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Increased sister chromatid exchanges in epileptic children during long-term therapy with phenytoin

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Summary

In lymphocyte cultures of nine children suffering from epilepsy and therefore treated with phenytoin (DPH), increased sister chromatid exchanges (SCE) were found. Their average SCE-rate exceeded that of a normal control group by 55%.

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References

  • Esser KJ, Kotlarek F, Habedank M, Mühler U, Mühler E (1981) Chromosomal investigations in epileptic children during long-term therapy with phenytoin or primidone. Hum Genet 56:345–348

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Authors and Affiliations

  1. Lehrgebiet Klinische Cytogenetik der Medizinischen Fakultät der RWTH Aachen, Goethestr. 27/29, D-5100, Aachen, Germany

    M. Habedank, K. -J. Eßer & C. Stumpf

  2. Abteilung Kinderheilkunde der Medizinischen Fakultät der RWTH Aachen, Goethestr. 27/29, D-5100, Aachen, Germany

    D. Brüll & F. Kotlarek

Authors
  1. M. Habedank
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  2. K. -J. Eßer
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  3. D. Brüll
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  4. F. Kotlarek
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  5. C. Stumpf
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Additional information

This work contains parts of the M.D. thesis of C. Stumpf

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Habedank, M., Eßer, K.J., Brüll, D. et al. Increased sister chromatid exchanges in epileptic children during long-term therapy with phenytoin. Hum Genet 61, 71–72 (1982). https://doi.org/10.1007/BF00291338

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  • DOI: https://doi.org/10.1007/BF00291338

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