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Haloperidol-induced tardive dyskinesia in monkeys

  • Animal Studies
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Abstract

In three cebus monkeys the chronic daily administration of haloperidol (0.5 mg/kg/day orally) created sedation and parkinsonism during the first 5–7 weeks. Later the animals developed signs reminiscent of acute dystonia, as seen in the clinic during treatment with neuroleptics. These signs were dose-dependent and in extreme cases included widespread tonic and clonic seizures. After 3 and 12 months, respectively, two of the cebus monkeys developed buccolingual signs (grimacing and tongue protrusion), similar to tardive dyskinesia in the clinic.

The tardive dyskinesia symptoms were reduced in a dose-dependent manner after each haloperidol administration, being most pronounced in the morning before haloperidol was given. Biperiden reduced acute dystonia but reinstated signs of tardive dyskinesia, which had been abolished by haloperidol. It is suggested that cebus monkeys may provide a useful animal model for the study of neurologic long-term complications from neuroleptic drugs.

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References

  • Ayd, F. J.: Persistent dyskinesia: a neurologic complication of major tranquilizers. Med. Sci. 18, 32–40 (1967)

    Google Scholar 

  • Bédard, P., LaRochelle, L., De Léan, J., Lafleur, J.: Dyskinesias induced by long term administration of haloperidol in the monkey. Physiologist 15, 83 (1972)

    Google Scholar 

  • Crane, G. E.: Persistent dyskinesia. Brit. J. Psychiat. 122, 395–405 (1973)

    Google Scholar 

  • Deneau, G. A., Crane, G. E.: Dyskinesia in rhesus monkeys tested with high doses of chlorpromazine. In: Psychotropic drugs and dysfunctions of the basal ganglia, G. E. Crane and J. R. Gardner, eds., pp. 12–24. U.S. Publ. Health Service, Publ. No. 1938, (1969)

  • Marsden, C. D., Tarsy, D., Baldessarini, R. J.: Spontaneous and drug-induced movement disorders in psychotic patients. In: Psychiatric aspects of neurological disease, D. F. Benson and D. Blumer, eds., pp. 219–266. New York: Grune & Stratton 1975

    Google Scholar 

  • Messiha, F. S.: The relationship of dopamine excretion to chlorpromazine-induced dyskinesia in monkeys. Arch. int. Pharmacodyn. 209, 5–9 (1974)

    Google Scholar 

  • Messiha, F. S.: A study of biogenic amine metabolites in the cerebrospinal fluid and urine of monkeys with chlorpromazine-induced dyskinesia. J. neurol. Sci. 21, 39–46 (1974)

    Google Scholar 

  • Paulson, G. W.: Dyskinesias in monkeys. Advances in neurology, A. Barbeau, T. N. Chase, and G. W. Paulson, eds., vol. 1, pp. 647–650. New York: Raven Press 1973

    Google Scholar 

  • Sassin, J. F.: Drug-induced dyskinesia in monkeys. Advances in neurology, B. S. Meldrum and C. D. Marsden, eds., vol. 10, pp. 47–54. New York: Raven Press 1975

    Google Scholar 

  • Weiss, B.: Long-term behavioural consequences of exposure to drugs and pollutants. In: Alcohol, drugs and brain damage, J. G. Rankin, ed., pp. 71–79. Toronto: Addiction Research Foundation of Ontario 1975a

    Google Scholar 

  • Weiss, B.: Episodic hyperkinesia in monkeys following chronic haloperidol. Neuroscience abstracts, vol. 1, p. 238. 5th Annual Meeting of the Society for Neuroscience, New York 1975b

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Gunne, LM., Bárány, S. Haloperidol-induced tardive dyskinesia in monkeys. Psychopharmacology 50, 237–240 (1976). https://doi.org/10.1007/BF00426838

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  • DOI: https://doi.org/10.1007/BF00426838

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