Regular ArticleActivation of Human Monocytes with Lipopolysaccharide Induces Metallothionein Expression and Is Diminished by Zinc
References (0)
Cited by (58)
Cross-talk between biometal ions and immune cells for bone repair
2024, Engineered RegenerationMetalloimmunology: The metal ion-controlled immunity
2020, Advances in ImmunologyCitation Excerpt :In dendritic cells, paradoxically, efflux rather than influx of the intracellular Zn2 + was detected during the LPS induced dendritic cell maturation. Activation of DCs led to reduced expression of the importer ZIP6/10 and upregulation of the exporters ZnT1/4/6 and MTs (Kitamura et al., 2006), thereby reducing the level of free intracellular Zn2 + (Leibbrandt & Koropatnick, 1994). The Zn2 + efflux is indispensably required for DCs maturation (Kitamura et al., 2006; Liu et al., 2013; Sayadi, Nguyen, Bard, & Bard-Chapeau, 2013), compared with the Zn2 + influx in macrophage activation.
Zinc Signals and Immune Function
2017, Molecular, Genetic, and Nutritional Aspects of Major and Trace MineralsZinc homeostasis and immunity
2007, Trends in ImmunologyCitation Excerpt :The amount of zinc bound to metallothionein is regulated not only by its quantity but also by its redox status [19]. Although it has not been investigated in DCs in this particular case [7], it is known that LPS induces metallothionein expression and, thereby, lowers the available zinc [21]. The effects described by Kitamura et al. are not caused by a single mechanism; zinc seems to function on at least two different levels.
Metallothionein gene expression in peripheral lymphocytes and renal dysfunction in a population environmentally exposed to cadmium
2005, Toxicology and Applied PharmacologyGene expression profiling of bovine macrophages in response to Escherichia coli O157:H7 lipopolysaccharide
2004, Developmental and Comparative Immunology