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Improved therapy of myotonia with the lidocaine derivative tocainide

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Summary

The antimyotonic effect of the antiarrhythmic drug tocainide was tested in 14 patients. With 1200 to 1600 mg/d all patients reported good improvement. This was substantiated by objective tests. Only four patients noticed minor side effects.

Zusammenfassung

Die antimyotone Wirkung des Antiarrhythmikums Tocainid wurde an 14 myotonen Patienten untersucht. Bei Tagesdosen von 1200–1600 mg berichteten alle Patienten über gute Unterdrückung der Myotonie; dies wurde durch objektive Tests bestätigt. Nur 4 Patienten berichteten geringfügige Nebeneffekte.

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References

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Authors and Affiliations

  1. Abteilung für Allgemeine Physiologie der Universität Ulm, Oberer Eselsberg, D-7900, Ulm, Federal Republic of Germany

    R. Rüdel

  2. Neurologische Klinik der Technischen Universität München, Möhlstraße 28, D-8000, München 80, Federal Republic of Germany

    R. Dengler

  3. Neurologische Universitätsklinik, Josef-Schneider-Straße 11, D-8700, Würzburg, Federal Republic of Germany

    K. Ricker & A. Haass

  4. Universitäts-Nervenklinik, D-6650, Homburg/Saar, Federal Republic of Germany

    W. Emser

Authors
  1. R. Rüdel
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  2. R. Dengler
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  3. K. Ricker
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  4. A. Haass
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  5. W. Emser
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Rüdel, R., Dengler, R., Ricker, K. et al. Improved therapy of myotonia with the lidocaine derivative tocainide. J Neurol 222, 275–278 (1980). https://doi.org/10.1007/BF00313157

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  • DOI: https://doi.org/10.1007/BF00313157

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