Abstract
Parenteral administration of the adenosine deaminase (ADA) inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) results in a profound decrease in spontaneous motor activity in mice and rats. The inhibition of cortical ADA activity measured ex vivo parallels the decrease in spontaneous motor activity in a time-dependent manner. Nonetheless, a marked reduction in electroencephalographically defined sleep was observed in rats during a period when both spontaneous motor activity and ADA activity were profoundly inhibited. These data suggest that EHNA produces in rats a state of ‘quiescent waking’, which may be related to the observed inhibition of brain ADA activity.
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Mendelson, W.B., Kuruvilla, A., Watlington, T. et al. Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): Relationship to inhibition of brain adenosine deaminase. Psychopharmacology 79, 126–129 (1983). https://doi.org/10.1007/BF00427798
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DOI: https://doi.org/10.1007/BF00427798