Summary
High glutathione transferase activity towards trans-stilbene oxide has been observed in resting mononuclear leukocytes only in a portion of the individuals examined. Approximately 46% of a population of 248 individuals demonstrated this high activity. In addition, eight families have been investigated in order to elucidate the hereditary transmission of this activity. The results are consistent with a dominant expression of a single gene located on an autosomal chromosome for this high glutathione transferase activity.
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References
Awasthi YC, Dao DD, Saneto RP (1980) Interrelationship between anionic forms of glutathione S-transferases of human liver. Biochem J 191:1–10
Board PG (1981) Biochemical genetics of glutathione S-transferase in man. Am J Hum Genet 33:36–43
Böyum A (1968) Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 21 [Suppl]:97
Gillham B (1971) The reaction of aralkyl sulfate esters with glutathione catalysed by rat liver preparations. Biochem J 121:667–672
Guthenberg C, Åkerfeldt K, Mannervik B (1979) Purification of glutathione S-transferase from human placenta. Acta Chem Scand [B] 33:595–596
Jakoby WB (1978) The glutathione S-transferases: a group of multifunctional detoxification proteins. Adv Enzymol 46:383–414
Jakoby WB, Habig WH (1980) Glutathione transferases. In: Jakoby WB (ed) Enzymatic basis of detoxication, vol 2. New York, Academic Press, pp 63–94
Kamisaka K, Habig WH, Ketley JH, Arias IM, Jakoby WB (1975) Multiple forms of human glutathione S-transferase and their affinity for bilirubin. Eur J Biochem 60:153–161
Kellermann G, Luyten-Kellermann M, Shaw CR (1973) Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes. Am J Hum Genet 25:327–331
Koskelo K, Valmet E (1980) Acid glutathione S-transferase from human liver: preliminary report. Scand J Clin Lab Invest 40:179–184
Koskelo K, Valmet E, Tenhunen R (1981) Purification and characterization of an acid glutathione S-transferase from human lung. Scand J Clin Lab Invest 41:683–689
Marcus CJ, Habig WH, Jakoby WB (1978) Glutathione transferase from human erythrocytes. Arch Biochem Biophys 199:287–293
Morgenstern R, DePierre JW (1983) Microsomal glutathione transferase: purification in unactivated form and further characterization of the activation process, substrate specificity and amino acid composition. Eur J Biochem 134:591–597
Seidegård J, DePierre JW, Birberg W, Pilotti Å, Pero RW (1984) Characterization of soluble glutathione transferase activity in resting mononuclear leukocytes from human blood. Biochem Pharmacol 19:3053–3058
Warholm M, Guthenberg C, Mannervik B, von Bahr C, Glaumann H (1980) Identification of a new glutathione S-transferase in human liver. Acta Chem Scand [B] 34:607–621
Warholm M, Guthenberg C, Mannervik B, von Bahr C (1981) Purification of a new glutathione S-transferase (transferase μ) from human liver having high activity with benzo(a)pyrene-4,5-oxide. Biochem Biophys Res Commun 98:512–519
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Seidegård, J., Pero, R.W. The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes. Hum Genet 69, 66–68 (1985). https://doi.org/10.1007/BF00295531
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DOI: https://doi.org/10.1007/BF00295531