The epidemiologic literature on the relationship between vegetable and fruit consumption and human cancer at a variety of sites is reviewed systematically. A total of 13 ecologic studies, nine cohort studies, and 115 case-control studies are included. Cancer of all sites, cancers of lung, breast, colon, rectum, esophagus, larynx, oral cavity and pharynx, stomach, pancreas, prostate, bladder, ovary, endometrium, cervix, and thyroid, as well as mesothelioma and gestational trophoblastic disease, are considered. Relevant data from clinical trials, animal, and in vitro studies are included. It is concluded that consumption of higher levels of vegetables and fruit is associated consistently, although not universally, with a reduced risk of cancer at most sites. The association is most marked for epithelial cancers-particularly those of the alimentary and respiratory tracts-and, currently, is weak to nonexistent for hormone-related cancers. The association exists for a wide variety of vegetables and fruit with some suggestion that raw forms are associated most consistently with lower risk. Possible mechanisms by which vegetable and fruit intake might alter risk of cancer and possible adverse effects of vegetable and fruit consumption will be considered in Part II of this review.
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References
Kohman EF. The chemical components of onion vapors responsible for wound-healing qualities. Science 1947; 106: 625–7.
Fenwick GR, Heaney RK, Mullen WJ. Glucosinolates and their breakdown products in foods and food plants. CRC Crit Rev Food Sci Nutr 1983; 18: 123–201.
Darby WJ, Ghalioungui P, Grivetti L. Food: The Gift of Osiris, Vol. 2. New York: Academic Press Inc., 1977.
Doll R, Peto R. The Causes of Cancer. New York: Oxford University Press, 1981: 1256.
Lanza E, Jones DY, Block G, Kessler L. Dietary fiber intake in the US population. Am J Clin Nutr 1987; 46: 790–7.
Pearl RC. Trends in consumption and processing of fruits and vegetables in the United States. Food Tech 1990; 44: 102–4.
Hormozdiari H, Day NE, Aramesh B, Manboubi E. Dietary factors and esophageal cancer in the Caspian Littoral of Iran. Cancer Res 1975; 35: 3493–8.
Malhotra SL. Dietary factors in a study of colon cancer from Cancer Registry, with special reference to the role of saliva, milk, and fermented milk products and vegetable fibre. Med Hypotheses 1977; 3: 122–6.
Bingham SA, Williams DDR, Cole TJ, James WPT. Dietary fibre and regional large-bowel cancer mortality in Britain. Br J Cancer 1979; 40: 456–63.
Bingham SA, Williams DDR, Cummings JH. Dietary fibre consumption in Britain; new estimates and their relation to large bowel cancer mortality. Br J Cancer 1985; 52: 399–402.
Nagai M, Hashimoto T, Yanagawa H, Yokoyama H, Minowa M. Relationship of diet to the incidence of esophageal and stomach cancer in Japan. Nutr Cancer 1982; 3: 257–68.
Correa P, Cuello C, Fajardo LF, Haenszel W, Bolanos O de Ramirez B. Diet and gastric cancer: nutrition survey in a high-risk area. JNCI 1983; 70: 673–8.
Rose DP, Boyar AP, Wynder EL. International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption. Cancer 1986; 58: 2363–71.
Ghadirian P. Food habits of the people of the Caspian Littoral of Iran in relation to esophageal cancer. Nutr Cancer 1987; 9: 147–57.
Jaskiewicz K, Marasa WF, Lazarus C, Beyers AD, Van Helden PD. Association of esophageal cytological abnormalities with vitamin and lipotrope deficiencies in populations at risk for esophageal cancer. Anticancer Res 1988; 8: 711–15.
Jaskiewicz K. Oesophageal carcinoma: cytopathology and nutritional aspects in aetiology. Anticancer Res 1989; 9: 1847–52.
Maruchi N, Aoki S, Tsuda K, Tanaka Y, Toyokawa H. Relation of food comsumption to mortality in Japan, with special reference to international figures. Gann 1977; 68: 1–13.
McKoewn-Eyssen GE, Bright-See E. Dietary factors in colon cancer: international relationships. Nutr Cancer 1984; 6: 160–70.
