Abstract
Intravenous THC, 30–44.8 μg/kg, was administered to four subjects. Each received THC on four occasions preceded by either i.v. saline, 0.04 mg/kg atropine sulfate, 0.2 mg/kg propranolol, or both drugs together. Heart rates, subjective intoxication and symptom ratings, time productions, and EEG activity were measured. In the absence of autonomic blocking drugs, THC produced characteristic tachycardia, subjective intoxication, and EEG effects. After combined autonomic blockade, THC had no effect on heart rate, while subjective and EEG changes remained as intense. These findings argue against the hypothesis that the subjective and EEG effects of THC are mediated by autonomic receptors or by interoception of peripheral autonomic actions of THC.
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References
Beaconsfield, P., Ginsburg, J., Rainsbury, R.: Marijuana smoking: cardiovascular effects in man and possible mechanisms. N. Engl. J. Med. 287, 209–212 (1972)
Benowitz, N., Rosenberg, J., Rogers, W., Bachman, J., Jones, R.: Cardiovascular effects of intravenous delta-9-THC: autonomic nervous mechanism. Clin. Pharmacol. Ther. (in press, 1979)
Drew, W., Miller, L.: Cannabis: neural mechanisms and behavior — a theoretical review. Pharmacology 11, 11–32 (1974)
Drew, W., Kipplinger, G., Miller, L., Marx, M.: Effects of propranolol on marijuana-induced cognitive dysfunctioning. Clin. Pharmacol. Ther. 13, 526–533 (1972)
Jones, R., Benowitz, N., Bachman, J.: Clinical studies of cannabis tolerance and dependence. Ann. N.Y. Acad. Sci. 282, 221–239 (1976)
Jose, A., Taylor, R.: Autonomic blockade by propranolol and atropine to study intrinsic myocardial function in man. J. Clin. Invest. 48, 2019–2031 (1969)
Martz, R., Brown, D., Forney, R., Bright, T., Kiplinger, G., Rodda, B.: Propranolol antagonism of marijuana induced tachycardia. Life Sci. 11, 999–1005 (1972)
Miller, L., Cornett, T., Drew, W., McFarland, D., Brightwell, D., Wikler, A.: Marijuana: dose-response effects on pulse rate, subjective estimates of potency, pleasantness and recognition memory. Pharmacology 15, 268–275 (1977)
Peters, B., Lewis, E., Dustman, R., Straight, R., Beck, E.: Sensory, perceptual, motor and cognitive functioning and subjective reports following oral administration of delta-9-tetrahydrocannabinol. Psychopharmacology 47, 141–148 (1976)
Sulkowski, A., Vachon, L., Rich, E.: Propranolol effects on acute marijuana intoxication in man. Psychopharmacology 52, 47–53 (1977)
Tinklenberg, J., Roth, W., Kopell, B.: Marijuana and ethanol: Differential effects on time perception, heart rate and subjective response. Psychopharmacology 48, 275–279 (1976)
Volavka, J., Crown, P., Dornbush, R., Feldstein, S., Fink, M.: EEG, heart rate and mood change (‘high’) after cannabis. Psychopharmacologia (Berl.) 32, 11–25 (1973)
Volavka, J., Fink, M., Panayiotopoulos, C.: Acute EEG effects of cannabis preparations in long-term hashish users. In: Hashish: studies of long-term use, C. Stefanis, R. Dornbush, M. Fink, eds., pp. 79–89. New York: Raven Press 1977
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Bachman, J.A., Benowitz, N.L., Herning, R.I. et al. Dissociation of autonomic and cognitive effects of THC in man. Psychopharmacology 61, 171–175 (1979). https://doi.org/10.1007/BF00426733
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DOI: https://doi.org/10.1007/BF00426733