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Augmentation of the behavioral effects of amphetamine by scopolamine

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Summary

Non-effective doses of scopolamine were found to augment the tendency of amphetamine to increase the response rates of rats working in an operant, shock-avoidance situation. This finding is presumably related to our earlier observation that the related parasympatholytic, atropine, also had this augmenting action.

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References

  • Carlton, P. L., and P. Didamo: Augmentation of the behavioral effects of amphet-amine by atropine. J. Pharmacol. exp. Ther. 132, 91–96 (1961).

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  • Sidman, M.: Avoidance conditioning with brief shock and no exteroceptive warning signal. Science 118, 157–158 (1953).

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Authors and Affiliations

  1. The Squibb Institute for Medical Research, New Brunswick, New Jersey, USA

    Peter L. Carlton (Senior Research Scientist)

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  1. Peter L. Carlton
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Carlton, P.L. Augmentation of the behavioral effects of amphetamine by scopolamine. Psychopharmacologia 2, 377–380 (1961). https://doi.org/10.1007/BF00404125

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  • DOI: https://doi.org/10.1007/BF00404125

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