Jedrychowski WA, Popiela T. Gastric cancer in Poland—a decreased malignancy due to changing nutritional habits of the population. Neoplasma 1986; 33: 97–106.
Takasaki Y, Pieddeloup C, Anzai S. Trends in food intake and digestive cancer mortalities in Japan. Hum Biol 1987; 59: 951–7.
Kväle G, Bjelke E, Gart JJ. Dietary habits and lung cancer risk. Int J Cancer 1983; 31: 397–405.
Colditz GA, Branch LG, Lipnick RJ. Increased green and vellow vegetable intake and lowered cancer deaths in an elderly population. Am J Clin Nutr 1985; 41: 32–6.
Long-de W, Hammond EC. Lung cancer, fruit, green salad and vitamin pills. Chin Med J 1985; 98: 206–10.
Phillips RL, Snowdon DA. Dietary relationships with fatal colorectal cancer among Seventh-Day Adventists. JNCI 1985; 74: 307–17.
Hirayama T. Relationship of soybean paste soup intake to gastric cancer risk. Nutr Cancer 1982; 3: 223–33.
Hirayama T. Does daily intake of green-yellow vegetables reduce the risk of cancer in man? An example of the application of epidemiologic methods to the identification of individuals at low risk. Lyon: International Agency for Research on Cancer, 1982; IARC Sci. Pub. No. 39: 531–40.
Hirayama T. Nutrition and cancer—a large scale cohort study. Prog Clin Biol Res 1986; 206: 299–311.
Mills PK, Beeson WL, Abbey DE, Fraser GE, Phillips RL. Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists. Cancer 1988; 61: 2578–85.
Mills PK, Beeson L, Phillips RL, Fraser GE. Bladder cancer in a low risk population: Results from the Adventist Health Study. Am J Epidemiol 1991; 133: 230–9.
Fraser GE, Beeson WL, Phillips RL. Diet and lung cancer in California Seventh Day Adventists. Am J Epidemiol 1991; 133: 683–93.
Steinmetz KA, Potter JD, Folsom AR. Unpublished data, 1991.
Stocks P, Karn MN. A co-operative study of the habits, home life, dietary and family histories of 450 cancer patients and of an equal number of control patients. Ann Eugenics 1933; 5: 30–280.
Stocks P. Cancer incidence in North Wales and Liverpool region in relation to habits and environment. In: British Empire Cancer Campaign 35th Annual Report Suppl. to Part II. London: BECC, 1957: 1–127.
MacLennan R, Da Costa J, Day NE, Law CH, Ng YK, Shanmugaratnam K. Risk factors for lung cancer in Singapore Chinese, a population with high female incidence rates. Int J Cancer 1977; 20: 854–60.
Mettlin C, Graham S, Swanson M. Vitamin A and cancer. JNCI 1979; 62: 1435–8.
Ziegler RG, Mason TJ, Stemhagen A, et al. Carotenoid intake, vegetables, and the risk of lung cancer among white men in New Jersey. Am J Epidemiol 1986; 123: 1080–93.
Pisani P, Berrino F, Macaluso M, Pastorino U, Crosignani P, Baldasseroni A. Carrots, green vegetables and lung cancer: a case-control study. Int J Epidemiol 1986; 15: 463–8.
Koo LC. Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked. Nutr Cancer 1988; 11: 155–72.
Fontham ETH, Pickle LW, Haenszel W, Correa P, Lin Y, Falk R. Dietary vitamin A and C and lung cancer risk in Louisiana. Cancer 1988; 62: 2267–73.
Le Marchand L, Yoshizawa CN, Kolonel LN, Hankin JH, Goodman MT. Vegetable consumption and lung cancer risk: a population-based case-control study in Hawaii. JNCI 1989; 81: 1158–64.
Mettlin C. Milk drinking, other beverage habits, and lung cancer risk. Int J Cancer 1989; 43: 608–12.
Graham S, Marshall J, Mettlin C, Rzepka T, Nemoto T, Byers T. Diet in the epidemiology of breast cancer. Am J Epidemiol 1982; 116: 68–75.
Zemla B. The role of selected dietary elements in breast cancer risk among native and migrant populations in Poland. Nutr Cancer 1984; 6: 187–95.
