Summary
A GC-MS method is described for the determination of thiodiglycolic acid in 1 ml-samples of urine. The variation coefficient for a series of four determinations was 2.7%. To investigate the variation between values determined on different days, four samples were analysed over periods of 4–8 days. The mean variation coefficient of this series was 6.4 ± 1.3%. From 34 different human urine specimen from males aged between 20 and 55 years, an average level of 0.64 ± 0.32μg/ml was determined. From 14 females aged between 19 and 42 years, the corresponding values were 0.51 ± 0.20μg/ml.
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Abbreviations
- TdGA:
-
Thiodiglycolic acid (also known as dicarboxymethyl sulphide or thiodiacetic acid)
- VCM:
-
Vinyl chloride monomer
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Müller, G., Norpoth, K. & Wickramasinghe, R.H. An analytical method, using GC-MS, for the quantitative determination of urinary thiodiglycolic acid. Int. Arch Occup Environ Heath 44, 185–191 (1979). https://doi.org/10.1007/BF00381133
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DOI: https://doi.org/10.1007/BF00381133