Abstract
Apomorphine, d-amphetamine, methylphenidate, nomifensine, ET495 and amantadine each induced a dose-dependent stereotyped behaviour in the rat. l-Dopa was inactive in the absence of any pretreatment. The behaviour induced by apomorphine, methylphenidate, nomifensine and amantadine persisted following pretreatment with α-methylparatyrosine. However, only the effect of apomorphine developed following combined pretreatment with reserpine/ α-methylparatyrosine. The effects of all Stereotypic agents were inhibited by haloperidol, apomorphine, methylphenidate and nomifensine being most resistant.
All agents, including l-Dopa, induced a dose-dependent contralateral circling behaviour in animals with asymmetric lesion of the medial raphé nucleus and a dose-dependent ipsilateral circling after unilateral lesion of the substantia nigra. Following unilateral lesions in the ventromedial area of the medial forebrain bundle (medial to the substantia nigra and carrying 5-hydroxytryptamine neurones) amphetamine caused an ipsilateral circling behaviour, amantadine a behaviour which was characterised by definite bursts in either direction, and all other agents caused contralateral circling.
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Costall, B., Naylor, R.J. A comparison of circling models for the detection of antiparkinson activity. Psychopharmacologia 41, 57–64 (1975). https://doi.org/10.1007/BF00421307
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DOI: https://doi.org/10.1007/BF00421307