Katsuoyanni K, Trichopoulos D, Boyle P, et al. Diet and breast cancer: a case-control study in Greece. Int J Cancer 1986; 38: 815–20.
La Vecchia C, Decarli A, Franceschi S, Gentile A, Negri E, Parazzini F. Dietary factors and the risk of breast cancer. Nutr Cancer 1987; 10: 205–14.
Hislop TG, Kan L, Coldman AJ, Band PR, Brauer G. Influence of estrogen receptor status on dietary risk factors for breast cancer. Can Med Assoc J 1988; 138: 424–30.
Bjelke E. Case-control study in Norway. Scand J Gastroenterol 1974; 9 (Suppl. 31): 42–8.
Modan B, Barell V, Lubin F, Modan M, Greenberg RA, Graham S. Low-fiber intake as an etiologic factor in cancer of the colon. JNCI 1975; 55: 15–8.
Phillips RL. Role of life-style and dietary habits in risk of cancer among Seventh-Day Adventists. Cancer Res 1975; 35: 3513–22.
Graham S, Dayal H, Swanson M, Mittelman A, Wilkinson G. Diet in the epidemiology of cancer of the colon and rectum. JNCI 1978; 61: 709–14.
Miller AB, Howe GR, Jain M, Craib KJ, Harrison L. Food items and food groups as risk factors in a casecontrol study of diet and colo-rectal cancer. Int J Cancer 1983; 32: 155–61.
Tajima K, Tominaga S. Dietary habits and gastro-intestinal cancers: a comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan. Jpn J Cancer Res 1985; 76: 705–16.
Macquart-Moulin G, Riboli E, Cornee J, Charnay B, Berthezene P, Day N. Case-control study on colorectal cancer and diet in Marseilles. Int J Cancer 1986; 38: 183–91.
Kune S, Kune GA, Watson LF. Case-control study of dietary etiological factors: the Melbourne Colorectal Cancer Study, Nutr Cancer 1987; 9: 21–42.
Graham S, Marshall J, Haughey B, et al. Dietary epidemiology of cancer of the colon in western New York. Am J Epidemiol 1988; 128: 490–503.
La Vecchia C, Negri E, Decarli A, et al. A case-control study of diet and colo-rectal cancer in northern Italy. Int J Cancer 1988; 41: 492–8.
Slattery ML, Sorenson AW, Mahoney AW, French TK, Kritchevsky D, Street JC. Diet and colon cancer: assessment of risk by fiber type and food source. JNCI 1988; 80: 1474–80.
Tuyns AJ, Kaaks R, Haelterman M. Colorectal cancer and the consumption of foods: a case-control study in Belgium. Nutr Cancer 1988; 11: 189–204.
Young TB, Wolf DA. Case-control study of proximal and distal colon cancer and diet in Wisconsin. Int J Cancer 1988; 42: 167–75.
Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE. Colorectal cancer and diet in an Asian population-case-control study among Singapore Chinese. Int J Cancer 1989; 43: 1007–16.
Trock B, Lanza E, Greenwald P. Dietary fiber, vegetables, and colon cancer: critical review and metaanalyses of the epidemiologic evidence. JNCI 1990; 82: 650–61.
Haenszel W, Berg JW, Segi M, Kurihara M, Locke FB. Large-bowel cancer in Hawaiian Japanese. JNCI 1973; 51: 1765–79.
Bjelke E. Case-control study in Minnesota. Scand J Gastroenterol 1974; 9 (Suppl. 31): 49–53.
Martinez I, Torres R, Frias Z, Colon JR, Fernandez N. Factors associated with adenocarcinomas of the large bowel in Puerto Rico. In: Advances in Medical Oncology, Research, and Education, Vol. III. Oxford: Pergamon Press, 1979: 45–52.
Manousos O, Day NE, Trichopoulos D, Gerovassilis F, Tzonou A, Polychronopoulou A. Diet and colorectal cancer: a case-control study in Greece. Int J Cancer 1983; 32: 1–5.
Modan B, Cuckle H, Lubin F. A note on the role of dietary retinol and carotene in human gastrointestinal cancer. Int J Cancer 1981; 28: 421–4.
