Regular ArticlePhenylpropanolamine Potentiation of Acetaminophen-Induced Hepatotoxicity: Evidence for a Glutathione-Dependent Mechanism
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Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase™
2015, Regulatory Toxicology and PharmacologyCitation Excerpt :As carbamazepine induces several cytochrome P450s, it could enhance hepatotoxicity through this mechanism. Other compounds, including sympathetic stimulants, deplete glutathione (James et al., 1993) and inhibit liver repair mechanisms (Oben et al., 2003) thus increasing susceptibility. Carboxamides, pyrazinamide, and isoniazid are also known to induce epigenetic modifications (i.e., hypo-methylation and/or histone acetylation); decreased histone acetylation with isoniazid administration impairs liver regeneration after injury (Poirier and Wise, 2003; Murata et al., 2007).
Lysosome vacuolation disrupts the completion of autophagy during norephedrine exposure in SH-SY5Y human neuroblastoma cells
2013, Brain ResearchCitation Excerpt :However, Nor is still available as a component of pharmaceutical products, dietary supplements and illegal drugs in many countries. Nor-induced cytotoxicity, which includes myocardial necrosis, hepatocytic necrosis, and injury to erythrocyte membranes, has been documented (Pentel et al., 1987; James et al., 1993; Suwalsky et al., 2011). However, despite the extensive information now available regarding Nor toxicity, detailed reports of the molecular mechanisms underlying this, particularly in neuronal cells, are scarce.
Co-medications That Modulate Liver Injury and Repair Influence Clinical Outcome of Acetaminophen-Associated Liver Injury
2009, Clinical Gastroenterology and HepatologyCitation Excerpt :Further studies are needed to determine whether HGF may effectively enhance liver regeneration in older subjects. Sympathetic stimulants are known to enhance liver injury in the APAP animal model, partially via depletion of glutathione.22 Also, they inhibit hepatic regeneration through the inhibition of oval cell proliferation via adrenoreceptors.16,25
Prooxidant activity and toxicity of nordihydroguaiaretic acid in clone-9 rat hepatocyte cultures
2006, Food and Chemical ToxicologyProtection against paracetamol-induced hepatic injury by prazosin pre-treatment in CD-1 mice
2005, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisHepatotoxicity of androstenedione in pregnant rats
2005, Food and Chemical ToxicologyCitation Excerpt :Differences between the treated and control parameters with p ⩽ 0.05 were considered statistically significant. Hepatic ALT, AST, LDH, GSH, GST, P450, lipid peroxidation and DNA damage are commonly used as biomarkers of hepatotoxicity (Griffin et al., 1996; Hasegawa et al., 1995; James et al., 1993; Parola et al., 1996; Shen et al., 1994; Ushakova et al., 1996; Videla et al., 1995). The ALT and AST activities in serum are commonly used as clinical liver function tests.