Regular ArticleFetal Thymic Atrophy after Exposure to T-2 Toxin: Selectivity for Lymphoid Progenitor Cells
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Diethylstilbestrol (DES) induces autophagy in thymocytes by regulating Beclin-1 expression through epigenetic modulation
2018, ToxicologyCitation Excerpt :In the thymus, several changes such as apoptosis in thymic cells, T cell differentiation, immunotoxicity, and immunosuppression have been reported post-DES exposure (Badewa et al., 2002; Brown et al., 2006a). Previous studies have demonstrated that DES caused a decrease in prothymocyte stem cells (Holladay et al., 1993), decrease in double positive CD4+CD8+ cells (Smith and Holladay, 1997; Brown et al., 2006a), as well as cell death in thymocyte subsets CD4+CD8+, CD4+CD8− and CD4−CD8+ (Calemine et al., 2002; Brown et al., 2006b). DES has also been shown to induce apoptosis in double- negative (CD4−CD8−) cells in fetal thymic organ culture system (Lai et al., 2000).
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