Hoff G, Moen IE, Trygg K, et al. Epidemiology of polyps in the rectum and sigmoid colon. Evaluation of nutritional factors. Scand J Gastroenterol 1986; 21: 199–204.
Macquart-Moulin G, Riboli E, Cornee J, Kaaks R, Berthezene P. Colorectal polyps and diet: a case-control study in Marseilles. Int J Cancer 1987; 40: 179–88.
Wynder EL, Bross IJ. A study of etiological factors in cancer of the esophagus. Cancer 1961; 14: 389–413.
De Jong UW, Breslow N, Goh Ewe Hong J, Sridharan M, Shanmugaratnam K. Aetiological factors in oesophageal cancer in Singapore Chinese. Int J Cancer 1974; 13: 291–303.
Cook-Mozaffari PJ, Azordegan F, Day NE, Ressicaud A, Sabai C, Aramesh B. Oesophageal cancer studies in the Caspian Littoral of Iran: results of a case-control study. Br J Cancer 1979; 39: 293–309.
Ziegler RG, Morris LE, Blot WJ, Pottern LM, Hoover R, Fraumeni JFJr. Esophageal cancer among black men in Washington DC. II. Role of nutrition. JNCI 1981; 67: 1199–206.
Mettlin C, Graham S, Priore R, Marshall J, Swanson M. Diet and cancer of the esophagus. Nutr Cancer 1981; 2: 143–7.
Decarli A, Liati P, Negri G, Franceschi S, La Vecchia C. Vitamin A and other dietary factors in the etiology of esophageal cancer. Nutr Cancer 1987; 10: 29–37.
Notani PN, Jayant K. Role of diet in upper aerodigestive tract cancers. Nutr Cancer 1987; 10: 103–13.
Tuyns AJ, Riboli E, Doombos G, Pequignot G. Diet and esophageal cancer in Calvados (France). Nutr Cancer 1987; 9: 81–92.
Yu MC, Garabrant DH, Peters JM, Mack TM. Tobacco, alcohol, diet, occupation, and carcinoma of the esophagus. Cancer Res 1988; 48: 3843–8.
Brown LM, Blot WJ, Shuman SH, et al. Environmental factors and high risk of esophageal cancer among men in coastal South Carolina. JNCI 1988; 80: 1620–5.
Li J, Ershow AG, Chen Z, et al. A case-control study of cancer of the esophagus and gastric cardia in Linxian. Int J Cancer 1989; 43: 755–61.
Chang-Claude JC, Wahrendorf J, Liang QS, et al. An epidemiological study of precursor lesions of esophageal cancer among young persons in a high-risk population in Huixian, China. Cancer Res 1990; 50: 2268–74.
Graham S, Mettlin C, Marshall J, Priore R, Rzepka T, Shedd D. Dietary factors in the epidemiology of cancer of the larynx. Am J Epidemiol 1981; 113: 675–80.
Zemla B. Day N, Swiatnicka J, Banasik R. Larynx cancer risk factors. Neoplasma 1987; 34: 223–33.
De Stefani, Correa P, Oreggia F, et al. Risk factors for laryngeal cancer. Cancer 1987; 60: 3087–91.
Graham S, Dayal H, Rohrer T. Dentition, diet, tobacco, and alcohol in the epidemiology of oral cancer. JNCI 1977; 59: 1611–8.
Jafarey NA, Mahmood Z, Zaidi SHM. Habits and dietary pattern of cases of carcinoma of the oral cavity and oropharynx. JPMA 1977; 27: 340–489.
Marshall J, Graham S, Mettlin C, Shedd D, Swanson M. Diet in the epidemiology of oral cancer. Nutr Cancer 1982; 3: 145–9.
Winn DM, Ziegler RG, Pickle LW, Gridley G, Blot WJ, Hoover RN. Diet in the etiology of oral and pharyngeal cancer among women from the southern United States. Cancer Res 1984; 44: 1216–22.
McLaughlin JK, Gridley G, Block G, et al. Dietary factors in oral and pharyngeal cancer. JNCI 1988; 80: 1237–43.
