inhibition of dopamine uptake in rat striatum, but the relative potency of benztropine was greater in these behavioral experiments than expected from its potency in inhibiting dopamine uptake.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Coyle JT, Snyder SH (1969) Antiparkinsonian drugs: Inhibition of dopamine uptake in the corpus striatum as a possible mechanism of action. Science 166:899–901

    Google Scholar 

  • Dews PB, Wenger GR (1977) Rate-dependency of the behavioral effects of amphetamine. In: Thompson T, Dews PB (eds) Advances in behavioral pharmacology, vol 1. Academic, New York, pp 167–227

    Google Scholar 

  • Esplin DW (1970) Centrally acting muscle relaxants: Drugs for Parkinson's disease. In: Goodman LS, Gilman A (eds) The pharmacological basis of therapeutics. Macmillan, New York, pp 226–236

    Google Scholar 

  • Ferris RM, White HL, Cooper BR, Maxwell RA, Tang FLM, Beaman OJ, Russell A (1981) Some neurochemical properties of a new antidepressant, bupropion hydrochloride (Wellbutrin). Drug Dev Res 1:21–35

    Google Scholar 

  • Heikkila RE, Babington RG, Houlihan WJ (1981) Pharmacological studies with several analogs of mazindol: Correlation between effects on dopamine uptake and various in vivo responses. Eur J Pharmacol 71:277–286

    Google Scholar 

  • Hoffmann I (1973) 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline, a new antidepressant. Arzneim Forsch 23:45–50

    Google Scholar 

  • Katz RJ, Baldrighi G, Carroll BJ (1977) Eflects of nomifensine (HOE 984) upon psychomotor activity and intracranial self-stimulation in the rat. Pharmacol Biochem Behav 7:269–272

    Google Scholar 

  • Koe BK (1976) Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain. J Pharmacol Exp Ther 199:649–661

    Google Scholar 

  • McKearney JW (1981) Individual differences in effects of tricyclic antidepressants and anticholinergic drugs on operant behavior in the squirrel monkey. Life Sci 28:2049–2054

    Google Scholar 

  • McKearney JW (1982a) Stimulant, actions of histamine-H1 antagonists on operant behavior in the squirrel monkey. Psychopharmacology 77:156–158

    Google Scholar 

  • McKearney JW (1982b) Effects of tricyclic antidepressant and anticholinergic drugs on fixed-interval responding in the squirrel monkey. J Pharmacol Exp Ther 222:215–219

    Google Scholar 

  • McMillen BA, German DC, Shore PA (1980) Functional and pharmacological significance of brain dopamine and norepinephrine storage pools. Biochem Pharmacol 29:3045–3050

    Google Scholar 

  • Richelson E (1981) Tricyclic antidepressants: interactions with histamine and muscarinic acetylcholine receptors. In: Enna SJ, Malick JB, Richelson E (eds) Antidepressants: Neurochemical, behavioral, and clinical perspectives. Raven, New York, pp 53–73

    Google Scholar 

  • Ross SB (1979) The central stimulatory action of inhibitors of the dopamine uptake. Life Sci 24:159–168

    Google Scholar 

  • Spyraki C, Fibiger HC (1981) Intravenous self-administration of nomifensine in rats: Implications for abuse potential in humans Science 212:1167–1168

    Google Scholar 

  • Wilson MC, Schuster CR (1976) Mazindol self-administration in the rhesus monkey. Pharmacol Biochem Behav 4:207–210

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

McKearney, J.W. Effects of dopamine uptake inhibitors on schedule-controlled behavior in the squirrel monkey. Psychopharmacology 78, 377–379 (1982). https://doi.org/10.1007/BF00433746

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00433746

Key words

Navigation