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Biological Reactive Intermediates IV pp 1–11Cite as

Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediates

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 283))

Abstract

Cytochrome P-450 (P-450) enzymes are involved in the oxidation of many steroids, eicosanoids, pesticides, drugs, and carcinogens. Considerable evidence has been accrued over the years to support the view that the majority of chemical carcinogens require bioactivation in order to elicit tumor initiation, and many toxic chemicals other than carcinogens also require bioactivation. The P-450 enzymes are probably involved to a greater extent than any other enzymes in the generation of the biological reactive intermediates involved in such toxicities (for reviews see Nelson, 1982; Guengerich and Liebler, 1985; Nelson and Harvison, 1987; Kadlubar and Hammons, 1987; Guengerich, 1988). Thus, a proper knowledge of these enzymes and the chemistry involved in catalysis is requisite for a rational understanding of schemes of toxicity and carcinogenesis.

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Authors and Affiliations

  1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    F. Peter Guengerich, Tsutomu Shimada & Arnaud Bondon

  2. Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232, USA

    F. Peter Guengerich, Tsutomu Shimada & Arnaud Bondon

  3. Department of Chemistry, University of Virginia, Charlottesville, Virginia, 22901, USA

    Timothy L. Macdonald

Authors
  1. F. Peter Guengerich
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  2. Tsutomu Shimada
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  3. Arnaud Bondon
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  4. Timothy L. Macdonald
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Editor information

Editors and Affiliations

  1. Rutgers University, Piscataway, New Jersey, USA

    Charlotte M. Witmer  & Robert R. Snyder  & 

  2. Medical University of South Carolina, Charleston, South Carolina, USA

    David J. Jollow

  3. Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    George F. Kalf  & James J. Kocsis  & 

  4. University of Arizona, Tucson, Arizona, USA

    I. Glenn Sipes

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© 1991 Plenum Press, New York

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Guengerich, F.P., Shimada, T., Bondon, A., Macdonald, T.L. (1991). Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediates. In: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J., Sipes, I.G. (eds) Biological Reactive Intermediates IV. Advances in Experimental Medicine and Biology, vol 283. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5877-0_1

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  • DOI: https://doi.org/10.1007/978-1-4684-5877-0_1

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