Franco EL, Kowalski LP, Oliveira BV, et al. Risk factors for oral cancer in Brazil. Int J Cancer 1989: 43: 992–1000.
La Vecchia C, Negri E, D'Avanzo B, Boyle P, Francerchi S. Dietary indicators of oral and pharyngeal cancer. Int J Epidemiol 1991; 20: 39–44.
Acheson ED, Doll R. Dietary factors in carcinoma of the stomach: a study of 100 cases and 200 controls. Gut 1964; 5: 126–31.
Graham S, Schotz W, Martino P. Alimentary factors in the epidemiology of gastric cancer. Cancer 1972; 30: 927–38.
Haenszel W, Kurihara M, Segi M, Lee RK. Stomach cancer among Japanese in Hawaii. JNCI 1972; 49: 969–88.
Modan B, Lubin F, Barell V, Greenberg RA, Modan M, Graham S. The role of starches in the etiology of gastric cancer. Cancer 1974; 34: 2087–92.
Haenszel W, Kurihara M, Locke FB, Shimuzu K, Segi M. Stomach cancer in Japan. JNCI 1976; 56: 265–74.
Correa P, Fontham E, Pickle LW, Chen V, Lin V, Haenszel W. Dietary determinants of gastric cancer in Louisiana inhabitants. JNCI 1985; 75: 645–54.
Risch HA, Jain M, Choi NW, et al. Dietary factors and the incidence of cancer of the stomach. Am J Epidemiol 1985; 122: 947–59.
Trichopoulos D, Ouranos G, Day NE, et al. Diet and cancer of the stomach: a case-control study in Greece. Int J Cancer 1985; 36: 291–7.
Jedrychowski W, Wahrendorf J, Popiel T, Rachtan J. A case-control study of dietary factors and stomach cancer risk in Poland. Int J Cancer 1986; 37: 837–42.
La Vecchia C, Negri E, Decarli A, D'Avanzo B, Franceschi S. A case-control study of diet and gastric cancer in northern Italy. Int J Cancer 1987; 40: 484–9.
Hu J, Zhang S, Jia E, et al. Diet and cancer of the stomach: a case-control study in China. Int J Cancer 1988; 41: 331–5.
You W, Blot WJ, Chang Y, et al. Diet and high risk of stomach cancer in Shandong, China. Cancer Res 1988; 48: 3518–23.
You WC, Blot WJ, Chang YS, et al. Allium vegetables and the reduced risk of stomach cancer. JNCI 1989; 81: 162–4.
Demirer T, Icli F, Uzunalimoglu O, Kucuk O. Diet and stomach cancer incidence. A case-control study in Turkey. Cancer 1990; 65: 2344–8.
Kato I, Tominaga S, Ito Y, et al. A comparative case-control analysis of stomach cancer and atrophic gastritis. Cancer Res 1990; 50: 6559–64.
Haenszel W, Correa P, Cuello C, et al. Gastric cancer in Colombia. II. Case-control epidemiologic study of precursor lesions. JNCI 1976; 57: 1021–6.
Gold EB, Gordis L, Diener MD, et al. Diet and other risk factors for cancer of the pancreas. Cancer 1985; 55: 460–7.
Mack TM, Yu MC, Hanisch R, Henderson BE. Pancreas cancer and smoking, beverage consumption, and past medical history. JNCI 1986; 76: 49–60.
Norell SE, Ahlbom A, Erwald R, et al. Diet and pancreatic cancer: a case-control study. Am J Epidemiol 1986; 124: 894–902.
Voirol M, Infante F, Raymond L, et al. Nutritional profile of patients with cancer of the pancreas. Schweiz Med Wochenschr 1987; 117: 1101–4.
Falk RT, Pickle LW, Fontham ET, Correa P, Fraumeni JFJr. Life-style risk factors for pancreatic cancer in Louisiana: a case-control study. Am J Epidemiol 1988; 128: 324–36.
Olsen GW, Mandel JS, Gibson RW, Wattenberg LW, Schuman LM. A case-control study of pancreatic cancer and cigarettes, alcohol, coffee, and diet. Am J Pub Health 1989; 79: 1016–19.
Farrow DC, David S. Diet and the risk of pancreatic cancer in men. Am J Epidemiol 1990; 132: 423–31.
