Regular ArticleMethylmercury Affects Multiple Subtypes of Calcium Channels in Rat Cerebellar Granule Cells☆
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Mechanisms of oxidative stress in methylmercury-induced neurodevelopmental toxicity
2021, NeuroToxicologyApplication of electrophysiological technique in toxicological study: From manual to automated patch-clamp recording
2020, TrAC - Trends in Analytical ChemistryCitation Excerpt :This mechanism not only decreases the effective calcium current but also contributes to the toxicity derived from intracellular metal ions [75]. Some of the organic derivatives of these cations, for example, methylmercury, target certain active sites in ion channels, probably causing irreversible inactivation [77]. Thus, due to the high need for direct detection of ion currents, patch-clamp is one of the most popular tools for such studies.
Post-translational modifications in MeHg-induced neurotoxicity
2019, Biochimica et Biophysica Acta - Molecular Basis of DiseaseOxidative stress, caspase-3 activation and cleavage of ROCK-1 play an essential role in MeHg-induced cell death in primary astroglial cells
2018, Food and Chemical ToxicologyCitation Excerpt :MeHg inhibits the astrocytic uptake of cystine and cysteine, compromising glutathione (GSH) synthesis and cellular redox status (Allen et al., 2001b; Shanker et al., 2001; Shanker and Aschner, 2003). In addition, MeHg exposure disrupts the functionality of neurotransmitter receptors (Castoldi et al., 1996; Eldefrawi et al., 1977; Rajanna et al., 1997) and calcium ion channels (Sirois and Atchison, 2000), inhibition of protein synthesis and microtubule assembly (Cheung and Verity, 1985; Miura et al., 1998), damaging to mitochondria and increasing oxidative stress (Farina et al., 2011a; Polunas et al., 2011). While the molecular steps leading to these cellular events have yet to be fully understood, the high affinity of mercurials for protein and nonprotein thiols (–SH) has long been suggested as a fundamental molecular interaction that results in MeHg's biological activity (Hughes, 1957) and the ensuing toxicity.
Toxicology of the Neuromuscular Junction
2018, Comprehensive Toxicology: Third Edition
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Preliminary results of parts of this paper were presented in abstract form at the 35th Annual Meeting of the Society of Toxicology and were published in abstract form in The Toxicologist,30(26), 1996. This paper was submitted by J.E.S. in partial fulfillment of the requirements for the Ph.D. degree in Pharmacology and Toxicology and Environmental Toxicology at Michigan State University.
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Present address: Department of Pharmacology, University of Virginia Health Sciences Center, Jordan Hall, HSC Box 448, Charlottesville, Virginia, 22908.