Schuman LM, Mandel JS, Radke A, Seal U, Halberg F. Some selected features of the epidemiology of prostatic cancer: Minneapolis-St Paul, Minnesota case-control study, 1976–1979. In: Magnus K, ed. Trends in Cancer Incidence: Causes and Practical Implications. Washington DC: Hemisphere Publishing Corporation, 1982: 345–54.
Graham S, Haughey B, Marshall et al. Diet in the epidemiology of the prostate gland. JNCI 1983; 70: 687–92.
Talamini R, La Vecchia C, Decarli A, Negri E, Franceschi S. Nutrition, social factors and prostatic cancer in a Northern Italian population. Br J Cancer 1986; 53: 817–21.
Le Marchand L, Hankin JH, Kolonel LN, Wilkens LR. Vegetable and fruit consumption in relation to prostate cancer risk in Hawaii: a reevaluation of the effect of dietary beta-carotene. Am J Epidemiol 1991; 133: 215–9.
Mettlin C, Graham S. Dietary risk factors in human bladder cancer. Am J Epidemiol 1979; 110: 255–63.
La Vecchia C, Negri E, Decarli A, D'Avanzo B, Liberati C, Franceschi S. Dietary factors in the risk of bladder cancer. Nutr Cancer 1989; 12: 93–101.
Claude J, Kunze E, Frentzel-Beyme R, Paczkowski K, Schneider J, Schubert H. Life-style and occupational risk factors in cancer of the lower urinary tract. Am J Epidemiol 1986; 124: 578–89.
Byers T, Marshall J, Graham S, Mettlin C, Swanson M. A case-control study of dietary and nondietary factors in ovarian cancer. JNCI 1983; 71: 681–6.
La Vecchia C, Decarli A, Negri E, et al. Dietary factors and the risk of epithelial ovarian cancer. JNCI 1987; 79: 663–9.
La Vecchia C, Decarli A, Fasoli M, Gentile A. Nutrition and diet in the etiology of endometrial cancer. Cancer 1986; 57: 1246–53.
Zemla B, Guminski S, Banasik R. Studies of risk factors in invasive cancer of the corpus uteri. Neoplasma 1986; 33: 621–9.
La Vecchia C, Franceschi S, Decarli, et al. Dietary vitamin A and the risk of invasive cervical cancer. Int J Cancer 1984; 34: 319–22.
La Vecchia C, Decarli A, Fasoli M, et al. Dietary vitamin A and the risk of intraepithelial and invasive cervical neoplasia. Gynecol Oncol 1988; 30: 187–95.
Ziegler RG, Brinton LA, Hamman RF, et al. Diet and the risk of invasive cervical cancer among white women in the United States. Am J Epidemiol 1990; 132: 432–44.
Marshall JR, Graham S, Byers T, Swanson M, Brasure J. Diet and smoking in the epidemiology of cancer of the cervix. JNCI 1983; 70: 847–51.
Brock KE, Berry G, Mock PA, MacLennan R, Truswell AS, Brinton LA. Nutrients in diet and plasma and risk of in situ cervical cancer. JNCI 1988; 80: 580–5.
Ron E, Kleinerman RA, Boice JD, Li Volsi VA, Flannery JT, Fraumeni JFJr. A population based case-control study of thyroid cancer. JNCI 1987; 79: 1–12.
Franceschi S, Talamini R, Fassina A, Bidoli E. Diet and epithelial cancer of the thyroid gland. Tumori 1990; 76: 331–8.
Schiffman MH, Pickle LW, Fontham E, et al. Case-control study of diet and mesothelioma in Louisiana. Cancer Res 1988; 48: 2911–5.
Stryker WS, Stampfer MJ, Stein EA, et al. Diet, plasma levels of beta-carotene and alpha-tocopherol, and risk of malignant melanoma. Am J Epidemiol 1990; 131: 597–611.
Parazzini F, La Vecchia C, Mangili G, et al. Dietary factors and the risk of trophoblastic disease. Am J Obstet Gynecol 1988; 158: 93–9.
Pantuck EJ, Pantuck CB, Garland WA, et al. Stimulatory effect of Brussels sprouts and cabbage on human drug metabolism. Clin Pharmacol 1979; 25: 88–95.
Elmer P, Malone M, Potter J, Steinmetz K. Unpublished study, 1991.
Wattenberg LW. Studies of polycyclic hydrocarbon hydroxylases of the intestine possibly related to cancer. Effect of diet on benzpyrene hydroxylase activity. Cancer 1971; 28: 99–102.
Boyd JN, Sell S, Stoewsand GS. Inhibition of aflatoxin-induced serum alpha-fetoprotein in rats fed caullflower. Proc Soc Exp Biol Med 1979; 161: 473–5.
Troll W, Wiesner R, Shellabarger CJ, Holtzman S, Stone JP. Soybean diet lowers breast tumor incidence in irradiated rats. Carcinogenesis 1980; 1: 469–72.
Boyd JN, Babish JG, Stoewsand GS. Modification by beet and cabbage diets of aflatoxin B1-induced rat plasma alpha-foetoprotein elevation, hepatic tumorigenesis, and mutagenicity of urine. Food Chem Toxicol 1982; 20: 47–52.
Sparnins VL, Venegas PL, Wattenberg LW. Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dictary constituents. JNCI 1982; 68: 493–6.
Boyd JN, Misslbeck N, Stocwsand GS. Changes in preneoplastic response to aflatoxin B1 in rats fed green beans, beets or squash. Food Chem Toxicol 1983; 21: 37–40.
Rieder A, Adamek M, Wrba H. Delay of diethylnitrosamine-induced hepatoma in rats by carrot feeding. Oncology 1983; 40: 120–3.
Wattenberg LW. Inhibition of neoplasia by minor dietary constituents. Cancer Res 1983; 43 (Suppl.): 2448s-53s.
Ansher SS, Dolan P, Bueding E. Biochemical effects of dithiolthiones. Food Chem Toxicol 1986; 24: 405–15.
Stohs SJ, Lawson TA, Anderson L, Bueding E. Effects of oltipraz, BHA, ADT, and cabbage on glutathione metabolism, DNA damage and lipid peroxidation in old mice. Mech Ageing Development 1986; 37: 137–45.
Birt DF, Pelling JC, Pour PM, Tibbels MG, Schweickert L, Bresnick E. Enhanced pancreatic and skin tumorigenesis in cabbage-fed hamsters and mice. Carcinogenesis 1987; 8: 913–7.
Temple LJ, Basu TK. Selenium and cabbage and colon carcinogenesis in mice. JNCI 1987; 79: 1131–4.
Stoewsand GS, Anderson JL, Munson L. Protective effects of dietary Brussels sprouts against mammary carcinogenesis in Sprague-Dawley rats. Cancer Lett 1988; 39: 199–207.
Huang M, Ho C, Cheng S, et al. Inhibitory effect of an extract of leaves of rosmarinus officinalis L. on tumor promotion by 12-O-tetradecanoyl-phorbol-13-acetate on mouse skin. Proc Am Assoc Cancer Res 1989; 30: 180.
Scholar EM, Wolterman K, Birt DF, Bresnick E. The effect of diets enriched in collards on murine pulmonary metastasis. Nutr Cancer 1989; 12: 121–6.
Wattenberg LW, Schafer HW, Waters LJr., Davis DW. Inhibition of mammary tumor formation by broccoli and cabbage. Proc Am Assoc Cancer Res 1989; 30: 181.
Münzner R. Modifying action of vegetable juice on the mutagenicity of beef extract and nitrosated beef extract. Food Chem Toxicol 1986; 24: 847–9.
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Authors are with the Division of Epidemiology, School of Public Health, University of Minnesota, 1-210 Moos Tower, 515 Delaware Street SE, Minneapolis, MN 55455, USA. Address correspondence to Dr Potter. This work was supported by NIH Grants CA 50305, CA 46618, and CA 09607.
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Steinmetz, K.A., Potter, J.D. Vegetables, fruit, and cancer. I. Epidemiology. Cancer Causes Control 2, 325–357 (1991). https://doi.org/10.1007/BF00051672
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DOI: https://doi.org/10.1007/BF00051672